| unusual physiology of scale-less carp, gymnocypris przewalskii, in lake qinghai: a high altitude alkaline saline lake. | the scale-less carp (gymnocypris przewalskii) inhabits lake qinghai located on the qinghai-tibet plateau (elevation, 3200 m) in western china. the lake waters are alkaline (ph 9.4, titratable alkalinity=30 mmol l(-1)), mg(2+)-rich (18.7 mmol l(-1)), ca(2+)-poor (0.30 mmol l(-1)) and saline (9 per thousand ). these fish make annual spawning migrations into freshwater rivers. we investigated the physiology of nitrogen excretion and ionoregulation of fish from the lake and river. fish from both wat ... | 2003 | 12547271 |
| mitochondrial cytochrome b sequence variation and phylogenetics of the highly specialized schizothoracine fishes (teleostei: cyprinidae) in the qinghai-tibet plateau. | the complete 1140 bp mitochondrial cytochrome b sequences were obtained from 39 individuals representing five species of all four genera of highly specialized schizothoracine fishes distributed in the qinghai-tibet plateau. sequence variation of the cytochrome b gene was surveyed among the 39 individuals as well as three primitive schizothoracines and one outgroup. phylogenetic analysis suggested that the group assignment based on 1140 bp of the cytochrome b sequence is obviously different from ... | 2006 | 16941235 |
| evolution and regulation of the downstream gene of hypoxia-inducible factor-1alpha in naked carp (gymnocypris przewalskii) from lake qinghai, china. | the naked carp (gymnocypris przewalskii) is a native teleost of lake qinghai (altitude, 3.2 km) on the qinghai-tibet plateau in china. hypoxia-inducible factor (hif)-1alpha of gymnocypris przewalskii was cloned and a phylogenetic tree for vertebrate hif-1alpha was constructed. by analysis of maximum likelihood models of codon substitutions for hif-1alpha, three positive sites in the branch lineages of crucian carp, eelpout, and flounder, and a higher proportion of neutral sites in naked carp, an ... | 2008 | 18941827 |
| growth hormone and insulin-like growth factor of naked carp (gymnocypris przewalskii) in lake qinghai: expression in different water environments. | here, we report the cloning and characterization of growth hormone (gh), insulin-like growth factor-i (igf-i) and igf-ii from naked carp (gymnocypris przewalskii), a native teleost fish of lake qinghai in the qinghai-tibet plateau of china. the gh of naked carp encodes for a predicted amino acid sequence showing identities of 63%, 63%, 91% and 94% with cherry salmon, rainbow trout, zebrafish and grass carp, respectively. compared to common carp and goldfish, evolutionary analysis showed that gen ... | 2009 | 19233187 |
| positive darwinian selection within interferon regulatory factor genes of gymnocypris przewalskii (cyprinidae) on the tibetan plateau. | tibetan plateau (tp) had experienced phased uplift, resulting in inhospitable environment of low temperature, hypoxia and high ultraviolet radiation for tibetan wildlife. many organisms can well adapt to tp, it is of ecological and evolutionary interest to untangle how organisms adapt to extreme environment on tp through evolution. previous studies mainly focused on hypoxia and metabolism related genes, but we know little about the evolutionary history of immune genes in tibetan wildlife. in thi ... | 2016 | 26774494 |
| cloning and characterization of two subunits of calcineurin cdna in naked carp (gymnocypris przewalskii) from lake qinghai, china. | the naked carp (gymnocypris przewalskii), a native teleost, plays an important role in maintenance of the ecological balance in the system of lake qinghai (altitude, 3.2 km) on the qinghai-tibet plateau in china. calcineurin (cn) is the only member of the serine/threonine phosphatase family that can be activated by both ca2+ and calmodulin (cam) and involved in many important physiological processes such as salt tolerance/adaption. in this report, cdnas of cn catalytic subunit paralogue isoforms ... | 2014 | 25308739 |
| transcriptome-wide identification, molecular evolution and expression analysis of toll-like receptor family in a tibet fish, gymnocypris przewalskii. | toll-like receptors (tlr) are key components of innate immunity that play significant roles in immune defense against pathogens invasion. recent frequent outbreaks of the "white spot disease" caused by parasitic infection in farmed tibetan fishes had resulted in great economic losses. however, to our knowledge, the roles of tlrs in mediating immune response to parasitic infection in tibetan fishes remain to be determined. here, we performed data-mining on a widely-farmed tibetan fish (gymnocypri ... | 2015 | 26102458 |
| genome-wide identification of genes probably relevant to the adaptation of schizothoracins (teleostei: cypriniformes) to the uplift of the qinghai-tibet plateau. | molecular adaptation to the severe environments present during the uplift of the qinghai-tibet plateau has attracted the attention of researchers. the divergence of the three specialization groups of schizothoracins (primitive, specialized and highly specialized) may correspond to the three phases of plateau uplift. based on the transcripts of representative species of the three specialized groups and an outgroup, genes in schizothoracins that may have played important roles during the adaptatio ... | 2017 | 28427344 |
| characterization of two paralogous myostatin genes and evidence for positive selection in tibet fish: gymnocypris przewalskii. | myostatin (mstn) is an important member of tgf-β superfamily, a muscle growth inhibitor. though mstn has been identified in many organisms, little is known about this gene in highland fish, gymnocypris przewalskii endemic to the qinghai-tibetan plateau. in this study, we first cloned two paralogous mstn genes (mstn1 and mstn2) from g. przewalskii through homologue cloning. the 3d structures of both mstn proteins varied in the numbers of β-sheets and conformations of α-helices. the branch-site mo ... | 2015 | 25861868 |