| berkeleydione and berkeleytrione, new bioactive metabolites from an acid mine organism. | [structure: see text] two novel hybrid polyketide-terpenoid metabolites were isolated from a penicillium sp. growing in the berkeley pit lake of butte, montana. their structures were deduced by spectroscopic analysis and confirmed by single-crystal x-ray analysis on berkeleydione (1). both compounds inhibited matrix metalloproteinase-3 and caspase-1, and berkeleydione showed activity toward non-small-cell lung cancer in nci's human cell line antitumor screen. | 2004 | 15012097 |