| population-based analysis of actinobacillus pleuropneumoniae apxiva for use as a diva antigen. | apxiva is an rtx toxin of actinobacillus pleuropneumoniae that is a candidate antigen to differentiate infected from vaccinated animals (diva). insertion of isapl1 into the apxiva gene is known to compromise an apxiva-based diva approach, as is potentially a tgg to tga mutation in the apxiva gene. isapl1 was found in 63/349 (18.1%) a. pleuropneumoniae isolates from england and wales including serovars 2, 3, 6-8 and 12. no isapl1 insertions into apxiva were found. only two serovar 3 isolates cont ... | 2010 | 20483193 |