| hpv prevalence, e6 sequence variation and physical state of hpv16 isolates from patients with cervical cancer in sichuan, china. | infection with high-risk human papillomavirus (hr-hpv) is an important factor associated with cervical cancer. the genetic mutation of hpv16 e6 and integration of hpv16 dna in the cervical carcinoma tissues are considered important genetic changes in cervical lesion progression. but the studies of hr-hpv epidemiology are relatively less in the area of sichuan, china. therefore, we investigated the prevalence of 9 high-risk subtypes and analyzed the genetic mutation characteristic of hpv16 e6 and ... | 2007 | 16970982 |
| analysis of mutations in the urr and e6/e7 oncogenes of hpv 16 cervical cancer isolates from central china. | high rates of cervical cancer have been reported from parts of china and this may reflect a predominance of cervical infection with particularly aggressive human papillomavirus (hpv) variants. this pcr-based investigation of cervical tumours from sichuan province in central china demonstrated an hpv positivity rate of 88%. hpv 16 was most common (21/34, 61%), followed by hpv 18 (3/34, 9%), while types 33, 45, 58 and 59 were each identified in one specimen. sequencing of up to 1349 bases of the 2 ... | 2000 | 10797293 |