| [incidence of amantadine-resistant influenza a (genotype ser-31-asn) in nursing homes in niigata, japan]. | the antiviral agent amantadine specifically inhibit influenza a virus infection, but the emergence of drug-resistant viruses occur more readily with amantadine treatment. in human influenza viruses, single amino acid changes at 4 sites spanning the transmembrane domain of the m2 protein can confer drug resistance. amantadine was approved for treatment of parkinson's disease in 1975, and for the influenza a virus infection in november 1998, in japan. annual consumption of amantadine for influenza ... | 2000 | 11019512 |
| isolation and characterization of novel human parechovirus from clinical samples. | using vero cells, we isolated a virus (nii561-2000) from a cerebrospinal fluid specimen of a 1-year-old girl with reye syndrome. the determined amino acid sequence of the virus indicated that the isolate was a human parechovirus (hpev), a member of picornaviridae. neutralization test showed that the nii561-2000 virus had distinct antigenicity to hpev-1, hpev-2, and hpev-3, and that the sequence was distinct from these types as well as from hpev-4 and hpev-5. thus, we propose the virus (nii561-20 ... | 2007 | 17553229 |