Publications

legionnaires' disease caused by legionella pneumophila serogroup 3.		1979	89463
legionella pneumonia in the niagara region, ontario, canada: a case series.	legionella pneumophila, a major cause of legionnaires' disease, accounts for 2-15 % of all community-acquired pneumonia requiring hospitalization and up to 30 % of community-acquired pneumonia requiring intensive care unit admission. early initiation of appropriate antimicrobial therapy is a crucial step in the prevention of morbidity and mortality. however, recognition of legionnaires' disease continues to be challenging because of its nonspecific clinical features. we sought to describe hospit ...	2016	27906087
comparative genomics reveal that host-innate immune responses influence the clinical prevalence of legionella pneumophila serogroups.	legionella pneumophila is the primary etiologic agent of legionellosis, a potentially fatal respiratory illness. amongst the sixteen described l. pneumophila serogroups, a majority of the clinical infections diagnosed using standard methods are serogroup 1 (sg1). this high clinical prevalence of sg1 is hypothesized to be linked to environmental specific advantages and/or to increased virulence of strains belonging to sg1. the genetic determinants for this prevalence remain unknown primarily due ...	2013	23826259
new endemic legionella pneumophila serogroup i clones, ontario, canada.	the water-borne pathogen legionella pneumophila serogroup 1 (lp1) is the most commonly reported etiologic agent of legionellosis. to examine the genetic diversity, the long-term epidemiology, and the molecular evolution of lp1 clinical isolates, we conducted sequence-based typing on a collection of clinical isolates representing 3 decades of culture-confirmed legionellosis in ontario, canada. analysis showed that the population of lp1 in ontario is highly diverse and combines lineages identified ...	2010	20202420
molecular typing of a legionella pneumophila outbreak in ontario, canada.	an outbreak of legionnaires' disease at a long-term care facility in ontario, canada from september to october 2005 resulted in the death of 23 residents and the illness of 112 other people. in response, molecular methods were developed to detect legionella pneumophila in clinical lung samples and to subtype isolates from clinical and environmental samples. the targeted genetic loci included legionella-specific virulence determinants (mip, icmo, sida and lida) and core bacterial determinants (ft ...	2007	17314363
plumbing system shock absorbers as a source of legionella pneumophila.	water distribution systems have been demonstrated to be a major source of nosocomial legionellosis. we describe an outbreak in our institution in which a novel source of legionella pneumophila was identified in the plumbing system.	1992	1492694
laboratory-based evaluation of legionellosis epidemiology in ontario, canada, 1978 to 2006.	legionellosis is a common cause of severe community acquired pneumonia and respiratory disease outbreaks. the ontario public health laboratory (ophl) has conducted most testing for legionella species in the canadian province of ontario since 1978, and represents a multi-decade repository of population-based data on legionellosis epidemiology. we sought to provide a laboratory-based review of the epidemiology of legionellosis in ontario over the past 3 decades, with a focus on changing rates of d ...	2009	19460152
incidence of legionella organisms in selected ontario (canada) cities.	the distribution of legionella pneumophila in water inside buildings was examined by means of culture methods. cooling tower sumps and condenser valves harboured the organism at the highest frequency and in the highest concentrations. the bacterium was also frequently isolated from potable water systems, including hot and cold mixed taps, drinking water fountains and showers. when water quality parameters were examined, only elevated ph, total particulate nitrogen and alkalinity were correlated ...	1984	6523127