| long-term efficacy of 2 year who multiple drug therapy (mdt) in multibacillary (mb) leprosy patients. | relapse rate estimates after 2 year who multiple drug therapy (mdt) in multi-bacillary (mb) leprosy vary. between 1987 and 1994, 500 mb leprosy patients completing 2 year mdt were enrolled in a prospective relapse study. the majority of patients (n = 316) were treated and followed at the physician-staffed cebu skin clinic (csc), whereas others (n = 184) received therapy from government clinics and were followed by csc technicians in the field. relapse definition was an increased bacteriologic in ... | 2003 | 14763888 |
| the frequency of drug resistance mutations in mycobacterium leprae isolates in untreated and relapsed leprosy patients from myanmar, indonesia and the philippines. | the magnitude of drug resistance in mycobacterium leprae to dapsone, rifampicin, and ofloxacin was studied in three southeast asian countries with a high prevalence of leprosy. | 2007 | 18309708 |
| long-term relapse risk of multibacillary leprosy after completion of 2 years of multiple drug therapy (who-mdt) in cebu, philippines. | from 1987 to 1994, we enrolled 500 subjects completing 2-year who multiple drug therapy (mdt) for multibacillary leprosy in a prospective relapse study. relapse was defined as new skin lesions and an increase in the bacterial index (bi) > or = 2+ (> or = 100x) at any single slit-skin smear site. at the study end in 2006, follow-up was 6,401 subject-years, a mean of 12.8 years/subject. we observed 23 relapses, 6-16 years after mdt (mean, 10.5 years; 95% confidence interval [ci], 9.2-11.8), peakin ... | 2009 | 19861628 |