| construction of an infectious cdna clone of avian hepatitis e virus (avian hev) recovered from a clinically healthy chicken in the united states and characterization of its pathogenicity in specific-pathogen-free chickens. | a genetically distinct strain of avian hepatitis e virus (avian hev-va strain) was isolated from a healthy chicken in virginia, and thus it is important to characterize and compare its pathogenicity with the prototype strain (avian hev-prototype) isolated from a diseased chicken. here we first constructed an infectious clone of the avian hev-va strain. capped rna transcripts from the avian hev-va clone were replication-competent after transfection of lmh chicken liver cells. chickens inoculated ... | 2011 | 20708350 |
| heterogeneity and seroprevalence of a newly identified avian hepatitis e virus from chickens in the united states. | we recently identified and characterized a novel virus, designated avian hepatitis e virus (avian hev), from chickens with hepatitis-splenomegaly syndrome (hs syndrome) in the united states. avian hev is genetically related to but distinct from human and swine hevs. to determine the extent of genetic variation and the seroprevalence of avian hev infection in chicken flocks, we genetically identified and characterized 11 additional avian hev isolates from chickens with hs syndrome and assessed th ... | 2002 | 12409397 |
| comparative pathogenesis in specific-pathogen-free chickens of two strains of avian hepatitis e virus recovered from a chicken with hepatitis-splenomegaly syndrome and from a clinically healthy chicken. | avian hepatitis e virus (avian hev) is the primary causative agent of hepatitis-splenomegaly (hs) syndrome in chickens. recently, a genetically unique strain of avian hev, designated avian hev-va, was recovered from healthy chickens in virginia. the objective of this study was to experimentally compare the pathogenicity of the prototype strain recovered from a chicken with hs syndrome and the avian hev-va strain in specific-pathogen-free chickens. an infectious stock of the avian hev-va strain w ... | 2009 | 19570623 |