| genotypic dominance and novel recombinations in hbv genotype b and c co-infected intravenous drug users. | pathogenic differences among hepatitis b virus (hbv) genotypes have been documented. however, the interaction between different hbv genotypes remains unclear. herein, we chose hbv genotypes b (hbv/b) and c (hbv/c) co-infected intravenous drug users to study this issue. hbv genotype was determined in 40 hbsag, anti-hcv, and anti-hdv co-positive intravenous drug users by using genotype-specific primers. the distribution of hbv genotype was as follows: hbv genotype b alone in 29 (72.5%); hbv genoty ... | 2004 | 15042642 |
| associations between hepatitis b virus genotype and mutants and the risk of hepatocellular carcinoma. | the risk of hepatocellular carcinoma (hcc) increases with increasing level of hepatitis b virus (hbv) in serum (viral load). however, it is unclear whether genetic characteristics of hbv, including hbv genotype and specific genetic mutations, contribute to the risk of hcc. we examined the hcc risk associated with hbv genotypes and common variants in the precore and basal core promoter (bcp) regions. | 2008 | 18695135 |
| hepatitis b virus genotype b has an earlier emergence of lamivudine resistance than genotype c. | hepatitis b virus (hbv) genotype b and c seem not to affect the therapeutic response to lamivudine (3tc). whether a given genotype has an earlier emergence of 3tc resistance remains unclear. we thus conducted this study to elucidate the association of hbv genotype with the emergence of 3tc-resistant strains in taiwanese patients. | 2009 | 20032545 |
| predicting hepatitis b virus (hbv) surface antigen seroclearance in hbv e antigen-negative patients with chronic hepatitis b: external validation of a scoring system. | hepatitis b virus (hbv) surface antigen (hbsag) seroclearance is the ultimate serological end point in chronic hepatitis b. this study aimed to develop and validate a prediction score for spontaneous hbsag seroclearance in hbv e antigen (hbeag)-negative patients with chronic hepatitis b due to hbv genotype b or c. | 2015 | 25430663 |
| aboriginal taiwanese hepatitis b carriers have more favorable viral factors than han chinese carriers. | several viral factors are associated with disease progression in hepatitis b virus (hbv) carriers. compared with taiwanese han chinese, taiwanese aborigines have a higher prevalence of chronic hbv infection and a higher standardized mortality rate of chronic liver diseases but a lower standardized mortality rate of hepatocellular carcinoma (hcc). the aim of this study was to investigate whether aboriginal taiwanese hbv carriers have more favorable viral factors which reduce the risk for hcc than ... | 2011 | 21678436 |
| hepatitis b virus genotype b results in better immediate, late and sustained responses to peginterferon-alfa in hepatitis-b-e-antigen-positive patients. | this study investigated outcome predictors in hepatitis-b-e-antigen (hbeag)-positive chronic hepatitis b patients treated with peginterferon alfa-2a. | 2011 | 21332543 |
| high prevalence of occult hepatitis b virus infection in taiwanese intravenous drug users. | the epidemiology and impact of occult hbv infection in intravenous drug users remain largely unknown. the aim of the study was to investigate the prevalence of occult hbv infection among intravenous drug users in taiwan. molecular assays were used to determine the level of serum hbv dna and the genotype in 304 intravenous drug users negative for both hbsag and anti-hcv. of 304 intravenous drug users, 125 (41.1%) were positive for serum hbv dna. the genotype distribution of hbv was as follows: b, ... | 2007 | 17854041 |
| hepatitis b virus genotypes and spontaneous hepatitis b e antigen seroconversion in taiwanese hepatitis b carriers. | hepatitis b virus (hbv) is classified into eight genotypes (a-h), and genotype c is associated with more aggressive liver disease compared to genotype b. however, the mechanisms responsible for the clinical differences remain unclear. to test whether genotype c patients had with lower rates of spontaneous hepatitis b ge antigen (hbeag) seroconversion than genotype b patients, stored serum samples from 146 taiwanese adult hbeag-positive hepatitis b carriers followed-up for a mean of 52 months (ra ... | 2004 | 14748059 |