| construction of an infectious cdna clone of avian hepatitis e virus (avian hev) recovered from a clinically healthy chicken in the united states and characterization of its pathogenicity in specific-pathogen-free chickens. | a genetically distinct strain of avian hepatitis e virus (avian hev-va strain) was isolated from a healthy chicken in virginia, and thus it is important to characterize and compare its pathogenicity with the prototype strain (avian hev-prototype) isolated from a diseased chicken. here we first constructed an infectious clone of the avian hev-va strain. capped rna transcripts from the avian hev-va clone were replication-competent after transfection of lmh chicken liver cells. chickens inoculated ... | 2011 | 20708350 |
| comparative pathogenesis in specific-pathogen-free chickens of two strains of avian hepatitis e virus recovered from a chicken with hepatitis-splenomegaly syndrome and from a clinically healthy chicken. | avian hepatitis e virus (avian hev) is the primary causative agent of hepatitis-splenomegaly (hs) syndrome in chickens. recently, a genetically unique strain of avian hev, designated avian hev-va, was recovered from healthy chickens in virginia. the objective of this study was to experimentally compare the pathogenicity of the prototype strain recovered from a chicken with hs syndrome and the avian hev-va strain in specific-pathogen-free chickens. an infectious stock of the avian hev-va strain w ... | 2009 | 19570623 |