| somocystinamide a, a novel cytotoxic disulfide dimer from a fijian marine cyanobacterial mixed assemblage. | [reaction: see text] bioassay-guided investigation of the extract from a lyngbya majuscula/schizothrix sp. assemblage of marine cyanobacteria led to the discovery of somocystinamide a (1), an extraordinary disulfide dimer of mixed pks/nrps biosynthetic origin. somocystinamide a (1) was highly acid-sensitive, rapidly and completely converting to a characterizable derivative (2). compound 1 exhibits significant cytotoxicity against mouse neuro-2a neuroblastoma cells (ic50 = 1.4 microg/ml), whereas ... | 2002 | 11922791 |