Publications

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human infection with wuchereria bancrofti in matara, sri lanka: the use, in parallel, of an elisa to detect filaria-specific igg4 in urine and of ict card tests to detect filarial antigen in whole blood.the ict card test to detect circulating filarial antigen and an elisa that detects filaria-specific urinary igg(4) were each used to screen 473 subjects from a community in sri lanka where wuchereria bancrofti is endemic. when the ict test was used as the gold standard, the elisa was found to have a sensitivity of 91.2%. however, far more of the subjects were found elisa-positive than ict-positive (76.5% v. 31.1%). the youngest children studied (aged 1-10 years) were similar to the adult subject ...200312803873
distribution of filarial elephantiasis and hydrocele in matara district, sri lanka, as reported by local leaders, and an immunological survey in areas with relatively high clinical rates.to eliminate lymphatic filariasis by means of mass drug administration, it is essential to have reliable data on the disease distribution and prevalence in targeted areas. in matara district, sri lanka, self-administered questionnaires were mailed to 2105 local leaders questioning the presence and the numbers of elephantiasis and hydrocele cases. the information provided by them revealed that elephantiasis was clearly aggregated in the southern part of the district along the coast, while hydroce ...200818508407
the use of whole blood absorbed on filter paper to detect wuchereria bancrofti circulating antigen.the og4c3 enzyme-linked immunosorbent assay (elisa) to detect circulating wuchereria bancrofti antigen uses 50 microl of serum. in this study, a whole blood sample absorbed on filter paper was tested as a substitute for serum. serum samples were obtained from 60 sri lankan subjects by venepuncture and finger-prick blood samples from the same individuals were directly absorbed on filter paper. og4c3 elisas using serum and filter paper blood were compared. despite the fact that the estimated amoun ...19989861365
microfilarial periodicity of wuchereria bancrofti and man landing periodicity of the vector culex quinquefasciatus say in matara, sri lanka.to compare the microfilarial periodicity of wuchereria bancrofti, with the man landing periodicity of the vector culex quinquefasciatus in matara, sri lanka.19989704546
comparative efficacy of house curtains impregnated with permethrin, lambdacyhalothrin or bendiocarb against the vector of bancroftian filariasis, culex quinquefasciatus, in matara, sri lanka. 19968761561
filarial diseases in ceylon: a geographic and historical analysis.medical records concerning filarial diseases in ceylon date from the account of davy[1], though there are hints as to the more obvious manifestations in the old chronicles of the country, too. a first survey was conducted in 1912/1913 concentrating on urban areas, followed by a second survey in the 1930s with emphasis on the rural parts. the results displayed a remarkable distribution pattern: wuchereria bancrofti, the so-called "urban type", concentrated in galle and matara towns, whereas brugi ...19836152421
a study of the age-composition of natural populations of culex pipiens fatigans wiedemann in relation to the transmission of filariasis due to wuchereria bancrofti (cobbold) in ceylon.filariasis due to wuchereria bancrofti is becoming an increasingly important problem in many countries of southern and south-eastern asia. from 1962 to 1964, a study was made of the vector of this disease, culex pipiens fatigans, in two districts of colombo, ceylon, one with vector control by larviciding and one without. catches were made of the house-resting, biting and ovipositing populations, and the stages of ovarian development, parity and infection were determined by examination of the ext ...19675300045
wuchereria bancrofti antigenaemia in sri lanka.the prevalence of wuchereria bancrofti antigenaemia determined in 353 subjects in matara, sri lanka by og4c3 elisa was 20.7%. positive rates obtained with the same subjects by 1 ml nuclepore filtration and 60 microl thick blood smear were 11.3% and 7.9%, respectively. antigen levels were positively associated with microfilaria counts. two-thirds of antigen-positive and microfilaria-negative (ag+/mf-) individuals were > 25-year-old, but younger age groups (< or = 25-year-old) tended to have propo ...199910223216
epidemiology of bancroftian filariasis in three suburban areas of matara, sri lanka.the epidemiological parameters of bancroftian filariasis were investigated in three suburbs of matara, within the south-western coastal belt of sri lanka where the disease is endemic. the overall prevalence of microfilaraemia and the geometric mean density of the microfilaraemias observed were 4.4% and 20.6 microfilariae/60 microl fingerprick blood, respectively. prevalence was significantly lower in the female subjects than in the male, and in males aged < 20 years than in older males. overall, ...200111339886
prevalence and intensity of wuchereria bancrofti antigenaemia in sri lanka by og4c3 elisa using filter paper-absorbed whole blood.in sri lanka 2741 people from matara, an endemic area for wuchereria bancrofti, were examined in 1996/97 for microfilariae by 60-microl blood smear and for circulating filarial antigens by og4c3 elisa using filter paper-absorbed whole blood. the overall prevalence of microfilaraemia was 3.4%, and that of antigenaemia 14.4%. the prevalence of antigen-positive and microfilaria-negative people was 11.3%. analysed by age-group, antigenaemia prevalence was similar in all groups, and the average numbe ...200211925989
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