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the isolation of japanese encephalitis virus from taiwan mosquitoes by mosquito cell cultures and mouse inoculation. 197829127
arbovirus infections in reptiles: studies on the presence of japanese encephalitis virus antibody in the plasma of the turtle, trionyx sinensis.this study was undertaken to examine further the natural infection of poikilothermic animals e.g. turtles, to japanese encephalitis (je) virus. plasma samples from 75 soft-shelled fresh water turtles (trionyx sinensis wiegman) from china were examined in virus neutralization (vn) and hemagglutination inhibition (hai) tests for the presence of specific antibody. the total incidence of antibody detected by either test to a titer of 10 or greater was 89% while 77% and 60% were positive by vn and ha ...1975170690
japanese encephalitis surveillance in china (province of taiwan) during 1968-1971. i. geographical and seasonal features of case outbreaks.during 1968-1971 japanese encephalitis (je) surveillance was conducted with who-assisted programs in taiwan area. emphasis was placed on: (1) active case-finding by hospital visits; (2) blood collection from every patient at the suitable time; and (3) the enforcement of standard diagnostic criteria on the results of hemagglutination-inhibition tests. each year, approximately 90% of reported patients were etiologically examined. je virus etiology was established in 277 (1968), 279 (1969), 269 (19 ...1975180319
japanese encephalitis virus in northern taiwan, 1969-1973.sentinel pigs were bled and mosiquitoes were collected for isolation of japanese encephalitis virus (jev) between 1969 and 1973 in a rural area of northern taiwan which reported a high annual incidence of human cases. the study site included a farmyard, schools, a bat cave, rice paddies and a heronry. although culex annulus was collected in every month of the year, isolations were made only in midsummer and only from culex annulus and (once) from culex tritaeniorhynchus. these isolates were usua ...1976180845
host preference of mosquito vectors of japanese encephalitis.the host preference of 4 culex mosquito species collected in miaoli and pingtung counties, taiwan was studied by capillary precipitin method. antisera to alum-precipitated sera of man, bovine, swine, rabbit, horse, dog, cat, mouse, chicken, duck, and pigeon were produced in rabbits and reacted with 758 mosquito blood meals among which reactions to one or more antisera. culex annulus and culex tritaeniorhynchus summorosus showed a great avidity for pig, and culex fuscocephala for bovine. culex pi ...1975181218
prevalence of antibodies to hepatitis c virus (anti-hcv) in different populations in taiwan.the prevalence of antibodies to hepatitis c virus (anti-hcv) was investigated among different populations in taiwan, where anti-hcv was detected in 0.8% (24/2,994) of adult volunteer blood donors, 0.1% (1/1,305) of youngsters and children, 12.5% (8/64) of adult volunteer blood donors with elevated alanine aminotransferase (alt), 36.5% (23/63) of hemodialysis patients, 4.1% (13/318) of male homosexuals, 25.4% (16/63) of cases positive for antibodies to human immunodeficiency virus (anti-hiv), 82. ...19911657545
a longitudinal study of the prevalence of japanese encephalitis virus in adult and larval culex tritaeniorhynchus mosquitoes in northern taiwan.adult females and larvae of culex tritaeniorhynchus were collected year-round for 3 1/2 years at a site near taipei, taiwan. one hundred sixty-four isolates of japanese encephalitis (je) virus were obtained from approximately 142,000 adult females and 1 isolate of the virus was obtained from approximately 382,000 larvae. virus was recovered from adult females every year, except the first, beginning in may. the single larval isolate was from specimens collected in june. the vertical transmission ...19892729510
[epidemic dengue 2 on liouchyou shiang, pingtung county in 1981].during the summer of 1981, an outbreak of dengue occurred on liouchyou shiang, an islet about 15 km. southwest of taiwan. more than 12, 500 people, approximately 80% of the inhabitants, were estimated to be affected in this epidemic which had been the first dengue outbreak in taiwan since 1945. neither shock nor fatal case was found. the epidemic subsided in october and there was no confirmed dengue case in taiwan from 1982 to 1985. all the 21 virus strains isolated from the blood of patients we ...19863816365
japanese encephalitis virus surveillance in taiwan. ii. isolations from mosquitoes and bats in taipei area 1969-1970. 19714156531
a serologic survey for arbovirus antibodies in inhabitants of a southwest taiwan village. 19674296789
japanese encephalitis vaccine including a preliminary report on dengue fever and chikungunya vaccines. 19674297905
investigation of the hi titre of japanese encephalitis of swine on taiwan, republic of china. 19684301798
ecology of japanese encephalitis virus on taiwan in 1968. 19704316617
the effect of vaccination with a live attenuated strain of japanese encephalitis virus on stillbirths in swine in taiwan.since an excellent candidate strain (m) for live virus vaccination of swine against japanese encephalitis was developed, a number of large vaccination programmes have been implemented in japan with the aim of controlling japanese encephalitis epidemics in man by reducing the population size of nonimmune swine. encouraging results have been obtained but no studies have been made on the benefits of live-virus vaccination to the industry. in order to determine the effect of vaccination upon the num ...19724340690
ecological studies on the mosquito vectors of japanese encephalitis.these studies were conducted in china (province of taiwan) to assess the populations of known and potential mosquito vectors of japanese encephalitis in a typical endemic area, and to evaluate a variety of sampling techniques, some of which were new. culex annulus was found to be the predominant vector species in the study area during the epidemic season; c. tritaeniorhynchus was never abundant, and c. fuscocephalus was rare. c. annulus and c. tritaeniorhynchus were active throughout the year, a ...19734367779
host-feeding patterns and behaviour of 4 culex species in an endemic area of japanese encephalitis.studies were made on the host-feeding patterns and behaviour of 4 culex species in china (province of taiwan) to further assess their importance as vectors of japanese encephalitis. a relatively unbiased, non-attractant technique (vacuum sweep-net) was used for collecting mosquitos resting outdoors on rural premises; blood meals from engorged specimens were identified by precipitin tests. additional information was obtained by analysing data from related studies. precipitin-test results indicate ...19734367780
seasonal infection of culex mosquitos and swine with japanese encephalitis virus.a year-round study of the infection rates of je virus in culex mosquitos was made during 1970-71 in 2 hamlets in taoyuan county, china (province of taiwan). je virus was recovered from 5 of 314 pools of c. annulus, and from 1 of 22 pools of c. tritaeniorhynchus; these recoveries occurred during a 14-day period in july 1971. none of the 288 pools of c. p. fatigans, which had been collected between october and april, was positive. in addition, sentinel swine were assessed for antibody and virus. a ...19734369158
a surveillance for japanese encephalitis (je) in pigs in southern taiwan. 19744371584
comparative studies on japanese encephalitis virus strains isolated in taiwan. i. preparation of hemagglutination and complement-fixing antigens. 19685253593
japanese encephalitis virus surveillance in taiwan. i. isolations from mosquitoes 1967-1968. 19695293625
rates of infection with japanese encephalitis virus of two culicine species of mosquito in taiwan.the role of culex annulus as a japanese-encephalitis (je) vector has been drawing increasing attention recently. in this small trial, the rate of je virus infection in c. annulus was compared with that in c. tritaeniorhynchus summorosus in the north-western coastal area of taiwan, where both species are common as je vectors. in order to increase the recovery rate of the virus, the mosquitos were artificially incubated at 26-28 degrees c for 10 days after collection. two out of 6 c. t. summorosus ...19715316743
japanese encephalitis virus in taiwan: preliminary evidence for culex annulus theob. as a vector. 19695820853
japanese encephalitis virus surveillance in the taipei area, taiwan in 1978.attempts were made to isolate japanese encephalitis virus from mosquitoes collected with three light traps operated twice a week at three sentinel pigpens in the taipei area from may to oct. 1978. a total of 6,549 mosquitoes trapped alive were processed in 283 pools. suspensions were inoculated into aedes albopictus cell cultures and into suckling mice. a total of 19 je virus isolates were made; 12 from pools of cx. tritaeniorhynchus, 6 from cx. annulus and one from cx. quinquefaciatus. sindbis ...19806107994
homologous and heterologous neutralization antibody responses after immunization with japanese encephalitis vaccine among taiwan children.because 21 immunized children (13%) among the 162 confirmed japanese encephalitis (je) cases during 1986-1991 occurred in taiwan, we collected 320 serum samples from taiwan children aged 15-31 and 27-44 months immediately before the 1st dose (n = 41) and 1-3 months after the 2nd dose (n = 78, 27 pairs), and immediately before (n = 58) and 1-3 months after the 3rd dose (n = 143, 44 pairs) to determine neutralization antibody (nt ab) against the nakayama (n) and beijing-1 (b) strains and two taiwa ...19947852952
[immunological study of japanese encephalitis virus--serological analysis of strains isolated from thailand, india, singapore and taiwan].antigenic comparison of the twenty-two japanese encephalitis (je) virus strains, which were isolated from taiwan, singapore, thailand and india between 1963 and 1984, was carried out by the hemagglutination inhibition (hi) test using the 15 monoclonal antibodies characterized by the different reactivities against nakayama-rfvl, beijing 1, kamiyama, muar or 691004 strain. of these twenty-two strains, the seventeen strains reacted with the kamiyama type-specific monoclonal antibody (kamima 6), but ...19948027601
[seroepidemiological investigation on japanese encephalitis in taiwan (january 1989-december 1991)].the hemagglutination inhibition (hi) test was used to detect sero-confirmed cases of clinically suspected japanese encephalitis. the results revealed a total of 76 sero-confirmed cases; 24, 27 and 25 cases respectively for the year 1989, 1990 and 1991. the percentages of sero-confirmed cases with respect to reported cases were 12.97%, 12.33%, 10.04% respectively. the mean percentage was 11.64%. the mean number of sero-confirmed cases in recent three years was 25, and morbidity rate per 100,000 p ...19938131659
ethnic differences in immune responses to hepatitis b vaccine.a national vaccination program against hepatitis b virus (hbv) to immunize every newborn was initiated in taiwan in 1986. a serologic survey of 1,812 fully vaccinated children residing in four aboriginal villages and four adjacent nonaboriginal han chinese rural villages was conducted in 1993. children in three of the four aboriginal villages had significantly lower titers of antibody against hepatitis b surface antigen (anti-hbs) than did children in the nonaboriginal villages. evaluation of co ...19968651234
assessment of neutralizing antibodies elicited by a vaccine (nakayama) strain of japanese encephalitis virus in taiwan.a total of 368 blood specimens were resampled from a serum collection containing 2914 blood samples which were collected by a random sampling in taiwan in 1991. the plaque reduction neutralization test was applied to evaluate the neutralizing ability to two strains of japanese encephalitis viruses, i.e. nakayama (the present vaccine strain) and je5 (a taiwan isolate). the result revealed that antibodies against je virus were present in each stratified age group. antibody positive rates were both ...19979287947
susceptibility of three laboratory strains of aedes albopictus (diptera: culicidae) to japanese encephalitis virus from taiwan.the susceptibility of 3 laboratory strains of aedes albopictus (skuse) (sanhsia [sh], yungho [yh], liyang [ly], and 1 strain of culex tritaeniorhynchus giles from northern and central taiwan were compared for susceptibility to the mq1-2 strain of japanese encephalitis (je) virus. the median infective dose (mid50) by intrathoracic inoculation was 0.23, 0.76, 1.60, and -0.03 log10 wmicld50 (50% weanling mice intracranial lethal dose) with ae. albopictus sh, yh, ly, and cx. tritaeniorhynchus, respe ...19979439133
antigenic characterization of nine wild-type taiwanese isolates of japanese encephalitis virus as compared with two vaccine strains.the antigenic properties of nine wild-type japanese encephalitis viruses isolated in taiwan during 1990 1994 were investigated by comparison with two inactivated vaccine strains (beijing-1, nakayama-nih). all of the nine taiwanese isolates were found to induce higher cytopathology in vero cells but showed similar mouse virulence as the two vaccine strains. antigenic characterization using six e protein-specific monoclonal antibodies shows two of the nine wild-type isolates (i.e. ch1949 and ch219 ...19989712514
the epidemiology of japanese encephalitis on taiwan during 1966-1997.japanese encephalitis (je) is an endemic disease in taiwan. a mass vaccination program of children against je was first implemented in 1968. along with general improvements in various aspects of living conditions over the years, the program has brought je well under control. the main characteristics of je epidemiology in taiwan in the past 3 decades are as follows. the transmission mode remains unchanged-that is, the amplification stage of the virus in pigs is followed by a human epidemic each y ...199910432061
[seroepidemiology of japanese encephalitis viral infection among 3-6 years old children from mountainous and plains townships located in the northern, central, southern and eastern taiwan].in order to evaluate the japanese encephalitis virus (jev) vaccination program in rural taiwan, we conducted a seroepidemiological survey of jev among rural children 3 to 6 years of age in taiwan. the children were selected through a systemic sampling following stratification by age of children in 4 selected aboriginal villages and 4 adjacent nonaboriginal villages. the overall vaccine coverage rate for the primary (2 doses) dose was 81.2% (1853/2281) with higher rates (87.7%-87.9%) found among ...199710592824
vector competence of culex pipiens molestus (diptera: culicidae) from taiwan for a sympatric strain of japanese encephalitis virus.laboratory strains of culex pipiens molestus forskal and culex tritaeniorhynchus giles from northern taiwan were compared for their susceptibility to the sanhsia mq1-2 (sh) strain of japanese encephalitis (je) virus isolated from taiwan. after feeding on a sweetened blood-virus mixture, viral titers in cx. p. molestus during the 14-d incubation period ranged from a minimum of 2.9 log10pfu (plaque forming units) per mosquito on day 3 after ingestion to a maximum of 4.65 log10pfu at day 8 and in c ...200011004796
genetic variation of japanese encephalitis virus in taiwan.a 280-nucleotide sequence from the capsid-premembrane (c/prem) gene region of 44 japanese encephalitis (je) virus strains isolated in taiwan from mosquitoes from 1983 to 1994, and 3 strains, (ling [1965], chang [1965], and hv1 [1958]) isolated from human brain were analyzed by direct sequencing of reverse transcription-polymerase chain reaction (rt-pcr) amplified products and compared with the corresponding sequences of reference strains. the overall sequence homology of the 47 isolates was > or ...200011220759
isolation of japanese encephalitis virus from mosquitoes collected in northern taiwan between 1995 and 1996.mosquito collections were carried out from may to october in 1995 and 1996 at yingko and sanhsia of taipei county and chunan of miaoli county. a grand total of 13,576 mosquitoes consisting of 13 species in 407 pools were processed and inoculated into aedes albopictus clone c6/36 cell cultures. one hundred thirty seven pools of these showed the presence of viral antigens in the infected c6/36 cell lysates which were identified by the indirect fluorescent antibody test using a monoclonal antibody ...199911561572
mutations in the ns3 gene and 3'-ncr of japanese encephalitis virus isolated from an unconventional ecosystem and implications for natural attenuation of the virus.the t1p1 strain of japanese encephalitis (je) virus was recently isolated from paddy-free liu-chiu islet in which natural je antibody has been prevalent. in mouse neuroblastoma-derived neuro-2a cells, t1p1 appeared significantly lower in virus productivity than another local isolate, ch1392. it implied that this new isolate possesses a characteristic viral replication pattern other than that of ch1392. t1p1 has also shown lower neurovirulence, which was reflected by a significantly higher ld(50) ...200111601924
seasonal prevalence of anti-japanese encephalitis virus antibody in pigs in different regions of taiwan.although the endemic season of japanese encephalitis lasts from may through october, sporadic cases occur in other months of the year. to appreciate the real situation of japanese encephalitis virus (jev) activity throughout the year, a survey was conducted using hemagglutination-inhibition test to detect the presence of anti-jev antibodies in pigs' sera, which were collected from 4 regions of taiwan between january 2000 and january 2001. results indicate that (1) jev-infected pigs were found th ...200211950114
diagnosis and genetic analysis of japanese encephalitis virus infected in horses.nervous disorders were found in two horses and verified as aseptic encephalitis by necropsy in the summer of 2000. to investigate agents that affected the horses, diagnostic procedures involving virus isolation, neutralization test and reverse transcription-polymerase chain reaction (rt-pcr) were performed. we intracranially inoculated litters of suckling mice with tissues suspected of containing aseptic encephalitis, including cerebrum, cerebellum, brain stem, thalamus, and cerebrospinal fluids ...200212449242
cloning and sequencing of complete cdna of japanese encephalitis virus yl strain in taiwan.we determined the complete nucleotide sequence of the yl strain of japanese encephalitis virus and its amino acid sequence was deduced. our results displayed that the genome of yl strain contained a single open reading frame of 10,296 nucleotides (nts) which was flanked by untranslated region (utr) containing 95 bases at the 5'-end and 586 bases at the 3'-end, respectively. comparison of sequences showed that the overall amino acid sequence and 3' utr of yl were similar to those of the virulent ...200312803471
induction of cross-protection against two wild-type taiwanese isolates of japanese encephalitis virus using beijing-1 strain dna vaccine.japanese encephalitis virus (jev), a mosquito-borne flavivirus, is an important human pathogen. mouse brain-derived, inactivated jev vaccines have contributed greatly to the reduction in numbers of je patients in several countries, including taiwan. however, mice immunized with the nakayama strain inactivated vaccine show lower protection against a lethal strain of beijing-1 jev than those immunized with the homologous vaccine. dna vaccine encoding the envelope (e) protein gene appears to provid ...200312922129
the pig-mosquito cycle of japanese encephalitis virus in taiwan. 196414222871
seroepidemiology study of japanese encephalitis neutralizing antibodies in southern taiwan: a comparative study between urban city and country townships.japanese encephalitis (je) occurs all over asia, especially in southeastern regions. the aim of this study was to evaluate the current je vaccination regimen in taiwan by assessing the neutralizing antibody among people of various age groups from different living environments.200314639442
potential role of armigeres subalbatus (diptera: culicidae) in the transmission of japanese encephalitis virus in the absence of rice culture on liu-chiu islet, taiwan.mosquitoes known to be involved in the transmission of japanese encephalitis virus (je) on taiwan typically develop in rice fields. however, recent serological evidence indicated that je virus was being transmitted on liu-chiu, a rice-free islet. to identify the mosquito vector in this unusual epidemiological situation, 4 mosquito species commonly found in liu-chiu were evaluated for their vector competence for a strain of je (ch1392) virus isolated from central taiwan. armigeres subalbatus (coq ...200015218913
mosquito surveys carried out on green island, orchid island, and penghu island, taiwan, in 2003.field surveys of mosquitoes were carried out on green, orchid, and penghu islands in 2003 to ascertain the status of mosquito vectors. eighteen species of mosquitoes were collected, including three species of anopheles, four species of aedes, eight species of culex, two species of armigeres, and one species of malaya. seventeen previously recorded species were not collected in this study but 11 species collected had not previously been recorded. ten newly recorded species, an. maculatus, an. tak ...200515825689
the efficacy of mouse-brain inactivated nakayama strain japanese encephalitis vaccine--results from 30 years experience in taiwan.an intensive mandatory vaccination program has been underway, combating japanese encephalitis (je) since 1968 in taiwan. long-term collection of immunization records has been developed from 1967 to 2000 in this study to retrospectively assess the efficacy of the mouse-brain inactivated nakayama je vaccine. the vaccine efficacy (ve) of completing at least two doses of the je vaccine was 96.98%. among 1 to 14-year-old children, the efficacy of completing 1, 2, and 3 doses of immunization was 85.59 ...200616314007
monitoring of japanese encephalitis virus infection in mosquitoes (diptera: culicidae) at guandu nature park, taipei, 2002-2004.japanese encephalitis virus (jev) infection in mosquitoes was monitored at guandu nature park in taipei city from september 2002 to december 2004. in total, 30,386 female mosquitoes consisting of six genera and 14 species were processed for virus in 1,229 pools by using flavivirus ns5 gene sequences detected by reverse transcription-polymerase chain reaction (pcr) and nested pcr assay. overall, 101 pools were positive, including 95, 1, 4, and 1 for culex tritaeniorhynchus giles, culex sitiens wi ...200516465752
high antibody prevalence in an unconventional ecosystem is related to circulation of a low-virulent strain of japanese encephalitis virus.liu-chiu islet, a relatively isolated ecosystem that is free of rice cultivation, has long considered free of japanese encephalitis (je). however, a new strain (t1p1) of je virus was isolated from the mosquito, armigeres subalbatus, and a rather broad distribution of neutralizing antibody has been reported on the islet, suggesting that the circulating virus could be an attenuated strain. in an assessment on 219 blood samples obtained from residents of liu-chiu islet, the positive rate of jev-spe ...200717113688
acute flaccid paralysis as an unusual presenting symptom of japanese encephalitis: a case report and review of the literature.japanese encephalitis (je) is an endemic disease in taiwan. acute je virus infection characterized by acute flaccid paralysis in an adult has never been reported in taiwan. we report a young adult man who received four doses of jev (nakayama strain) vaccination in childhood, but still developed acute je virus infection, characterized with acute flaccid paralysis.he presented with fever, headache, progressive muscle weakness, and respiratory paralysis requiring mechanical ventilator. deep tendon ...200717297587
the impact of climate on japanese encephalitis.the aim of this study was to assess the change of seasonal pattern of japanese encephalitis (je) cases in the post-vaccination period and to elucidate whether the lagged climate variables (precipitation and temperature) were associated with occurrence of je after adjustment for seasonal pattern, time trend, geographic areas, pig density, vaccination coverage rate for humans, and time dependence of time-series numbers of je cases. a total of 287 confirmed je cases between 1991 and 2005 were colle ...200817767793
clinical manifestations of japanese encephalitis in southern taiwan.japanese encephalitis virus infection is a sporadic infectious disease in taiwan. despite progress in laboratory examinations and imaging studies, diagnosis of japanese encephalitis remains underestimated. this study was conducted to identify clinical symptoms and laboratory findings that may assist in early identification of this disease.200919949752
molecular epidemiology of japanese encephalitis virus, taiwan. 201020409392
screening of mosquitoes using sybr green i-based real-time rt-pcr with group-specific primers for detection of flaviviruses and alphaviruses in taiwan.surveillance for infectious agents carried by mosquitoes is important for predicting the risk of vector-borne infectious diseases. in this study, a method was established to mass-screen mosquitoes for viral infections. the assay detected the viral load of 4 dengue virus (denv) serotypes (denv-1, denv-2, denv-3, and denv-4), the japanese encephalitis virus (jev), the sindbis virus and the chikungunya virus at 1pfu/ml (determined by real-time rt-pcr) in 36.64-43.45 cycles. this method was applied ...201020471427
japanese encephalitis virus genotype replacement, taiwan, 2009-2010.genotype i of japanese encephalitis virus first appeared in taiwan in 2008. phylogenetic analysis of 37 viruses from pig farms in 2009-2010 classified these viruses into 2 unique subclusters of genotype i viruses and suggested multiple introductions and swift replacement of genotype iii by genotype i virus in taiwan.201122172307
clinical evolution of japanese encephalitis. 20154365023
the incidence of japanese encephalitis in taiwan--a population-based study.a mass japanese encephalitis (je) vaccination program targeting children was launched in taiwan in 1968, and the number of pediatric je cases substantially decreased thereafter. the aim of this study was to elucidate the long-term trend of je incidence, and to investigate the age-specific seroprevalence of je-neutralizing antibodies.201425058573
effects of extreme precipitation to the distribution of infectious diseases in taiwan, 1994-2008.the incidence of extreme precipitation has increased with the exacerbation of worldwide climate disruption. we hypothesize an association between precipitation and the distribution patterns that would affect the endemic burden of 8 infectious diseases in taiwan, including water- and vector-borne infectious diseases. a database integrating daily precipitation and temperature, along with the infectious disease case registry for all 352 townships in the main island of taiwan was analysed for the pe ...201222737206
molecular epidemiology of japanese encephalitis virus in mosquitoes in taiwan during 2005-2012.japanese encephalitis (je) is a mosquito-borne zoonotic disease caused by the japanese encephalitis virus (jev). pigs and water birds are the main amplifying and maintenance hosts of the virus. in this study, we conducted a jev survey in mosquitoes captured in pig farms and water bird wetland habitats in taiwan during 2005 to 2012. a total of 102,633 mosquitoes were collected. culex tritaeniorhynchus was the most common mosquito species found in the pig farms and wetlands. among the 26 mosquito ...201425275652
re-assess vector indices threshold as an early warning tool for predicting dengue epidemic in a dengue non-endemic country.despite dengue dynamics being driven by complex interactions between human hosts, mosquito vectors and viruses that are influenced by climate factors, an operational model that will enable health authorities to anticipate the outbreak risk in a dengue non-endemic area has not been developed. the objectives of this study were to evaluate the temporal relationship between meteorological variables, entomological surveillance indices and confirmed dengue cases; and to establish the threshold for ent ...201526366874
partially neutralizing potency against emerging genotype i virus among children received formalin-inactivated japanese encephalitis virus vaccine.genotype i (gi) japanese encephalitis virus (jev) that replaced giii virus has become the dominant circulating virus in asia. currently, all registered live and inactivated jev vaccines are derived from genotype iii viruses. in taiwan, the compulsory jev vaccination policy recommends that children receives four doses of formalin-inactivated nakayama (giii) jev vaccine.201223029592
severe dengue fever outbreak in taiwan.dengue fever (df) is a vector-borne disease caused by dengue viruses (denvs). epidemic dengue occurs intermittently in taiwan. in 2014, taiwan experienced its largest df outbreak. there were 15,732 df cases reported. there were a total of 136 dengue hemorrhagic fever (dhf) cases, of which 20 resulted in death. most df cases were reported in southern taiwan. a total of 15,043 (96%) cases were from kaohsiung, a modern city in southern taiwan. this report reviews df epidemics in taiwan during 2005- ...201526572871
reduced neutralizing antibody titer against genotype i virus in swine immunized with a live-attenuated genotype iii japanese encephalitis virus vaccine.a shift in prevalence from japanese encephalitis virus (jev) genotype iii (giii) to gi virus has been observed in several asian countries. genotype i virus was first detected in taiwan in 2008, and became the dominant jev island-wide within a year. we conducted a serosurvey using swine serum specimens from multiple counties in taiwan following the transmission season in 2009 and results showed 67-100% of jev seropositive swine showed evidence of gi virus infection. the envelope (e) protein is a ...201323415032
the pig-mosquito cycle of japanese encephalitis virus in taiwan. res rep mr005.09-1406.2.4. 196424547281
current outlook of infectious diseases in taiwan.the "emerging" infectious diseases have received global attention. taiwan is a country which is going through the process of becoming "developed" from being "developing". if we compare five leading causes of death in 1952 and in 1993, three were infectious diseases in 1952 and there was none in 1993. and yet today, infectious diseases remain a major problem in this country as well in every country in the world, whether developing or developed. some of the problems taiwan faces are old problems w ...199810596983
epidemiological features of japanese encephalitis in taiwan from 2000 to 2014.the incidence of japanese encephalitis (je) decreased sharply after the national vaccination program was implemented in taiwan in 1968. however, cases of je still occur. the purpose of this study was to assess the epidemiology and vaccination policy for je in taiwan. we analyzed the data on je cases reported to the taiwan centers for disease control (taiwan cdc) between 2000 and 2014. during the 15-year study period, a total of 4,474 cases were reported to the taiwan cdc. of these, 379 (8.5%) we ...201727821699
concomitant administration of live attenuated japanese encephalitis chimeric virus vaccine (je-cv) and measles, mumps, rubella (mmr) vaccine: randomized study in toddlers in taiwan.japanese encephalitis (je) is the most important cause of viral encephalitis in asia.201424631095
japanese encephalitis vaccine: an orphan product in need of adoption. 19882827028
[control of japanese encephalitis in free china]. 1976187743
japanese encephalitis surveillance in china (province of taiwan) during 1968-1971. ii. age-secific incidence in connection with japanese encephalitis vaccination program.a baseline age/morbidity pattern for japanese encephalitis (je) epidemic in china (province of taiwan) in the 1960s was sought in je surveillance. the pattern is characterized by: (1) high incidence in age groups 2-4 years, (2) moderately high incidence in age groups 5-7 years, (3) negligible incidence in children under 1 year of age as well as in adults, and (4) the variability of relative height of peak incidence co-incident with the je-epidemic size in situ. concurrently with surveillance, a ...2004180320
preliminary studies on the control of japanese encephalitis vectors in taiwan by chemical means. 19744140889
comparative epidemiological features of japanese encephalitis in the republic of korea, china (taiwan) and japan.the epidemiology of japanese encephalitis in the republic of korea from 1949 to 1966 is described and comparisons are made with the situations in japan and china (taiwan). some similarities and some differences are noted. recent epidemics in korea coincided with those in southern japan but the annual fluctuations were more distinct in korea. the disease mainly affected children in korea and, in contrast to the situation in japan, persons in the older age-groups were rarely affected. the authors ...19694308334
japanese encephalitis in taiwan: a review of recent studies. 196414153415
epidemiology of japanese encephalitis (je) on taiwan in 1960. 196114449525
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