| development of rt-semi-nested pcr for detection of hepatitis a virus in stool in epidemic conditions. | the purpose of this study was to determine the efficiency of semi-nested pcr in detecting hepatitis a virus (hav) rna. during a 2-year period (1990-1991), hav rna was searched for in shellfish from the french brittany coasts using crna and vrna probes. in january 1992, at the time of a hepatitis a outbreak, 28 stool samples were collected from infected patients (18 adults, 10 children) with anti-hav igm. four samples from subjects with negative hav serology were used as negative controls. nuclei ... | 1994 | 7935509 |
| genetic analysis of hepatitis a virus outbreak in france confirms the co-circulation of subgenotypes ia, ib and reveals a new genetic lineage. | genetic analysis of selected genome regions of hepatitis a virus (hav) suggested that distinct genotype could be defined in different geographic locations. in order to study the degree of genetic variability among hav isolated during a single epidemic outbreak, sequences from a 148 base pair segment within the vp1 amino terminal region were obtained for eight distinct hav isolates from an outbreak that occurred in north bretagne (france). these sequences were compared among themselves and with p ... | 2001 | 11536228 |