| antibodies to borrelia burgdorferi in rodents in the eastern and southern united states. | serologic studies were conducted to determine whether white-footed mice (peromyscus leucopus) and cotton mice (peromyscus gossypinus) contained serum antibodies to borrelia burgdorferi, the causative agent of lyme borreliosis. enzyme-linked immunosorbent assays detected antibodies to this spirochete in 35.7 and 27.3% of 56 p. leucopus and 535 p. gossypinus serum samples, respectively, collected in connecticut, north carolina, south carolina, georgia, florida, alabama, and mississippi. antibody t ... | 1992 | 1624561 |
| serologic analyses of peromyscus leucopus, a rodent reservoir for borrelia burgdorferi, in northeastern united states. | an enzyme-linked immunosorbent assay (elisa) and indirect fluorescent-antibody test were used to detect antibodies to borrelia burgdorferi, the causative agent of lyme disease, in peromyscus leucopus (white-footed mouse). of the 661 mice captured in connecticut, rhode island, and new york during 1980 and 1983 to 1987, 166 (25.1%) had antibodies to b. burgdorferi by elisa. comparative analyses of 210 serum specimens, collected in areas where lyme disease is endemic, revealed a threefold differenc ... | 1988 | 3384925 |
| endemicity of spotted fever group rickettsiae in connecticut. | to compare rickettsial infectivity and seropositivity rates against spotted fever group (sfg) rickettsiae, ticks and wild mammals were collected from three areas where rickettsia rickettsii was thought to be enzootic in connecticut during 1978-1979, and from four additional sites (with no reported human cases) between 1976 and 1979. of the 1,001 dermacentor variabilis examined by the hemolymph test, 59 (5.9%) contained rickettsia-like organisms; direct immunofluorescence tests verified the prese ... | 1981 | 6789690 |
| detection of borrelia burgdorferi in urine of peromyscus leucopus by inhibition enzyme-linked immunosorbent assay. | an inhibition enzyme-linked immunosorbent assay was developed to detect borrelia burgdorferi, the etiologic agent of lyme borreliosis, in urine from white-footed mice (peromyscus leucopus). of the 87 urine specimens tested from 87 mice collected in widely separated tick-infested sites in connecticut, 57 (65.5%) contained detectable concentrations of spirochetal antigens. forty-seven (62.7%) of 75 serum samples analyzed contained antibodies to b. burgdorferi. in culture work with tissues from bla ... | 1994 | 8195393 |
| antibodies to multiple tick-borne pathogens of babesiosis, ehrlichiosis, and lyme borreliosis in white-footed mice. | serum samples from peromyscus leucopus (white-footed mouse), collected in connecticut (usa) in 1983, 1985, and during 1990 to 1993, were analyzed by an enzyme-linked immunosorbent assay (elisa) or indirect fluorescent antibody (ifa) staining methods for antibodies to borrelia burgdorferi (strain 2591), babesia microti, ehrlichia chaffeensis (arkansas strain), and ehrlichia equi (mrk strain). of the 294 serum samples tested, 160 (54%) contained immunoglobulins to one or more of these pathogens. t ... | 1997 | 9249691 |
| serologic evidence of infection with ehrlichia spp. in wild rodents (muridae: sigmodontinae) in the united states. | rodent (muridae: sigmodontinae) blood and sera collected from 14 states were tested for seroreactivity to a cultured isolate of the human granulocytic ehrlichiosis (hge) agent by using an indirect immunofluorescence assay. of the 1,240 samples tested, 136 (11%) were found to be reactive at titers of > or = 32. rodents with hge agent-specific antibodies were found in new york (23% of 491 samples; geometric mean endpoint titer [gmt] = 441), connecticut (11% of 100 samples; gmt = 481), california ( ... | 1998 | 9508298 |
| antibodies to granulocytic ehrlichiae in white-footed and cotton mice in eastern united states. | serum samples, collected from peromyscus leucopus (white-footed mouse) or peromyscus gossypinus (cotton mouse) during 1987 through 1990 in florida, georgia, maryland, mississippi, and north carolina (usa), and in 1997 in southern connecticut were analyzed by indirect fluorescent antibody (ifa) staining methods or western blot procedures for antibodies to granulocytic ehrlichiae. of the 82 sera from white-footed mice in connecticut tested by ifa methods with either the bds or nch-1 strain of the ... | 1999 | 10231752 |
| control of immature ixodes scapularis (acari: ixodidae) on rodent reservoirs of borrelia burgdorferi in a residential community of southeastern connecticut. | a 3-yr community-based study was conducted on residential properties on mason's island, mystic, ct, to determine the efficacy of a rodent-targeted acaricide (fipronil) to control immature ixodes scapularis (say) on peromyscus leucopus. results indicated that modified commercial bait boxes were effective as an acaricide delivery method for reducing nymphal and larval tick infestations on white-footed mice by 68 and 84%, respectively. passive application of fipronil significantly reduced the infec ... | 2004 | 15605643 |
| presence of ixodiphagus hookeri (hymenoptera: encyrtidae) in two connecticut populations of ixodes scapularis (acari: ixodidae). | two connecticut populations of the black-legged tick, ixodes scapularis (say), the vector of lyme disease spirochetes, borrelia bugrdorferi sensu stricto johnson, schmid, hyde, steigerwalt & brenner, in the northeastern united states, are parasitized by the encyrtid wasp ixodiphagus hookeri (howard), formerly hunterellus hookeri. the wasp was first detected in ticks from a forested site in bridgeport in 1992. i. hookeri was reared from 18.6% of 148 host-seeking i. scapularis nymphs. in 1993 and ... | 1996 | 8906928 |
| analyses of mammalian sera in enzyme-linked immunosorbent assays with different strains of borrelia burgdorferi sensu lato. | blood samples were collected from cottontail rabbits (sylvilagus floridanus), raccoons (procyon lotor), white-footed mice (peromyscus leucopus), and white-tailed deer (odocoileus virginianus) between 1977 and 1991 in southern connecticut and new york state (usa) and were tested for antibodies against eight strains of borrelia burgdorferi sensu lato in enzyme-linked immunosorbent assays. among these spirochetes were six strains of b. burgdorferi sensu stricto, one strain of b. garinii (=ip90) and ... | 1995 | 8583632 |
| geographic variation in peromyscus leucopus: short-day induced reproductive regression and spontaneous recrudescence. | in order to determine if intraspecific differences exist in the photoperiodic control of the reproductive cycle of white-footed mice (peromyscus leucopus), 34 male and 60 female mice from either connecticut (ct), virginia (va), or georgia (ga) laboratory stocks were exposed to either a long (16l:8d) or short (9l:15d) photoperiod for up to 27 weeks. reproductive status (testis length or the presence of a perforate vagina) of these mice was assessed every 1 to 2 weeks. after this time, the males w ... | 1982 | 7126737 |
| avian and mammalian hosts for spirochete-infected ticks and insects in a lyme disease focus in connecticut. | spirochetes and their vectors and reservoirs were studied in a lyme disease focus in east haddam, connecticut, from mid-may through september 1983. ixodes dammini subadults were comparable in number on white-footed mice (peromyscus leucopus) (means = 2.9 +/- 3.6 sd) to those on 27 different species of birds (means = 2.3 +/- 4.2 sd) representing 11 families within the order passeriformes. less commonly found ticks on birds (means less than or equal to 0.1) were immature ixodes dentatus and haemap ... | 1984 | 6516460 |
| identification of endemic foci of lyme disease: isolation of borrelia burgdorferi from feral rodents and ticks (dermacentor variabilis). | borrelia burgdorferi, the etiological agent of lyme disease, was isolated from the blood, kidneys, spleens, eyes, or livers of white-footed mice (peromyscus leucopus) (n = 19 of 22) and from the blood, kidneys, or spleens of eastern chipmunks (tamias striatus) (n = 2 of 2) captured at three foci for lyme disease in eastern connecticut. these bacteria were cultured most frequently from spleens (n = 19) and kidneys (n = 15). b. burgdorferi persisted in one mouse for at least 60 days. one spirochet ... | 1985 | 3926816 |
| culturing borrelia burgdorferi from spleen and kidney tissues of wild-caught white-footed mice, peromyscus leucopus. | borrelia burgdorferi was isolated most frequently from tissue of spleen (n = 13) and kidney (n = 10) and less often from blood (n = 5) of wild-caught peromyscus leucopus. prevalence of infection tended to be highest at sites where lyme disease was most common (e.g., 5 of 6 mice were positive in east haddam, connecticut). spirochetes were not isolated in danbury or new hartford, areas where this malady is rare. however, in fairfield, where the disease is also uncommon, 4 of 9 mice were infected. ... | 1986 | 3577490 |
| new infectious spirochete isolated from short-tailed shrews and white-footed mice. | a spirochete with two periplasmic flagella was isolated from the blood or tissues of spleens and kidneys from short-tailed shrews (blarina brevicauda) and white-footed mice (peromyscus leucopus) in connecticut and minnesota. after inoculation, the shrew-mouse spirochete infected swiss mice and syrian hamsters. this spirochete is morphologically and serologically distinct from the species of treponema, borrelia, leptospira, and spirochaeta examined. | 1987 | 3305565 |
| new borrelia burgdorferi antigenic variant isolated from ixodes dammini from upstate new york. | a previously undescribed borrelia burgdorferi antigenic variant was isolated from each of four ixodes dammini larvae removed from white-footed mice, peromyscus leucopus, captured in millbrook, n.y. this site is in the northern range of the known distribution of the tick in the northeastern united states. the molecular weights of approximately 32,500 and 35,500 for outer surface a and outer surface b proteins, respectively, were distinctly higher than those for previously characterized isolates f ... | 1988 | 3183008 |
| ticks and biting insects infected with the etiologic agent of lyme disease, borrelia burgdorferi. | members of 18 species of ticks, mosquitoes, horse flies, and deer flies were collected in southeastern connecticut and tested by indirect fluorescent-antibody staining methods for borrelia burgdorferi, the etiologic agent of lyme disease. an infection rate of 36.2% (116 tested), recorded for immature ixodes dammini, exceeded positivity values for all other arthropod species. prevalence of infection for hematophagous insects ranged from 2.9% of 105 hybomitra lasiophthalma to 14.3% of seven hybomi ... | 1988 | 3170711 |
| geographic differences for delay of sexual maturation in peromyscus leucopus: effects of photoperiod, pinealectomy, and melatonin. | effects of short-day photoperiod, pinealectomy, and melatonin on sexual maturation were tested in peromyscus leucopus from either connecticut (ct) or georgia (ga). laboratory reared-stocks from ct and ga were exposed to short daylength (photoperiod) from birth or 25 days of age. at 12 wk of age, delay in sexual maturation was indicated in most ct mice by decreased testis length, combined testes weight, and seminal vesicle weight. conversely, ga animals did not delay sexual maturation when expose ... | 1989 | 2624861 |
| effectiveness of host-targeted permethrin in the control of ixodes dammini (acari: ixodidae) | tubes of commercially available permethrin-treated cotton balls were distributed twice each year in 1989 and 1990 at five sites in a lyme disease endemic area in connecticut. five additional sites were not treated. at each application, 48 tubes, sufficient to treat 0.4 ha, were dispersed at 10-m intervals through woodlands, around ornamental plantings, and along rockwalls. the cotton was collected by white-footed mice (peromyscus leucopus) from the majority of the tubes, which resulted in a decr ... | 1991 | 1941927 |
| babesia microti, human babesiosis, and borrelia burgdorferi in connecticut. | babesia microti was isolated from a white-footed mouse (peromyscus leucopus) that was captured in southeastern connecticut in 1988, when the first human case of babesiosis acquired in connecticut was recognized. to date, 13 cases of babesiosis have been reported in connecticut, the largest number of human cases reported on the mainland united states. two of nine patients quiried remembered a prior tick bite. since babesia parasites are known to be vectored only by ticks, we surmise that 12 of th ... | 1991 | 1757548 |
| third-year evaluation of host-targeted permethrin for the control of ixodes dammini (acari: ixodidae) in southeastern connecticut. | the impact of commercially available permethrin-treated cotton balls targeted at ixodes dammini spielman, clifford, piesman & corwin on white-footed mice, peromyscus leucopus, was evaluated for a third year at five residential sites in south-central connecticut. each site had been treated twice each year from 1989 through 1991 with sufficient product to treat 0.4 ha of mouse habitat, and results were compared with five untreated sites. there were no significant differences in the number of host- ... | 1992 | 1495085 |
| intraerythrocytic parasites in rodent populations of connecticut: babesia and grahamella species. | a total of 612 peromyscus leucopus, 11 microtus pennsylvanicus, 21 clethrionomys gapperi, and 4 tamias striatus was collected in connecticut and examined for babesia and grahamella during 1976 and 1977. babesia antibodies were detected in sera of 9 p. leucopus collected from 4 sites. babesia parasites were not detected in the blood smears of captured rodents. subsequent splenectomy and subinoculation of blood from these rodents into susceptible animals failed to induce disease and no babesia was ... | 1979 | 512755 |
| expansion of zoonotic babesiosis and reported human cases, connecticut, 2001-2010. | to document the expansion of human babesiosis in connecticut, we analyzed reservoir host sera for seroreactivity to babesia microti franca and reviewed connecticut human surveillance case data collected during 2001-2010. sera from white-footed mice, peromyscus leucopus rafinesque, from 10 towns in 5 counties, collected at 4-7-yr periods between 2001 and 2010, were tested for total immunoglobulins. the prevalence of b. microti-positive mice was compared with confirmed and probable human case repo ... | 2014 | 24605475 |
| serum antibodies to borrelia burgdorferi, anaplasma phagocytophilum, and babesia microti in recaptured white-footed mice. | a mark-release-recapture study was conducted during 2007 through 2010 in six, tick-infested sites in connecticut, united states to measure changes in antibody titers for borrelia burgdorferi sensu stricto, anaplasma phagocytophilum, and babesia microti in peromyscus leucopus (white-footed mice). there was an overall recapture rate of 40%, but only four tagged mice were caught in ≥2 yr. sera from 561 mice were analyzed for total antibodies to b. burgdorferi and a. phagocytophilum by using whole-c ... | 2013 | 23568904 |
| antibodies to whole-cell or recombinant antigens of borrelia burgdorferi, anaplasma phagocytophilum, and babesia microti in white-footed mice. | serum samples were obtained from white-footed mice (peromyscus leucopus) in tick-infested areas of connecticut during the period 2001 through 2003 and analyzed for antibodies to borrelia burgdorferi, anaplasma phagocytophilum, and babesia microti. emphasis was placed on the evaluations of highly specific recombinant vlse or protein (p) 44 antigens of b. burgdorferi and a. phagocytophilum, respectively, in a newly developed enzyme-linked immunosorbent assay (elisa) as well as testing sera with wh ... | 2006 | 17255439 |
| borrelia burgdorferi infection in a natural population of peromyscus leucopus mice: a longitudinal study in an area where lyme borreliosis is highly endemic. | blood samples from peromyscus leucopus mice captured at an enzootic site in connecticut were examined for antibodies to and dna of borrelia burgdorferi, to characterize the dynamics of infection in this reservoir population. from trappings conducted over the course of 2 transmission seasons, 598 (75%) of 801 serum samples from 514 mice were found to be positive by enzyme immunoassay. seropositivity correlated with date of capture and mouse age, was similar among locations within the site, increa ... | 2004 | 15073690 |
| comparison of the reservoir competence of medium-sized mammals and peromyscus leucopus for anaplasma phagocytophilum in connecticut. | in the northeastern united states, anaplasma phagocytophilum, the agent of human granulocytic ehrlichiosis (hge), is transmitted by the tick vector ixodes scapularis. the white-footed mouse peromyscus leucopus is a competent reservoir for this agent, but the reservoir competence of non-peromyscus hosts of i. scapularis has not been studied. here, we report data confirming reservoir competence of medium-sized mammals for a. phagocytophilum. raccoons, virginia opossums, gray squirrels, and striped ... | 2002 | 12737542 |
| antibodies to rickettsia rickettsii in peromyscus leucopus from a focus of rocky mountain spotted fever in connecticut. | during 1980-1982, white-footed mice (peromyscus leucopus) were captured in newtown, connecticut, an area where rickettsia rickettsii, the etiologic agent of rocky mountain spotted fever, is thought to be enzootic. an indirect microimmunofluorescence test identified specific antibodies to this organism in 16 of 237 (7%) sera: titration end points for 14 samples were relatively high (1:128-1:2048). antibodies were detected in mice during 1980 and 1981 with monthly prevalences varying from 8 to 22% ... | 1984 | 6744122 |