Publications

TitleAbstractYear
Filter
PMID
Filter
aeroallergens in dairy barns near cooperstown, new york and rochester, minnesota.we sampled atmospheric barn air using a volumetric air sampler in ten barns near cooperstown, ny and six barns near rochester, mn, and, with radioimmunoassays, measured allergens of aspergillus fumigatus, thermoactinomyces vulgaris, micropolyspori faeni, short ragweed, rye grass group i pollen, alternaria (alt-1), dermatophagoides sp. lepidoglyphus destructor, common insect allergen, mouse urine, rat urine, and cattle epithelium. the most abundant allergen present was a. fumigatus followed by l. ...19892764367
the prevalence and significance of borrelia burgdorferi in the urine of feral reservoir hosts.live borrelia burgdorferi were isolated from the blood and/or urine of white-footed mice (peromyscus leucopus) collected on shelter island, new york, in 1984 and 1985. prevalence of spirochetes in urine was consistently higher than in blood or both fluids simultaneously. spirochetes remained viable for 18-24 hours in urine and were maintained in culture for one week. mice removed from the field were spirocheturic for at least 13 months. one spirocheturic mouse developed spirochetemia one month a ...19863577491
an outbreak of botulism in waterfowl and fly larvae in new york state.in october 1982 the death of approximately 1,500 wild ducks, mostly mallards (anas platyrhynchos), and about 100 shore birds including greater yellowlegs (tringa melanoleuca) was observed in the new york state oak orchard wildlife management area. the lack of gross pathology, the signs exhibited by the moribund ducks, and the ecologic conditions indicated possible botulinal intoxication. clostridium botulinum toxin type c was demonstrated in duck serum (approximately 5 x 10(4) mouse intraperiton ...19846737616
analyses of mammalian sera in enzyme-linked immunosorbent assays with different strains of borrelia burgdorferi sensu lato.blood samples were collected from cottontail rabbits (sylvilagus floridanus), raccoons (procyon lotor), white-footed mice (peromyscus leucopus), and white-tailed deer (odocoileus virginianus) between 1977 and 1991 in southern connecticut and new york state (usa) and were tested for antibodies against eight strains of borrelia burgdorferi sensu lato in enzyme-linked immunosorbent assays. among these spirochetes were six strains of b. burgdorferi sensu stricto, one strain of b. garinii (=ip90) and ...19958583632
karyotype instability in cryptococcus neoformans infection.the electrophoretic karyotypes of 32 clinical and 3 environmental cryptococcus neoformans isolates from new york city were studied by contour clamped homogeneous electrophoresis. there was extensive variation among the electrophoretic karyotypes of isolates from different patients. sequential c. neoformans isolates from patients with chronic or relapsing infection had very similar karyotypes. however, minor differences in electrophoretic karyotypes were detected among sequential isolates from 50 ...19968735111
serologic evidence of infection with ehrlichia spp. in wild rodents (muridae: sigmodontinae) in the united states.rodent (muridae: sigmodontinae) blood and sera collected from 14 states were tested for seroreactivity to a cultured isolate of the human granulocytic ehrlichiosis (hge) agent by using an indirect immunofluorescence assay. of the 1,240 samples tested, 136 (11%) were found to be reactive at titers of > or = 32. rodents with hge agent-specific antibodies were found in new york (23% of 491 samples; geometric mean endpoint titer [gmt] = 441), connecticut (11% of 100 samples; gmt = 481), california ( ...19989508298
prenatal exposure, maternal sensitization, and sensitization in utero to indoor allergens in an inner-city cohort.primary sensitization to antigens may occur prenatally. we hypothesized that high prenatal exposure to indoor antigens increases the risk for sensitization in newborns in new york city populations with increased risk for asthma. we also investigated whether maternal sensitization is required for in utero sensitization to occur. one hundred sixty-seven pregnant african american or dominican women residing in northern manhattan were recruited and antigen was measured from home dust. after delivery ...200111587985
west nile virus infection in birds and mammals.west nile virus (wnv) was found throughout new york state in year 2000. the epicenter was located in new york city with a high level of activity in the immediately surrounding counties, including rockland, westchester, nassau, and suffolk. during 2000, wnv testing was performed by the wadsworth center on 3,687 dead birds, representing 153 species, 46 families, and 18 orders. there were 1,203 wnv-positive birds, representing 63 species, 30 families and 14 orders. the percentage of wnv-positive bi ...200111797807
the challenge of preventing environmentally related disease in young children: community-based research in new york city.rates of developmental and respiratory diseases are disproportionately high in underserved, minority populations such as those in new york city's washington heights, harlem, and the south bronx. blacks and latinos in these neighborhoods represent high risk groups for asthma, adverse birth outcomes, impaired development, and some types of cancer. the columbia center for children's environmental health in washington heights uses molecular epidemiologic methods to study the health effects of urban ...200211836150
effects of acorn production and mouse abundance on abundance and borrelia burgdorferi infection prevalence of nymphal ixodes scapularis ticks.risk of exposure to lyme disease is a function of the local abundance of nymphal ixodes ticks that are infected with the etiological agent, the spirochete borrelia burgdorferi. we monitored abundance of white-footed mice (the principal b. burgdorferi reservoir in the eastern and central united states) and acorns (a critical food resource for mice), and ixodes scapularis ticks, as well as ambient temperature (cumulative growing degree days) and growing season precipitation, in a forested landscap ...200112653136
spatiotemporal variation in a lyme disease host and vector: black-legged ticks on white-footed mice.we monitored population density of white-footed mice (peromyscus leucopus), burdens of immature black-legged ticks (ixodes scapularis) on mice, and infection prevalence of host-seeking ticks on six forest plots in southeastern new york state from 1995 through 1999. despite densities of mice that fluctuated two orders of magnitude, average larval and nymphal tick burdens per mouse remained remarkably constant. spatial variability in mouse density and tick burdens was modest. the total number of l ...200112653143
emergence of attenuated west nile virus variants in texas, 2003.in order to understand how west nile virus (wnv) has evolved since its introduction into north america, we have studied the genetic and phenotypic variation among wnv isolates collected in various areas during consecutive transmission seasons. the present report describes for the first time phenotypic changes occurring in the north american wnv population. several isolates collected in texas during 2003 display a small plaque (sp) and temperature sensitive (ts) phenotype, as well as reduced repl ...200415527859
saxitoxin puffer fish poisoning in the united states, with the first report of pyrodinium bahamense as the putative toxin source.from january 2002 to may 2004, 28 puffer fish poisoning (pfp) cases in florida, new jersey, virginia, and new york were linked to the indian river lagoon (irl) in florida. saxitoxins (stxs) of unknown source were first identified in fillet remnants from a new jersey pfp case in 2002.200617035133
determinants of cockroach and mouse exposure and associations with asthma in families and elderly individuals living in new york city public housing.asthma prevalence is high in the inner city, and morbidity has been associated with cockroach and mouse allergens.200617069106
two viruses isolated from rodents (clethrionomys gapperi and microtus pennsvlvanicus) trapped in st. lawrence county, new york.four strains of c. gapperi virus were isolated from 3 clethrionomys gapperi and 47 strains of microtus virus from 15 microtus pennsylvanicus and 1 mus musculus. one of the microtus strains was isolated from a pool of 20 mites while the others were from rodent tissues. these agehts were insensitive to ether and sodium desoxycholate, withstood freezing at -70 c for 3 years and lyophilization without loss of titer, and were not killed when heated at 60 c for 1 hour. their size as determined by filt ...197016509130
augmented production of panton-valentine leukocidin toxin in methicillin-resistant and methicillin-susceptible staphylococcus aureus is associated with worse outcome in a murine skin infection model.the role of panton-valentine leukocidin (pvl) in staphylococcus aureus infections is controversial. we used a mouse model of skin infection to compare the virulence of methicillin-resistant s. aureus (mrsa) and methicillin-susceptible s. aureus (mssa) strains with different levels of pvl production. differences in pvl production were not associated with mutations in the genes luks-pv and lukf-pv. however, mssa and mrsa strains that produced high levels of pvl caused larger skin abscesses, higher ...201019929693
polycyclic aromatic hydrocarbon metabolite levels and pediatric allergy and asthma in an inner-city cohort.exposure to polycyclic aromatic hydrocarbons (pah) has been associated with allergic sensitization and asthma. we hypothesized that increased urinary pah metabolites are associated with allergy or asthma among children age 5 yrs in an inner-city birth cohort. as part of an ongoing prospective birth cohort under the auspices of the columbia center for children's environmental health (ccceh), urine was collected from 5-yr-old children (n = 222) of dominican american and african american mothers in ...201020003063
molecular determinants of virulence of west nile virus in north america.west nile virus (wnv) is a mosquito-borne flavivirus that until very recently had not been found in the americas. in 1999, there was an outbreak of west nile encephalitis in new york and surrounding areas, involving 62 human cases, including 7 fatalities. the virus has subsequently become established in the united states of america (u.s.) with 4156 human cases, including 284 deaths, in 2002. the wnv strains found in the u.s. are members of "lineage i", a genetic grouping that includes viruses fr ...200415119761
distribution and determinants of mouse allergen exposure in low-income new york city apartments.previous studies of mouse allergens and laboratory-animal-worker-related allergy and asthma suggest that quantifying mouse allergen levels in homes could augment our understanding of inner-city asthma. we hypothesized that levels of mouse allergen in inner-city homes would be related to certain household characteristics. dust samples were collected from the kitchens and beds of 221 mothers enrolled in a prospective birth cohort study, 92 of african american and 129 of dominican ethnicity. sample ...200312896857
biodiversity of clostridium botulinum type e associated with a large outbreak of botulism in wildlife from lake erie and lake ontario.the genetic relatedness of clostridium botulinum type e isolates associated with an outbreak of wildlife botulism was studied using random amplification of polymorphic dna (rapd). specimens were collected from november 2000 to december 2008 during a large outbreak of botulism affecting birds and fish living in and around lake erie and lake ontario. in our present study, a total of 355 wildlife samples were tested for the presence of botulinum toxin and/or organisms. type e botulinum toxin was de ...201021115703
relationships among environmental exposures, cord blood cytokine responses, allergy, and wheeze at 1 year of age in an inner-city birth cohort (urban environment and childhood asthma study).the urban environment and childhood asthma study was established to investigate the immunologic and environmental causes of asthma in inner-city children.201121333343
cryptosporidium parvum infection involving novel genotypes in wildlife from lower new york state.cryptosporidium, an enteric parasite of humans and a wide range of other mammals, presents numerous challenges to the supply of safe drinking water. we performed a wildlife survey, focusing on white-tailed deer and small mammals, to assess whether they may serve as environmental sources of cryptosporidium. a pcr-based approach that permitted genetic characterization via sequence analysis was applied to wildlife fecal samples (n = 111) collected from september 1996 to july 1998 from three areas i ...200111229905
exposure to lymphocytic choriomeningitis virus, new york, usa.to the editor: lymphocytic choriomeningitis virus (lcmv) is an arenavirus carried by the house mouse, mus musculus. human infections can range from mild febrile illness to severe encephalitis and disseminated disease (1). infection during pregnancy is associated with teratogenic effects, including congenital hydrocephalus and chorioretinitis (2).201121762607
a polymorphic multigene family encoding an immunodominant protein from babesia microti.human babesiosis in the united states is caused predominantly by babesia microti, a tick-transmitted blood parasite. improved testing methods for the detection of infection with this parasite are needed, since asymptomatic b. microti infection represents a potential threat to the blood supply in areas where b. microti is endemic. we performed immunoscreening of an expression library of genomic dna from a human isolate of b. microti (strain mn1). among 17 unique immunoreactive clones, we identifi ...200010618117
ultrastructural and antigenic characterization of a granulocytic ehrlichiosis agent directly isolated and stably cultivated from a patient in new york state.a human granulocytic ehrlichiosis (hge) agent with 16s rdna sequence identical to the published sequence of hge agents was isolated from a patient from new york state by inoculation of the blood leukocyte fraction directly into a human promyelocytic leukemia cell line hl-60. the hge agent was also isolated from the leukocyte fraction of the blood and bone marrow of a mouse inoculated with the leukocyte fraction of the patient's blood. the isolate has been passaged in tissue culture 30 times over ...19978985223
agents of human anaplasmosis and lyme disease at camp ripley, minnesota.the transmission dynamics of anaplasma phagocytophilum (ap) and borrelia burgdorferi (bb) among ixodes scapularis (is) and mammalian hosts was investigated at camp ripley, an area representative of central minnesota. prevalence of white-footed mouse infection with ap and bb were 20% and 42%, respectively, with a coinfection level of 14%. peak levels of infection with both agents occurred in may. the average levels of seropositivity to ap and bb were 29.3% and 48%, respectively. of the mice infec ...201121867420
isolation of pathogenic hantavirus from white-footed mouse (peromyscus leucopus) 19947984010
molecular linkage of hantavirus pulmonary syndrome to the white-footed mouse, peromyscus leucopus: genetic characterization of the m genome of new york virus.the complete m segment sequences of hantaviruses amplified from tissues of a patient with hantavirus pulmonary syndrome in the northeastern united states and from white-footed mice, peromyscus leucopus, from new york were 99% identical and differed from those of four corners virus by 23%. the serum of this patient failed to recognize a conserved, immunodominant epitope of the four corners virus g1 glycoprotein. collectively, these findings indicate that p. leucopus harbors a genetically and anti ...19957494337
serologic analyses of peromyscus leucopus, a rodent reservoir for borrelia burgdorferi, in northeastern united states.an enzyme-linked immunosorbent assay (elisa) and indirect fluorescent-antibody test were used to detect antibodies to borrelia burgdorferi, the causative agent of lyme disease, in peromyscus leucopus (white-footed mouse). of the 661 mice captured in connecticut, rhode island, and new york during 1980 and 1983 to 1987, 166 (25.1%) had antibodies to b. burgdorferi by elisa. comparative analyses of 210 serum specimens, collected in areas where lyme disease is endemic, revealed a threefold differenc ...19883384925
habitat distribution of ixodes dammini (acari: ixodidae) an lyme disease spirochetes on fire island, new york.the distributions of ixodes dammini spielman, clifford, piesman, and corwin and lyme disease spirochetes were studied on fire island, n.y. adult ticks were more common in high-shrub habitats (shrubby vegetation greater than or equal to 1 m high) than in grassy and lowshrub habitats (vegetation less than 1 m) in spring and fall. in the fall, adults were also common in the woods. adults were more abundant on narrow trails than in nearby vegetation. during the summer, questing nymphs and larvae wer ...19892724316
chemical and biological investigations of a transformer accident at binghamton, ny.a transformer fire occurred in a state office building in binghamton, ny on february 5, 1981. particulates from inside surfaces of ceiling panels on 16 of the 17 floors had concentrations of polychlorinated dibenzofurans (pcdfs) ranging from less than 1 part per million (ppm) to 1200 ppm while polychlorinated biphenyl (pcb) concentrations varied from 28 ppm to 23,000 ppm. in spite of the wide variations in contaminant concentrations, complete analytical data from 11 floors showed that there was ...19852411536
microgeographic distribution of immature ixodes dammini ticks correlated with that of deer.in order to determine whether the small-scale distribution of immature ixodes dammini spielman et al. corresponds closely to the activity patterns of white-tailed deer, odocoileus virginianus (zimmerman), these relationships were examined in a site on long island, new york, u.s.a. we first determined the extent and temporal pattern of adult ticks feeding on deer by examining twenty-three resident deer tranquilized during september-december 1985. i. dammini adults infested deer throughout this fa ...19902132979
mouse genetics meets molecular biology at cold spring harbor. mouse molecular genetics sponsored by the cold spring harbor laboratory, cold spring harbor, ny, usa, august 29-september 2, 1990.as stated earlier, the digestion of roughly 100 short talks delivered within a few days and containing very condensed information is, even for experts, quite demanding. sometimes one felt in danger of becoming "psyched out" by all the experiments described; perhaps smaller group discussions dealing with experiments that have not worked, as well as the elimination of redundancies in the presentations, would have added to the flavor of the meeting. but what is the "take home message" from the 1990 ...19902088499
a comparison of methods for sampling the deer tick, ixodes dammini, in a lyme disease endemic area.the purpose of this study was to compare the trapping and examining of mice, drag sampling, and co2-baited traps for their ability to detect the presence and abundance of immature deer ticks, ixodes dammini, in a lyme disease endemic area in southern new york state. eight study sites were sampled 14 times between 28 may and 31 august by setting 49 live-traps, four co2-baited traps, and drag sampling 500 m2. a total of 1540 nymphs and 3079 larvae was collected during the study. drag sampling coll ...19921638929
salmonella in surface waters of central new york state.six tributary streams and southern cayuga lake in central new york state were sampled for the presence of salmonella on swabs immersed for 4 days. of a total of 322 swabs, 39% yielded salmonellae. swabs were cultured in tetrathionate enrichment at 41.5 degrees c. isolations were made from brilliant green agar. salmonellae were isolated from many sites on the streams and from some lake sites. twenty-five serotypes (11 somatic antigen groups) and a distinct biotype of s. typhimurium (h2s negative) ...1977326183
asthma, allergy, and ige levels in nyc head start children.among preschool-age children in new york city neighborhoods with high asthma hospitalization rates, we analyzed the associations of total immunoglobulin e (ige), specific ige to common indoor allergens, and allergy symptoms with asthma.201019913396
post 9/11: high asthma rates among children in chinatown, new york.we reported increased rates of childhood asthma and worsening of preexisting asthma in chinatown near the world trade center (wtc) after september 11, 2001. this conclusion was corroborated by the wtc health registry in 2003, which showed asthma prevalence in children <5 years old was higher than national estimates. in 2002, ethnic chinese in new york city (nyc), based on 2000 u.s. census addresses, were reported to have the lowest levels of asthma compared with other ethnic nyc neighborhoods. t ...200919772715
effectiveness of an integrated pest management intervention in controlling cockroaches, mice, and allergens in new york city public housing.cockroaches and mice, which are common in urban homes, are sources of allergens capable of triggering asthma symptoms. traditional pest control involves the use of scheduled applications of pesticides by professionals as well as pesticide use by residents. in contrast, integrated pest management (ipm) involves sanitation, building maintenance, and limited use of least toxic pesticides.200919672400
mite sensitization among latina women in new york, where dust-mite allergen levels are typically low.in new york (ny), latinos often have greater asthma morbidity than other ethnicities, and dust-mite sensitization is common despite low allergen levels. we investigated mite allergen exposure and sensitization in atopic and/or asthmatic women, the majority being puerto rican. women (n = 274) recruited for a birth cohort study were visited postnatally. dust from their homes was analyzed for mite allergens (der f 1, der p 1, and blo t 5). serum was analyzed for total and allergen-specific ige. thi ...200919220508
residual oil combustion: a major source of airborne nickel in new york city.on the basis of previous observations that: (1) both the nickel (ni) concentration in ambient air fine particulate matter (pm(2.5)) and daily mortality rates in new york city (nyc) were much higher than in any other us city; and (2) that peaks in ni concentration was strongly associated with cardiac function in a mouse model of atherosclerosis, we initiated a study of the spatial and seasonal distributions of ni in nyc and vicinity to determine the feasibility of productive human population-base ...200918841166
total and specific ige associations between new york city head start children and their parents.allergy and asthma risk share strong inherited components; however, the relative importance of maternal and paternal atopy in predicting child atopy remain unclear.200818472147
birth order, atopy, and symptoms of allergy and asthma among inner-city children attending head start in new york city.in past research, children with older siblings were more likely than others to wheeze at age 2 years, but less likely by age 6 years. higher infection transmission and a down-regulated allergic immune response as a result of these infections, respectively, were suggested as the causes. however, in a study of children aged 0-3 years in a low-income urban community in new york city, usa, with high asthma prevalence, we observed no birth-order effect.200818355370
genomic differences of vaccinia virus clones from dryvax smallpox vaccine: the dryvax-like acam2000 and the mouse neurovirulent clone-3.conventional vaccines used for smallpox eradication were often denoted one or another strain of vaccinia virus (vacv), even though seed virus was sub-cultured multifariously, which rendered the virion population genetically heterogeneous. acam2000 cell culture vaccine, recently licensed in the u.s., consists of a biologically vaccine-like vacv homogeneous-sequence clone from the conventional smallpox vaccine dryvax, which we verified from dryvax sequence chromatograms is genetically heterogeneou ...200718037545
the new transgenic mouse core: no longer a facility just for making mice.the times they are a-changin' for gem and the facilities that maintain them. core facilities are expanding beyond their original conception as producers of transgenic mice to encompass a wide range of services, including research animal maintenance. in this paper, the authors describe the logistics and administration of the newly dubbed mouse genetics core facility at the memorial sloan-kettering cancer center as a blueprint for other institutions seeking to expand and update their own transgeni ...200617077832
validating high-throughput micronucleus analysis of peripheral reticulocytes for radiation biodosimetry: benchmark against dicentric and cbmn assays in a mouse model.automation of radiation biodosimetry is one of the top priority tasks considered by the office of science and technology policy and the homeland security council in preparation for the nation's readiness for a possible radionuclear terrorist attack. the center for biophysical assessment and risk management following irradiation, a consortium of researchers and institutions centered at the university of rochester, has been investigating automated scoring of radiation-induced micronucleus formatio ...201020065686
are neighborhood-level characteristics associated with indoor allergens in the household?individual home characteristics have been associated with indoor allergen exposure; however, the influence of neighborhood-level characteristics has not been well studied. we defined neighborhoods as community districts determined by the new york city department of city planning. objective: we examined the relationship between neighborhood-level characteristics and the presence of dust mite (der f 1), cat (fel d 1), cockroach (bla g 2), and mouse (mup) allergens in the household.201020100024
neighborhood differences in exposure and sensitization to cockroach, mouse, dust mite, cat, and dog allergens in new york city.background: asthma prevalence varies widely among neighborhoods within new york city. exposure to mouse and cockroach allergens has been suggested as a cause. objective: to test the hypotheses that children living in high asthma prevalence neighborhoods (hapns) would have higher concentrations of cockroach and mouse allergens in their homes than children in low asthma prevalence neighborhoods (lapns), and that these exposures would be related to sensitization and asthma. methods: in the new york ...201121536321
web presence of an integrated delivery system at year one: lessons learned.the log analysis of a web site can be used to guide performance improvement. log analysis identifies which resources on a website are often accessed and those that are not. a log analysis can provide cost justification for a corporate web presence. we describe the log analysis of a large integrated delivery system in new york city from its launch may 1, 2001, through april 30, 2002. during this first year there were 428753 sessions with 1322153 page views. an analysis of page views, exclusive of ...200312706178
Childhood asthma and indoor allergen exposure and sensitization in Buffalo, New York.This nested case-control study examined the association between prevalent asthma and indoor allergen sensitization and/or exposure among children (aged 5-17 years) in Buffalo, New York. The study included a self-administered questionnaire, clinical interviews, skin allergen sensitivity tests and home dust sampling for house dust mites, cat, dog, cockroach and mouse allergens. After adjusting for multiple confounders, asthma cases had higher odds of being sensitized to Der p dust mites (odds rati ...201121962526
attenuated nycbh vaccinia virus deleted for the e3l gene confers partial protection against lethal monkeypox virus disease in cynomolgus macaques.the new york city board of health (nycbh) vaccinia virus is the currently licensed vaccine for use in the us against smallpox. the vaccine under investigation in this study has been attenuated by deletion of the innate immune evasion gene, e3l, and shown to be protective in homologous virus mouse challenge and heterologous virus mouse and rabbit challenge models. in this study we compared nycbh deleted for the e3l gene (nycbhδe3l) to nycbh for the ability to induce phosphorylation of proinflamma ...201122001879
infectious disease survey of mus musculus from pet stores in new york city.most mice used in research are purchased devoid of specific pathogens. experimental studies required us to evaluate the profile of infective agents harbored in mice sold as pets or food for captive reptiles. anecdotal reports regarding disease in these mice abound, but there are few published reports on disease prevalence. purchasers are unaware of the potential zoonotic or adventitious infections carried by these mice. this survey investigated the prevalence of ectoparasites, endoparasites, and ...201222330866
Displaying items 1 - 51 of 51