| [in vitro and in vivo effects of a long-acting anti-influenza agent cs-8958 (laninamivir octanoate, inavir) against pandemic (h1n1) 2009 influenza viruses]. | laninamivir is a novel neuraminidase inhibitor of influenza viruses and it has been reported that its prodrug, cs-8958 shows a long-lasting characteristics. using viruses isolated in nagasaki of pandemic (h1n1) 2009 influenza virus which cause pandemic in 2009, it was shown that laninamivir has a strong inhibitory activities against their neuraminidases and virus replication in cultured cells, and strong binding stability to the virus na. furthermore, a single intranasal administration of cs-895 ... | 2010 | 21268406 |
| risk estimation based on germ-cell mutations in animals. | the set of mouse germ cell mutation rate results following spermatogonial exposure to high dose rate irradiation have been presented as the most relevant experimental results upon which to extrapolate the expected genetic risk of offspring of the survivors of the hiroshima and nagasaki atomic bombings. results include mutation rates to recessive specific-locus, dominant cataract, protein-charge, and enzyme-activity alleles. the mutability as determined by the various genetic end points differed: ... | 1989 | 2698841 |
| malignant tumors during the first 2 decades of life in the offspring of atomic bomb survivors. | the risk of cancer (incidence) prior to age 20 years has been determined for children born to atomic bomb survivors and to a suitable comparison group. tumor ascertainment was through death certificates and the tumor registries maintained in hiroshima and nagasaki. the rationale for the study stemmed from the evidence that a significant proportion of such childhood tumors as retinoblastoma and wilms tumor arise on the basis of a mutant gene inherited from one parent plus a second somatic cell mu ... | 1990 | 2160192 |
| [invitation to faculty of pharmaceutical sciences, nagasaki international university]. | | 2008 | 18575233 |
| characterization of bacterium isolated from the sediment at coastal area of omura bay in japan and several biological activities of pigment produced by this isolate. | recently we discovered a bacterial strain (ms-02-063) that produces large amounts of red pigment from coastal area of nagasaki prefecture, japan. comparative 16s rdna gene sequencing analysis revealed that strain ms-02-063 was phylogenetically closely related to gamma-proteobacterium hahella sp. mbic 3957 that produces prodigiosin. however, some physiological and biochemical differences between strain ms-02-063 and hahella sp. mbic 3957 were observed. the red pigment (rp-063) produced by this is ... | 2005 | 15905602 |
| on the lack of genetic damage in hiroshima and nagasaki. or is the mouse a good model for man? | | 1984 | 6724925 |
| implications of the hiroshima-nagasaki genetic studies for the estimation of the human "doubling dose" of radiation. | since 1946 a continuous effort to evaluate the potential genetic effects of the atomic bombs has been sustained. observations on children born in hiroshima and nagasaki include sex ratio, congenital malformations, stillbirths, survival of liveborn infants, chromosomal abnormalities (sex chromosomal abnormalities and balanced chromosomal rearrangements), mutations altering protein structure or activity, and physical growth and development. there are no statistically significant differences betwee ... | 1989 | 2698842 |
| [survey of food poisoning incidents in japan due to ingestion of marine boxfish and their toxicity]. | from 1990 to 2008, 9 food poisoning incidents due to ingestion of marine boxfish occurred in nagasaki, miyazaki, mie and kagoshima prefectures, japan, and a total of 13 persons were poisoned. their main symptom was severe muscle pain arising from rhabdomyolysis, which was usually accompanied by the discharge of black urine and abnormal elevation of serum creatine phosphokinase. twelve out of the 13 victims recovered in a few days to two months, while one died after approximately 2 weeks. since t ... | 2009 | 19897955 |
| [toxicity and toxin profile of tetrodotoxin detected in the scavenging gastropod nassarius (alectrion) glans "kinshibai"]. | from september 2007 to january 2008, a total of 66 specimens of 7 gastropod species, nassarius (alectrion) glans (n=22), bufonaria rana (n=11), ficus subintermedia (n=10), stellaria (onustus) exutus (n=8), tonna luteostoma (n=7), hemifusus tuba (n=4) and semicassis bisulcata persimilis (n=4), were collected from tachibana bay, nagasaki prefecture, japan, and their toxicity was determined by mouse bioassay. among the gastropods tested, all n. glans specimens were toxic, whereas no other species s ... | 2009 | 19325222 |