Publications

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porcine respiratory disease in the western cape province.the aetiology and pathogenesis of respiratory syndromes in pigs are reviewed with emphasis on the role of environmental factors and diagnosis. therapeutic and control measures are suggested and the cost of various regimens is dealt with in detail.1977195053
intestinal parasitic infestation in urban and rural xhosa children. a comparative study.evidence of helminthic intestinal parasites was found in 97,0% of stools of 544 xhosa schoolchildren living in cape town. the commonest parasite was trichuris trichiura, which infested 89,9% of the children. in contrast, only 9,8% of 387 xhosa children living in the tsolo district, transkei, had evidence of intestinal parasites in their stools, hymenolepis nana being the commonest. in spite of the unsatisfactory sanitary conditions in the tsolo area compared with those in guguletu, cape town, wh ...1979462313
parasitic infestation in cape town children. a random study of 101 patients.over a 12-month period random stool specimens were collected from 101 children admitted to the trauma unit of the red cross war memorial children's hospital, cape town. the majority of the children were resident on the cape flats or in mitchell's plain. examination of the stools showed evidence of parasitic infestation in 46 of the children, of whom 39 harboured ascaris lumbricoides (8), trichuris trichiura (11) or both (20). cysts of giardia lamblia were identified in 8 patients. these findings ...19892772766
allergic asthma in different population groups in the western cape. causative and complicating factors.allergic asthma is a disease with a well-defined aetiology, the recognition and elimination of which could be achieved with relatively simple and inexpensive prophylactic treatment. some of the well-known factors--respiratory tract infections, exposure to cigarette smoke, specific antigens and regular application of prophylactic treatment--which could cause or complicate asthma were studied in groups of white and coloured patients. more respiratory tract infections occurred in coloured patients ...19883340935
epidemiological aspects of liver abscesses in children in the western cape province of south africa.a high incidence (28 per 100,000 admissions) of liver abscesses is reported in children from the western cape province of south africa. of a total of 84 childhood hepatic abscesses over a 10-year period, 51 per cent (43 patients) were primary pyogenic, 30 per cent (25 patients) amoebic, 2 per cent (two patients) ascaris, and 17 per cent (14 patients) were culture negative. protein calorie malnutrition was evident in 56 per cent of cases. amoebic abscesses originated in patients from rural areas, ...19979143181
bronchial hyper-responsiveness and atopy in urban, peri-urban and rural south african children.twenty years ago, the prevalence of atopic sensitization and bronchial hyper-responsiveness (bhr) in xhosa children in a rural location in south africa was very low. the aim of this study was to document the current prevalence of these two indices by comparing traditional rural xhosa children, recently urbanized xhosa children and established city white children, and to consider factors that may account for the observed increase in all of these groups. one thousand four hundred and fifty-seven s ...200314641609
efficacy of albendazole against the whipworm trichuris trichiura--a randomised, controlled trial.to test the efficacy of albendazole against the whipworm trichuris trichiura for school-based deworming in the south-western cape, south africa. children infected with trichuris were randomised to 3 doses of albendazole (400, 800 or 1200 mg), each repeated 4 times. the boy/girl ratio was 1. a group not infected with worms was treated with placebo, creating a negative control.200415662995
paradoxical helminthiasis and giardiasis in cape town, south africa: epidemiology and control.south africa has endorsed a world health assembly (wha) resolution calling for control of soil-transmitted helminths (sths). in cape town, services and housing that exist in old-established suburbs should minimise the prevalence of intestinal parasitic infections, even when residents are poor. where families live in shacks in densely-populated areas without effective sanitation, more than 90% of children can be infected by sths. the humoral immune response to worms theoretically favours infectio ...200516006220
paradoxical helminthiasis and giardiasis in cape town, south africa: epidemiology and control.south africa has endorsed a world health assembly (wha) resolution calling for control of soil-transmitted helminths (sths). in cape town, services and housing that exist in old-established suburbs should minimise the prevalence of intestinal parasitic infections, even when residents are poor. where families live in shacks in densely-populated areas without effective sanitation, more than 90% of children can be infected by sths. the humoral immune response to worms theoretically favours infectio ...200516246001
recall of intestinal helminthiasis by hiv-infected south africans and avoidance of possible misinterpretation of egg excretion in worm/hiv co-infection analyses.ascariasis and hiv/aids are often co-endemic under conditions of poverty in south africa; and discordant immune responses to the respective infections could theoretically be affecting the epidemic of hiv/aids in various ways. it is well-known that sensitisation to helminthic antigens can aggravate or ameliorate several non-helminthic diseases and impair immunisation against cholera, tetanus and tuberculosis. the human genotype can influence immune responses to ascaris strongly. with these factor ...200616725057
ascaris, co-infection and allergy: the importance of analysis based on immunological variables rather than egg excretion.the ratio of ascaris seropositivity to the presence of eggs in the faeces was 2.44 in children residing near cape town, south africa. similar and larger ratios have previously been described for children and women living in the city. the new finding strengthens the concept that when helminthic infections occur together with non-helminthic diseases, an analysis of the interaction must include the use of disease-related immunological variables and not be based only on egg excretion status. one of ...200717254621
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