| molecular basis of a unique african variant (a-iv 5) of human apolipoprotein a-iv and its significance in lipid metabolism. | human apolipoprotein a-iv (apoa-iv) exhibits a genetically determined structural polymorphism amenable to analysis by isoelectric focusing and immunoblotting techniques. we have determined the allele frequency and molecular basis of a unique apoa-iv*5 allele which is widely distributed among blacks but is absent in other populations. the frequency of the apoa-iv*5 allele in blacks (n = 308) was estimated to be 3.2%. in comparison to the common apoa-iv*1 allele, analysis of coding and non-coding ... | 1992 | 1487136 |
| toxicity of adductor muscles from the purple hinge rock scallop (crassadoma gigantea) along the pacific coast of north america. | mouse bioassay results of rock scallops occasionally monitored by official agencies of british columbia, washington and california before and/or after algal blooms from 1980-1990 revealed that 24%, 38% and 87% of adductor muscles, whole body and viscera, respectively, were unsafe (greater than or equal to 80 micrograms saxitoxin equivalents/100 g tissue) for human consumption. the safety of adductor muscles could not be predicted from corresponding toxicity levels of the viscera but the absence ... | 1991 | 1926187 |
| isolation, enumeration, and characterization of aeromonas from polluted waters encountered in diving operations. | counts of total viable, aerobic, heterotrophic bacteria, indicator organisms, and aeromonas spp. were made at a diver training site on the anacostia river in washington, d.c. the numbers of aeromonas cells in anacostia river sediment and water increased during periods of elevated water temperature, to maxima of 4 x 10(5) cells per g of sediment and 300 cells per ml of water. correspondingly, aeromonas counts dropped 2 to 4 logs as the water temperature decreased to 0 to 0.5 degrees c. cultures t ... | 1980 | 7396482 |
| naturally occurring periodontal bone loss in the wild deer mouse, genus peromyscus. | historically, animal models for the study of periodontal diseases have incorporated surgically created defects, plaque retentive ligatures, as well as soft and high-sucrose diets which may not accurately reflect progression of the natural disease. spontaneous periodontal disease is seen in a few animal species, but these are often expensive to maintain and are unsuitable for manipulation using advanced molecular biology techniques. mice are inexpensive, easy to maintain, and are routinely used f ... | 2001 | 11394397 |
| genetic heterogeneity of borrelia burgdorferi sensu lato in the southern united states based on restriction fragment length polymorphism and sequence analysis. | fifty-six strains of borrelia burgdorferi sensu lato, isolated from ticks and vertebrate animals in missouri, south carolina, georgia, florida, and texas, were identified and characterized by pcr-restriction fragment length polymorphism (rflp) analysis of rrf (5s)-rrl (23s) intergenic spacer amplicons. a total of 241 to 258 bp of intergenic spacers between tandemly duplicated rrf (5s) and rrl (23s) was amplified by pcr. msei and drai restriction fragment polymorphisms were used to analyze these ... | 2001 | 11427560 |
| the challenge of preventing environmentally related disease in young children: community-based research in new york city. | rates of developmental and respiratory diseases are disproportionately high in underserved, minority populations such as those in new york city's washington heights, harlem, and the south bronx. blacks and latinos in these neighborhoods represent high risk groups for asthma, adverse birth outcomes, impaired development, and some types of cancer. the columbia center for children's environmental health in washington heights uses molecular epidemiologic methods to study the health effects of urban ... | 2002 | 11836150 |
| biologic and molecular characteristics of toxoplasma gondii isolates from striped skunk (mephitis mephitis), canada goose (branta canadensis), black-winged lory (eos cyanogenia), and cats (felis catus). | toxoplasma gondii isolates can be grouped into 3 genetic lineages. type i isolates are considered virulent to outbred mice, whereas type ii and iii isolates are not. in the present report, viable t. gondii was isolated for the first time from striped skunk (mephitis mephitis), canada goose (branta canadensis), and black-winged lory (eos cyanogenia). for the isolation of t. gondii, tissues were bioassayed in mice, and genotyping was based on the sag2 locus. toxoplasma gondii was isolated from 3 o ... | 2004 | 15562622 |
| the fleas (siphonaptera) of south carolina with an assessment of their vectorial importance. | we document 25 species of fleas from south carolina including new state records for two species, the ctenophthalmids epitedia cavernicola and rhadinopsylla orama. host and other collection data, by county, are provided, including many new records amassed from 1992-1998 and some older records gleaned from the clemson university arthropod collection. one flea species, the rhopalopsyllid polygenis gwyni, is especially common and widespread in south carolina, particularly on the cotton rat (sigmodon ... | 1999 | 10672546 |
| isolation, cultivation, and characterization of borrelia burgdorferi from rodents and ticks in the charleston area of south carolina. | twenty-eight borrelia burgdorferi isolates from the charleston, s.c., area are described. this represents the first report and characterization of the lyme disease spirochete from that state. the isolates were obtained from december 1994 through december 1995 from the tick ixodes scapularis, collected from vegetation, and from the rodents peromyscus gossypinus (cotton mouse), neotoma floridana (eastern wood rat), and sigmodon hispidus (cotton rat). all isolates were screened immunologically by i ... | 2000 | 10618074 |
| naturally acquired rabies in an eastern wood rat (neotoma floridana). | rabies in an eastern wood rat was detected by fluorescent antibody testing and mouse inoculation. the results were independently confirmed. | 1981 | 7007427 |
| transcriptional regulation of cardiac conduction system development: 2004 faseb cardiac conduction system minimeeting, washington, dc. | the development of the complex network of specialized cells that form the atrioventricular conduction system (avcs) during cardiac morphogenesis occurs by progressive recruitment within a multipotent cardiomyogenic lineage. understanding the molecular control of this developmental process has been the focus of recent research. transcription factors representative of multiple subfamilies have been identified and include members of zinc-finger subfamilies (gata4, gata6 hf-1b), skeletal muscle tran ... | 2004 | 15368344 |
| the prevalence and mouse virulence of cryptococcus neoformans strains isolated from urban areas. | | 1963 | 14063725 |
| particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice. | exposure to particulate matter (pm) air pollution may be an important environmental factor leading to exacerbations of inflammatory illnesses in the gi tract. pm can gain access to the gastrointestinal (gi) tract via swallowing of air or secretions from the upper airways or mucociliary clearance of inhaled particles. | 2011 | 21658250 |
| polycyclic aromatic hydrocarbon metabolite levels and pediatric allergy and asthma in an inner-city cohort. | exposure to polycyclic aromatic hydrocarbons (pah) has been associated with allergic sensitization and asthma. we hypothesized that increased urinary pah metabolites are associated with allergy or asthma among children age 5 yrs in an inner-city birth cohort. as part of an ongoing prospective birth cohort under the auspices of the columbia center for children's environmental health (ccceh), urine was collected from 5-yr-old children (n = 222) of dominican american and african american mothers in ... | 2010 | 20003063 |
| concentration ratios for small mammals collected from the exposed sediments of a 137cs contaminated reservoir. | (137)cs concentration ratios were computed for small mammals collected from the dried sediments of a partially drained, contaminated reservoir. soil (137)cs activity concentrations were heterogeneous on small and large spatial scales and had a geometric mean of 253 (range 23-2110) bq/kg dry weight. mean (137)cs activity concentrations in composite cotton rat sigmodon hispidus and cotton mouse peromyscus gossypinus samples averaged 2480 (range 556-6670) and 471 (range 96-1000) bq/kg whole body dr ... | 2006 | 16963166 |
| serum igm levels against select marine bacteria in the atlantic sharpnose shark (rhizoprionodon terraenovae) from three estuaries. | the atlantic sharpnose shark (rhizoprionodon terraenovae) is abundant and easily captured throughout the southeastern united states. therefore this species serves as an ideal model for generating basic immunological reagents to establish baseline information regarding the immunophysiology of sharks in the wild, and for attempting to correlate shark immune responses to potential pathogens with the quality of the habitat in which they reside. sharpnose shark serum igm was purified over a protein-a ... | 2006 | 16750427 |