Publications

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[seroepidemiologic evaluation of malaria in mayotte (comoro archipelago) 1984-1988].in the context of a research programme on the immunology of malaria in the islands of the south-west of the indian ocean, seroepidemiological studies by means of sampling surveys have been carried out annually in mayotte island (comoro archipelago) from 1984 to 1988. apart from the transient character of the increases in rates in the wake of the epidemic outbreak of 1984, the evolution of the antibody geometric mean reciprocal titre (gmrt) by age reveals a negativation of population at large, fa ...19902085912
short report: high prevalence of multidrug-resistant plasmodium falciparum malaria in the french territory of mayotte.a drug-resistance survey was conducted in the french territory of mayotte in the comorian islands in the indian ocean where malaria is endemic. a high prevalence of resistant plasmodium falciparum parasites was observed, not only to chloroquine (88%) and pyrimethamine (99%), but more surprisingly to quinine (17%), mefloquine (9%), and amodiaquine (24%). this leaves few treatment alternatives other than artemisine-mefloquine combinations. however, despite notification to french health authorities ...200415211004
[can the thick drop/smear examination for malaria be replaced by a rapid diagnostic test in first intention? the mayotte experience].malaria is a public health problem in the french island of mayotte (160,000 inhabitants) in the indian ocean. in the late 1990, resistance to chloroquine greatly increased, and so did the number of malaria cases, so that a new health policy had to be adopted. since 2001, the initial smear/thick drop examination, the results of which took too long to obtain, has systematically been replaced by a rapid diagnosis test (optimal it diamed) in all hospitals and public health centers.200918951743
efficacy of artemether-lumefantrine treatment in patients with acute uncomplicated falciparum malaria in mayotte, a french collectivity of the comoros archipelago.mayotte is a french island located in the comoros archipelago in the indian ocean. due to the high level of resistance to chloroquine and sulfadoxine-pyrimethamine in this area, new therapeutic strategies are required. the aim was to assess and to document the efficacy of artemether-lumefantrine (al) combination in four oral dosages. the follow-up was carried out during 21 days to monitor the antimalarial drug efficacy in an open trial in april-may, 2002. results were obtained from 51 patients, ...200415490758
[rapid detection of malaria and p. falciparum chemoresistant genotypes in mayotte, 2001]. 200212355993
[a case of chloroquine-resistant (r1) falciparum malaria from the east african comoros islands (author's transl)].an african from the comoros islands, who has been living in berlin for eleven years and who had made his last journey to africa two years before, fell ill with high fever upon returning from a visit to mayotte and grande comore. his blood smear revealed trophozoites of plasmodium falciparum. after intake of 25 mg of chloroquine base per kg body weight within 66 hours, defervescence and clearance of blood ensued and by the fourth day after start of treatment the parasites could no longer be detec ...19806993367
integrated malaria control achieves results in mayotte.a malaria control campaign in the island territory of mayotte has achieved remarkable success owing to the integration of activities with the general health service and to the high degree of decentralization practised.19892692591
[in vivo study of chloroquine resistance of plasmodium falciparum malaria in mayotte].according to the existence of plasmodium falciparum chloroquine-resisting cases in madagascar and, someone, in the comoro archipelago, a study using in vivo w.h.o. test was conducted in mayotte island. between the end of 1985 and 1987, despite the great difficulties for ambulatory blood collection in a rural population, 24% of malaria cases had been followed up during 28 days, using a dose of 25 mg/kg in 3 days. during 1986 and 1987, 5 cases showed positive serology of thin blood films. either t ...19892657314
adaptive differentiation of plasmodium falciparum populations inferred from single-nucleotide polymorphisms (snps) conferring drug resistance and from neutral snps.theoretical and experimental data support the geographic differentiation strategy as a valuable tool for detecting loci under selection. in the context of plasmodium falciparum malaria, few populations have been studied, with limited genomic coverage.201020726766
[is the antimalarial fight effective in mayotte?]. 200818786803
[malaria in mayotte: epidemiology, diagnostic, prevention and treatment].mayotte is a little french island, located in the indian ocean, between madagascar and mozambic. officially there is a population of 150000 inhabitants, but in fact, there are probably about 200000 people, largely due to numerous illegal immigrants, especially coming from anjouan the nearest comorian island. there is only one hospital, with 252 beds. the malaria incidence reaches about 3000 cases per year; and treatments until august 2001 were generally haphazard. this is changing with the use o ...200417304748
[epidemiology and prevention of malaria in the southwestern islands of the indian ocean].malaria epidemiology differs greatly in the geographically close islands of the southwestern indian ocean. in madagascar and the comoros union malaria is still a major public health problem. in mayotte indigenous transmission resumed in 1995 and is currently high in some communities. in the mascarene islands (reunion and mauritius), indigenous transmission has been eradicated (reunion) or become rare (mauritius). the seychelles islands are malaria-free since local conditions are unfavorable for ...200616924826
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