| molecular epidemiology of corynebacterium diphtheriae from northwestern russia and surrounding countries studied by using ribotyping and pulsed-field gel electrophoresis. | a selection of 100 corynebacterium diphtheriae isolates from asymptomatic carriers and clinical cases from five regions in northwestern russia were examined. six additional isolates from patients in finland and estonia with epidemiological links to russia were also examined. all isolates were characterized by biotyping, toxigenicity testing, ribotyping, and pulsed-field gel electrophoresis (pfge). hybridization of genomic dna digested with bsteii revealed five ribotype patterns among the biotype ... | 1995 | 7615709 |
| [susceptibility of corynebacteria isolated in st petersburg to antibacterial drugs]. | susceptibility of 150 corynebacterium isolates (91 strains of c.pseudodiphtheriticum and 59 strains of the anf group corynebacteria) to 21 antibacterial drugs was determined by the method of serial dilutions in a solid medium. it was shown that the mic of the drugs for the diphtheroids was within the ranges of < 0.015 to > 32.0 micrograms/ml. 66 per cent of the corynebacterium strains circulating in st. petersburg was resistant at least to 1 antibacterial drug. the corynebacterium isolates with ... | 1997 | 9480648 |
| [sensitivity of corynebacterium diphtheriae isolated in saint-petersburg to antibacterial drugs]. | one hundred and thirty strains of corynebacterium diphtheriae isolated in st. petersburg (42 toxigenic and 88 nontoxigenic) were tested with the method of serial dilutions in solid media for their susceptibility to 20 antibacterial drugs. the mics of the drugs for the isolates ranged from < or = 0.015 to > or = 32.0 micrograms/ml. 13 per cent of the isolates was resistant at least to one antibacterial drug. the isolates resistant to erythromycin (11.5 per cent), lincomycin (11.5 per cent) and tr ... | 1999 | 10483500 |
| efficient discrimination within a corynebacterium diphtheriae epidemic clonal group by a novel macroarray-based method. | a large diphtheria epidemic in the 1990s in russia and neighboring countries was caused by a clonal group of closely related corynebacterium diphtheriae strains (ribotypes sankt-peterburg and rossija). in the recently published complete genome sequence of c. diphtheriae strain nctc13129, representative of the epidemic clone (a. m. cerdeno-tarraga et al., nucleic acids res. 31:6516-6523, 2003), we identified in silico two direct repeat (dr) loci 39 kb downstream and 180 kb upstream of the oric re ... | 2005 | 15814981 |
| corynebacterium diphtheriae spoligotyping based on combined use of two crispr loci. | a large diphtheria epidemic in the 1990s in russia and neighboring countries underlined the importance of permanent surveillance of the circulating and emerging clones of corynebacterium diphtheriae, and hence there is a need for highly discriminatory, simple and portable typing methods. in the complete genome sequence of c. diphtheriae strain nctc13129, we previously identified in silico two clustered, regularly interspaced short palindromic repeat (crispr) loci, and developed a macroarray-base ... | 2007 | 17431853 |
| [polymorphism of tox and dtxr genes in circulating strains of corynebacterium diphtheriae]. | polymorphism of tox and dtxr genes responsible for diphtheria toxin synthesis was revealed. seven point mutations in tox gene were detected; study of their combinations allowed to determine 10 allelic variants of the tox gene in c. diphtheriae strains. majority of mutations did not lead to changes in substitutions in amino acid sequence of diphtheria toxin. in tox gene from 2 strains of mitis biovar, ribotype "otchakov" isolated in saint-petersburg, mutation in position 1252 (g --> c), which cor ... | 2009 | 19340963 |
| [features of biologic characteristics of corynebacterium diphtheriae circulating in postepidemic period]. | to study main biologic characteristics of c. diphtheriae strains circulating in north-west region of russia for the last 15 years. | 2009 | 19623714 |