| antiplasmodial activity of new caledonia and vanuatu traditional medicines. | with the emergence of strains multiresistant to antimalarial drugs, the search for new active molecules remains a priority. ethnopharmacology appears to be a good method of selection in such investigations. | 2011 | 21284535 |
| in vitro antiplasmodial activity of extracts of tristaniopsis species and identification of the active constituents: ellagic acid and 3,4,5-trimethoxyphenyl-(6'-o-galloyl)-o-beta-d-glucopyranoside. | screening of plants from new caledonia for antiplasmodial activity against plasmodium falciparum revealed that methanolic extracts of the leaves and bark of tristaniopsis calobuxus, t. yateensis, and t.glauca inhibited the growth of chloroquine-sensitive and -resistant clones. ellagic acid and the new compound 3,4,5-trimethoxyphenyl-(6'-o-galloyl)-o-beta-d-glucopyranoside were identified as the active constituents (ic50 0.5 and 3.2 microm, respectively). the growth inhibition of both clones was ... | 2001 | 11374952 |
| [29 cases of malaria introduced into new caledonia from 1992 to 1995]. | although located in a tropical zone of the south pacific, the island of new caledonia is malaria-free. this retrospective study of imported malaria was conducted jointly by the pasteur institute of new caledonia and the gaston bourret territorial hospital between january 1, 1992 and december 31, 1995. a total of 29 patients were hospitalized for malaria. most contracted the disease in vanuatu. plasmodium vivax was involved more often than plasmodium falciparum (22 vs. 11). no case was severe, co ... | 1997 | 9289613 |
| new 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrimidinium alkaloids (phloeodictynes) from the new caledonian shallow-water haplosclerid sponge oceanapia fistulosa. structural elucidation from mainly lc-tandem-ms-soft-ionization techniques and discovery of antiplasmodial activity. | we report here on new 6-hydroxy-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrimidinium alkaloids, belonging to the phloeodictyne family, isolated from the haplosclerid sponge oceanapia[=phloeodictyon]fistulosa(bowerbank, 1873) from new caledonian shallow waters. online lc-esi-ms analysis, coupled to tandem fragmentation experiments on the crude alkaloid mixture, allowed us to clarify their flat structures, including structural isomers. at least 25 different components, of which 17 are new members with var ... | 2004 | 14985819 |
| alisiaquinones and alisiaquinol, dual inhibitors of plasmodium falciparum enzyme targets from a new caledonian deep water sponge. | four new meroterpenes, alisiaquinones a-c (1-3) and alisiaquinol (4), were isolated from a new caledonian deep water sponge. their structures and relative stereochemistry were elucidated by spectroscopic data analysis. they are related to xestoquinone, but showed unusual substitution on a tetrahydrofuran junction. they displayed micromolar range activity on two enzymatic targets of importance for the control of malaria, the plasmodial kinase pfnek-1 and a protein farnesyl transferase, as well as ... | 2008 | 18512987 |
| antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from new caledonian gardenia species (rubiaceae). | a series of 16 flavonoids were isolated and prepared from bud exudate of gardenia urvillei and gardenia oudiepe, endemic to new caledonia. most of them are rare polymethoxylated flavones. some of these compounds showed noticeable activity against leishmania (leishmania) amazonensis, plasmodium falciparum and trypanosoma brucei gambiense, in addition to tubulin polymerization inhibition at low micromolar concentration. we also provide a full set of nmr data as some of the flavones were incomplete ... | 2015 | 25659770 |