| on the occurrence of microsporum persicolor in montreal, canada. | a case of microsporum persicolor skin infection in a casual employee of a veterinary clinic in montreal, quebec, canada, is reported. a survey of 80 wild rodents in the montreal area resulted in the isolation of m. persicolor from two voles (clethrionomys gapperi) and one deer mouse (peromyscus maniculatus). one of the voles, heavily infested with parasites including ticks, had obvious lesions on the nose. this is the first report of m. persicolor in rodents in north america. | 1978 | 714147 |
| coronaviruses associated with outbreaks of transmissible enteritis of turkeys in quebec: hemagglutination properties and cell cultivation. | coronaviruses were observed by electron microscopy in the intestinal contents of turkeys in quebec flocks where repeated outbreaks of enteritis occurred. three isolates could be serially propagated in turkey embryos inoculated by the amniotic route with clarified intestinal contents. purification and concentration of viral particles contained in intestinal contents of infected embryos were achieved by precipitation with polyethylene glycol and ultracentrifugation on sucrose density gradients. th ... | 1986 | 3015116 |
| the k-cl cotransporter kcc3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum. | peripheral neuropathy associated with agenesis of the corpus callosum (accpn) is a severe sensorimotor neuropathy associated with mental retardation, dysmorphic features and complete or partial agenesis of the corpus callosum. accpn is transmitted in an autosomal recessive fashion and is found at a high frequency in the province of quebec, canada. accpn has been previously mapped to chromosome 15q. the gene slc12a6 (solute carrier family 12, member 6), which encodes the k+-cl- transporter kcc3 a ... | 2002 | 12368912 |
| adrenomyeloneuropathy: report of a new mutation in a french canadian female. | x-linked adrenoleukodystrophy is a peroxisomial disorder caused by mutations in the abcd1 gene. adrenomyeloneuropathy is the second most frequent phenotype (25-46%) of this disease and classically presents in adulthood with spastic paraparesis. female heterozygotes can be symptomatic, but they are frequently misdiagnosed as having multiple sclerosis. | 2005 | 16018167 |
| [validation of a measurement instrument to evaluate computer access in people with physical disabilities]. | the aim of this study was to develop an instrument to measure performance in computer tasks for persons with physical impairments. the objectives were to assure the content validity and the internal consistency of the test as well as the reliability of each task. the first step was to determine the mouse and keyboard actions necessary to use a computer. resulting from these actions, 15 standardized computer tasks were designed as part of the test. to measure reliability and internal consistency, ... | 2000 | 10914480 |
| arsacs, a spastic ataxia common in northeastern québec, is caused by mutations in a new gene encoding an 11.5-kb orf. | autosomal recessive spastic ataxia of charlevoix-saguenay (arsacs or sacs) is an early onset neurodegenerative disease with high prevalence (carrier frequency 1/22) in the charlevoix-saguenay-lac-saint-jean (cslsj) region of quebec. we previously mapped the gene responsible for arsacs to chromosome 13q11 and identified two ancestral haplotypes. here we report the cloning of this gene, sacs, which encodes the protein sacsin. the orf of sacs is 11,487 bp and is encoded by a single gigantic exon sp ... | 2000 | 10655055 |
| linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the québec family study. | the agouti yellow mouse shows adult onset of moderate obesity and diabetes. a depressed basal lipolytic rate in adipocytes or a decreased adrenergic tone arising from antagonizing alpha-melanocyte-stimulating hormone (msh) activation of melanocortin receptors (mcr) could be at the origin of the obesity phenotype. | 1997 | 9392003 |
| genetic linkage studies in familial frontal epilepsy: exclusion of the human chromosome regions homologous to the el-1 mouse locus. | familial frontal epilepsy has been recently described in six pedigrees. all families reported show autosomal dominant inheritance with incomplete penetrance. affected individuals develop predominantly nocturnal seizures with frontal lobe semiology. in 1959, a genetic mouse model for partial epilepsy, the el mouse, was reported. in the el mouse, a major seizure susceptibility gene, el-1, segregates in an autosomal dominant fashion and has been localized to a region distal to the centromere of mou ... | 1995 | 8991790 |
| learning medical and dental sciences through interactive multi-media. | health professionals in various fields of medicine and dentistry must acquire comprehensive technological knowledge in order to practice their professions. a large portion of that knowledge cannot be found in a textbook. examples of this type of information are data gleaned from viewing microscopic slides and dissecting cadavers. in order to fully comprehend an area of study in medicine, the student relies on various resources (often physically unrelated, like the x-ray department and the dissec ... | 1995 | 8591560 |
| an exploratory investigation of genetic linkage with body composition and fatness phenotypes: the québec family study. | in the present investigation, we have attempted to identify regions of the genome in which "obesity genes" potentially reside using robust sib-pair linkage analysis. data were collected on 1,628 individuals in 301 nuclear families residing in the environs of québec city during the period 1978-1981. in addition to traditional blood group antigens and enzyme polymorphisms, several phenotypes in the obesity domain that are associated with increased morbidity were assessed, including measures relati ... | 1994 | 16355479 |
| characterization of a common susceptibility locus for asthma-related traits. | susceptibility to asthma depends on variation at an unknown number of genetic loci. to identify susceptibility genes on chromosome 7p, we adopted a hierarchical genotyping design, leading to the identification of a 133-kilobase risk-conferring segment containing two genes. one of these coded for an orphan g protein-coupled receptor named gpra (g protein-coupled receptor for asthma susceptibility), which showed distinct distribution of protein isoforms between bronchial biopsies from healthy and ... | 2004 | 15073379 |
| particle size fractionation of paralytic shellfish toxins (psts): seasonal distribution and bacterial production in the st lawrence estuary, canada. | we determined the seasonal distribution of paralytic shellfish toxins (psts) and pst producing bacteria in > 15, 5-15, and 0.22-5 microm size fractions in the st lawrence. we also measured psts in a local population of mytilus edulis. pst concentrations were determined in each size fraction and in laboratory incubations of sub-samples by high performance liquid chromatography (hplc), including the rigorous elimination of suspected toxin 'imposter' peaks. mussel toxin levels were determined by mo ... | 2002 | 12368115 |
| suggestive linkages between markers on human 1p32-p22 and body fat and insulin levels in the quebec family study. | a single-gene rodent mutation (diabetes) and a quantitative trait locus (dietary obese 1) mapped to the mid portion of mouse chromosome 4 have been related to obesity and/or insulin levels. synteny relationships place their putative human homologs on 1p31 and 1p35-p31, respectively. in 137 sibships of adult brothers and sisters from the québec family study, genetic linkages between seven microsatellite markers from 1p32-p22 and various obesity- and diabetes-related quantitative phenotypes were e ... | 1997 | 9112246 |