| vegetation structure influences the burden of immature ixodes dammini on its main host, peromyscus leucopus. | to determine whether the relative abundance of immature ixodes dammini (the vector of lyme disease and human babesiosis) is related to habitat structure, we examined tick burdens on their main host, the white-footed mouse (peromyscus leucopus), in 4 structurally diverse sites on great island, massachusetts, usa. vegetation structure at each site was quantified with respect to 25 habitat variables. principal components analysis was used to reduce this set of habitat variables to seven new and ort ... | 1992 | 1437266 |
| mice as reservoirs of the lyme disease spirochete. | in evaluating the white-footed mouse as a reservoir host for the lyme disease spirochete, we compared spirochete infection in vector ticks (ixodes dammini) having different histories of attachment to these mice, estimated their relative importance as hosts for immature i. dammini and compared the seasonality of tick activity and spirochetemia in mice. infection in trapped white-footed mice appears to be universal. prevalence of spirochetal infection in i. dammini correlates with frequency of att ... | 1985 | 3985277 |
| fables for the instruction of youth published in boston in 1818. excerpt xii: lion and the mouse. | | 1973 | 4575725 |
| vectorial capacity of north american ixodes ticks. | ixodes dammini, the vector of lyme disease and babesiosis, is distributed in various locations in the northeastern quadrant of the united states and nearby canada. the life cycle of this tick, which includes larval, nymphal, and adult stages, spans at least two years. the tick over-winters between larval and nymphal feeding. horizontal transmission of pathogens is facilitated by a feeding pattern in which both the larval and nymphal stages feed on the white-footed mouse, peromyscus leucopus, and ... | 1984 | 6516453 |
| antibody response of the mouse reservoir of borrelia burgdorferi in nature. | to determine whether the white-footed mouse reservoir host (peromyscus leucopus) of the agent of lyme disease (borrelia burgdorferi) naturally mounts an immune response against the full range of antigens expressed by this zoonotic pathogen, we analyzed the pattern of immunoreactivity of these rodents at sites in which the intensity of transmission differs. although the incidence of seroconversion within the reservoir population relates proportionally to the density of subadult deer ticks (ixodes ... | 1995 | 7622226 |
| detection of borrelia burgdorferi dna in museum specimens of peromyscus leucopus. | to determine whether borrelia burgdorferi was enzootic within the united states at the beginning of the 20th century, ear skin samples taken from museum specimens of the white-footed mouse (peromyscus leucopus) were examined for evidence of spirochetal dna. in total, 280 samples from mice collected between 1870 and 1919 were analyzed by a nested polymerase chain reaction protocol. of these, 2 specimens from the vicinity of dennis, massachusetts, during 1894 were reproducibly positive for b. burg ... | 1994 | 7930700 |
| cosegregation of a novel bartonella species with borrelia burgdorferi and babesia microti in peromyscus leucopus. | during surveillance for various tickborne pathogens in the upper midwest during the summer and early fall of 1995, a bartonella-like agent was detected in the blood of mice that were concurrently infected with borrelia burgdorferi or babesia microti (or both). the organism was isolated in pure culture after inoculation of blood from wild-caught mice into c.b-17 scid/scid mice. phylogenetic analysis of the 16s rrna and the citrate synthase genes showed that the novel bartonella species and a bart ... | 1998 | 9466529 |
| helicobacter bilis/helicobacter rodentium co-infection associated with diarrhea in a colony of scid mice. | an outbreak of diarrhea spanning 3 months occurred in a breeding colony of scid/trp53 knockout mice. approximately a third of the 150 mice were clinically affected, with signs ranging from mucoid or watery diarrhea to severe hemorrhagic diarrhea with mortality. helicobacter bilis and the newly recognized urease-negative organism h. rodentium were isolated from microaerobic culture of feces or cecal specimens from affected mice. dual infection with h. bilis and h. rodentium were confirmed by cult ... | 1998 | 10090057 |
| physicians caught in the web. thanks to internet, doc disciplinary data now just a mouse click away. | the states are busy making more information available to the public about disciplinary actions taken against doctors. streamlining the process is the internet. most states now post data on web sites detailing actions taken against docs for unethical, questionable or criminal conduct. the next target for those seeking more information on their healthcare providers: the national practitioner data bank. one lawmaker promises legislation that would open it to the public. | 2000 | 11186522 |
| enzootic transmission of deer tick virus in new england and wisconsin sites. | to determine whether rodents that are intensely exposed to the deer tick-transmitted agents of lyme disease, human granulocytic ehrlichiosis, and human babesiosis are also exposed to deer tick virus (dtv), we assayed serum samples from white-footed mice (peromyscus leucopus) and meadow voles (microtus pennsylvanicus) in sites densely infested by deer ticks. to conduct serosurveys, we developed an enzyme-linked immunosorbent assay (elisa) and western blot assay by cloning, expressing, and purifyi ... | 2000 | 11357992 |
| association of the ala54-thr polymorphism in the intestinal fatty acid-binding protein with 2-h postchallenge insulin levels in the framingham offspring study. | to investigate the association of variants of the intestinal fatty acid-binding protein gene (fabp2) with fasting and postchallenge glucose and insulin levels, hba(1c), and prevalence of type 2 diabetes in a separate sample of men and women. | 2001 | 11423496 |
| multiplication of boston strains of coxsackievirus a9 in the adult mouse heart. | | 1965 | 14329472 |
| predictors of indoor exposure to mouse allergen in urban and suburban homes in boston. | mouse allergen exposure is prevalent among urban children with asthma. little is known about mouse allergen exposure in children at risk for the development of allergic diseases. | 2005 | 15813819 |
| determinants of allergen concentrations in apartments of asthmatic children living in public housing. | there is growing evidence linking poor housing conditions and respiratory diseases, including asthma. the association between housing conditions and asthma in the inner city has been attributed in part to cockroach and mouse infestation and the resulting allergen exposures. multiple social and behavioral factors can influence environmental exposures and health conditions, necessitating a thorough examination of such factors. as part of the healthy public housing initiative, we evaluated the asso ... | 2007 | 17216349 |
| observed finger behaviour during computer mouse use. | two-button computer mouse users may exhibit sustained, static finger lifting behaviours to prevent inadvertent activations by avoiding finger pressure on the buttons, which leads to prolonged, static finger extensor muscle loading. one hundred graduate students were observed during normal computer work in a university computer facility to qualify and quantify the prevalence of lifted finger behaviours and extended finger postures, as well as wrist/forearm and grip behaviour, during specific mous ... | 2008 | 17400173 |
| looking back. | in this perspective, i review my scientific career, which began after i trained in medicine in montreal and in neurology in boston. i started in immunology in london with avrion mitchison, using antibodies against cell-surface antigens to study the development and functions of mouse t and b cells. the finding that antibody binding causes immunoglobulin on b cells to redistribute rapidly on the cell surface and be endocytosed transformed me from an immunologist into a cell biologist. i moved with ... | 2011 | 21568709 |
| comparison of multiple environmental factors for asthmatic children in public housing. | nine families of a public housing development in boston were enrolled in a pilot asthma intervention program designed to gather dense environmental data and generate hypotheses about the relative importance of different contaminants and the viability of interventions. despite formidable challenges working with this inner-city population, the project team succeeded in gaining active support for the project by forming a partnership with a community-based organization and by building positive relat ... | 2003 | 12608922 |
| recent advances in the laboratory of molecular and cellular cardiology. | this article highlights some of the research in cardiac molecular biology in progress in the department of cardiology at children's hospital. it provides a sampling of investigative approaches to key questions in cardiovascular development and function and, as such, is intended as an overview rather than a comprehensive treatment of these problems. the featured projects, encompassing four different "model" systems, include (1) genetic analysis of the mef2 gene required for fruit fly cardial cell ... | 1995 | 8604921 |
| comparative virulence of blood and stool isolates of shigella sonnei. | shigellemia is rare in developed countries and might result from the emergence of unusually virulent strains. we compared systemic invasiveness markers of isolates from the blood of 3 temporally clustered patients with shigella sonnei bacteremia in boston with those of 11 unrelated contemporaneous strains from stools of people in new england. we found no difference between the two groups in o-chain length by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, mouse 50% lethal dose, in viv ... | 1994 | 8195402 |
| mhc determinants of response to rh immunization. | the demonstration of immune response genes in man has been difficult, although there is evidence for genes linked to the mhc in mouse and guinea pig that control both the specificity and magnitude of immune responses. a number of features of the antibody response to the rh d antigen, such as the failure of some individuals at risk to respond, the restricted immunoglobulin class, subclass, and light chain type of the antibody produced, and the presumed minor structural difference between rh d ant ... | 1984 | 6197442 |
| the mouse that roared: a case history of community organization for health practice. | this article presents a case study of a health education process, community organization, that deals with an issue of health protection. the issue concerns herbicide spraying along rights-of-way in leverett, massachusetts. the intervention team consisted of the author and a graduate class in community organization. the case study provides a description of the community and history of the problem, the nature of the intervention team, the theoretical and conceptual model held by the intervention t ... | 1985 | 4077547 |
| mutations in c-ki-ras oncogenes in diseased livers of winter flounder from boston harbor. | livers of a natural population of winter flounder from a contaminated site in boston harbor were examined for the presence of oncogenes by transfection of dna into nih 3t3 mouse fibroblasts. tissues analyzed contained histopathologic lesions including abnormal vacuolation, biliary proliferation, and, in many cases, hepatocellular and cholangiocellular carcinomas. fibroblasts transfected with liver dna samples from 7 of 13 diseased animals were effective in the induction of subcutaneous sarcomas ... | 1990 | 2405390 |
| reference intervals for plasma l-arginine and the l-arginine:asymmetric dimethylarginine ratio in the framingham offspring cohort. | l-arginine, as a precursor of no synthesis, has attracted much scientific attention in recent years. experimental mouse models suggest that l-arginine supplementation can retard, halt, or even reverse atherogenesis. in human studies, supplementation with l-arginine improved endothelium-dependent vasodilation. however, l-arginine levels are best interpreted in the context of levels of asymmetric dimethylarginine (adma), a competitive inhibitor of no synthase. thus, reference limits for circulatin ... | 2011 | 22031661 |
| relationships among environmental exposures, cord blood cytokine responses, allergy, and wheeze at 1 year of age in an inner-city birth cohort (urban environment and childhood asthma study). | the urban environment and childhood asthma study was established to investigate the immunologic and environmental causes of asthma in inner-city children. | 2011 | 21333343 |
| university students' notebook computer use: lessons learned using e-diaries to report musculoskeletal discomfort. | the objective of this pilot study was to identify if notebook accessories (ergonomic chair, desktop monitor and notebook riser) combined with a wireless keyboard, mouse and participatory ergonomics training would have the greatest impact on reducing self-reported upper extremity musculoskeletal discomfort in university students. in addition to pre-post computing and health surveys, the ecological momentary assessment was used to capture change in discomfort over time using a personal digital ass ... | 2011 | 21294018 |
| brief report: lymphocytic choriomeningitis virus transmitted through solid organ transplantation--massachusetts, 2008. | lymphocytic choriomeningitis virus (lcmv) is a rodent-borne arenavirus found worldwide. house mice (mus musculus) are the natural reservoir, but lcmv also can infect other wild, pet, and laboratory rodents (e.g., rats, mice, guinea pigs, and hamsters). humans can be infected through exposure to rodent excreta. person-to-person transmission has occurred only through maternal-fetal transmission and solid organ transplantation. lcmv infection in humans can be asymptomatic or cause a spectrum of ill ... | 2008 | 18650788 |
| forearm electromyographic changes with the use of a haptic force-feedback computer mouse. | to examine changes in biomechanical and motor control associated with a force-feedback computer mouse. | 2006 | 16696263 |
| effect of environmental intervention on mouse allergen levels in homes of inner-city boston children with asthma. | recent studies have suggested that mouse allergen exposure and sensitization are common in urban children with asthma. the effectiveness of environmental intervention in reducing mouse allergen exposure has not been established. | 2004 | 15104193 |