| [genetic origin of non-syndromic cleft lip and palate. twist, a candidate gene? research protocol]. | non syndromic cleft lip and palate (clp) is the most frequent human malformation. clp is of complex inheritance and at least twenty contributing chromosomal regions have been identified by linkage studies. on the other hand, mutations in several genes such as twist and fgfr2 result in syndromic cranio-facial abnormalities of highly variable range. it is our hypothesis that some mutations at twist might contribute to clp in absence of other dysmorphic features. thus, dna biopsies of patients with ... | 2007 | 18082115 |
| chromosomal and allozyme analysis of a hybrid zone between parapatric robertsonian races of the house mouse: a case of monobrachial homology. | a detailed chromosomal and allozyme analysis of robertsonian (rb) populations of the house mouse in alsace (france) was performed to evaluate the model of speciation by monobrachial centric fusions. the karyological analysis confirmed the existence of a hybrid zone between two rb races differentiated by monobrachially homologous rb fusions. the clinical distribution of rb fusions showed that almost no overlap occurred between the rb fusions specific to each race, indicating the presence of an ac ... | 2002 | 12438783 |
| [current trends in hemoglobin genetic diseases]. | the current aspects of genetic diseases of hemoglobin are as follows. (1) the localisation and the dimension of at-risk populations for sickle cell disease and thalassemia in metropolitan france are not exactly known. however, some recent epidemiological studies and preliminary results of studies being currently underway allow to delimitate the problem. the at-risk populations are localized in the parisian area, in provence-côte d'azur, in the lyon and grenoble areas, in lorraine, alsace and the ... | 1991 | 1766851 |