| identification of fda-approved drugs and bioactives that protect hair cells in the zebrafish (danio rerio) lateral line and mouse (mus musculus) utricle. | the hair cells of the larval zebrafish lateral line provide a useful preparation in which to study hair cell death and to screen for genes and small molecules that modulate hair cell toxicity. we recently reported preliminary results from screening a small-molecule library for compounds that inhibit aminoglycoside-induced hair cell death. to potentially reduce the time required for development of drugs and drug combinations that can be clinically useful, we screened a library of 1,040 fda-approv ... | 2009 | 19241104 |
| spatial and temporal patterns of surface water quality and ichthyotoxicity in urban and rural river basins in texas. | the double mountain fork brazos river (texas, usa) consists of north (nf) and south forks (sf). the nf receives urban runoff and twice-reclaimed wastewater effluent, whereas the sf flows through primarily rural areas. the objective of this study was to determine and compare associations between standard water quality variables and ichthyotoxicity at a landscape scale that included urban (nf) and rural (sf) sites. five nf and three sf sites were sampled quarterly from march 2008 to march 2009 for ... | 2012 | 22682267 |