Screening and evaluation of antiparasitic and in vitro anticancer activities of Panamanian endophytic fungi.Many compounds produced by fungi have relevant pharmaceutical applications. The purpose of this study was to collect and isolate endophytic fungi from different regions of Panama and then to test their potential therapeutic activities against Leishmania donovani, Plasmodium falciparum, and Trypanosoma cruzi as well as their anticancer activities in MCF-7 cells. Of the 25 fungal isolates obtained, ten of them had good anti-parasitic potential, showing selective activity against L. donovani; four ...201122069153
antileishmanial constituents of the panamanian endophytic fungus edenia sp.bioassay-directed fractionation of extracts from the fermentation broth and mycelium of the fungus edenia sp. led tothe isolation of five antileishmanial compounds, preussomerin eg1 (1), palmarumycin cp2 (2), palmarumycin cp17 (3), palmarumycin cp18 (4), and cj-12,371 (5). compounds 3 and 4 are new natural products, and this is only the second report of compound 1. the structures of compounds 1-5 were established by spectroscopic analyses (hrms and nmr). all metabolites caused significant inhibi ...200819007286
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