| asian genotypes of jc virus in native americans and in a pacific island population: markers of viral evolution and human migration. | the human polyomavirus jc (jcv) causes the central nervous system demyelinating disease progressive multifocal leukoencephalopathy. previously, we showed that 40% of caucasians in the united states excrete jcv in the urine as detected by pcr. we have now studied 68 navaho from new mexico, 25 flathead from montana, and 29 chamorro from guam. by using pcr amplification of a fragment of the vp1 gene, jcv dna was detected in the urine of 45 (66%) navaho, 14 (56%) flathead, and 20 (69%) chamorro. gen ... | 1997 | 9405649 |
| human polyomavirus jc variants in papua new guinea and guam reflect ancient population settlement and viral evolution. | the peopling of the pacific was a complex sequence of events that is best reconstructed by reconciling insights from various disciplines. here we analyze the human polyomavirus jc (jcv) in highlanders of papua new guinea (png), in austronesian-speaking tolai people on the island of new britain, and in nearby non-austronesian-speaking baining people. we also characterize jcv from the chamorro of guam, a micronesian population. all jcv strains from png and guam fall within the broad asian group pr ... | 2000 | 10967279 |