| fungal empyema thoracis: an emerging clinical entity. | to analyze the clinical spectra, pathogenesis, treatment, outcome, and prognostic factors of fungal empyema thoracis. | 2000 | 10858401 |
| community-onset candidemia at a university hospital, 1995-2005. | although not all candidemias are hospital-acquired, data on clinical epidemiology for the community-onset candidemia are limited. this retrospective study was conducted to describe predisposing factors and outcomes of community-onset candidemias. | 2007 | 17712471 |
| the distribution of species and susceptibility of amphotericin b and fluconazole of yeast pathogens isolated from sterile sites in taiwan. | to study the demographic changes of yeasts causing invasive infections in taiwan, especially with respect to species distribution and antifungal susceptibility, we analyzed isolates obtained from four sterile sites of patients in 19 hospitals in 2002 (155 strains) and again from the same hospitals in 2006 (208 strains). blood was the most common source of the yeasts, accounting for 73.8% of the total isolates, followed by ascites (21.5%), cerebrospinal fluid (3%), and synovia (1.7%). candida alb ... | 2010 | 20141372 |
| changing epidemiology of nosocomial bloodstream infections in 11 teaching hospitals in taiwan between 1993 and 2006. | healthcare-associated infections, formerly known as nosocomial infections, are one of the most important issues in current practice. understanding trends in overall infection rates, as well as their incidence and proportion among different causative organisms, can help us to better define our infection control methods and therapy goals. to understand the changing epidemiology of nosocomial bloodstream infections (bsi) in taiwan, we retrospectively collected nosocomial infection data from 11 hosp ... | 2010 | 21075709 |
| invasive candidiasis: an overview from taiwan. | invasive candidiasis has emerged as an important nosocomial infection, especially in critically ill patients. we review the epidemiology of invasive candidiasis with an emphasis on data from taiwan. an increasing incidence of candidemia became apparent from 1980 to the end of the 1990s, followed by relative stability. crude mortality rates of patients with candidemia were in the range of 35% to 60%. candida albicans remains the predominant cause of invasive candidiasis in taiwan and accounts for ... | 2009 | 19515624 |
| candida glabrata fungaemia in a tertiary centre in taiwan: antifungal susceptibility and outcomes. | the proportion of non-albicans candidaemia has increased during recent decades, especially candida glabrata. we evaluated the antifungal susceptibility, clinical features and outcome of c. glabrata fungaemia treated in a tertiary centre in taiwan. all episodes of c. glabrata fungaemia during 1999-2005 were identified from microbiology laboratory records and all c. glabrata isolates were subjected to antifungal susceptibility testing by the broth microdilution method. a total of 177 episodes of c ... | 2009 | 19361960 |
| susceptibilities to amphotericin b and fluconazole of candida species in taiwan surveillance of antimicrobial resistance of yeasts 2006. | susceptibilities to amphotericin b and fluconazole of 964 candida isolates collected in taiwan surveillance of antimicrobial resistance of yeasts in 2006 were determined. there were 419 (43.5%) candida albicans, 246 (25.5%) candida tropicalis, 211 (21.9%) candida glabrata, 62 (6.4%) candida parapsilosis, 14 (1.5%) candida krusei, and 12 (1.2%) others. interestingly, 16 of the 17 amphotericin b-resistant isolates were non-albicans candida species. the resistant rate to amphotericin b has decrease ... | 2008 | 18304773 |
| the trend of susceptibilities to amphotericin b and fluconazole of candida species from 1999 to 2002 in taiwan. | candida species have various degrees of susceptibility to common antifungal drugs. the extent of resistance to amphotericin b and fluconazole of candida glabrata isolates causing candidemia has been reported. active surveillance may help us to monitor the trend of susceptibility to antifungal drugs and to determine if there is an emerging co-resistance to both drugs of candida species, specifically, of c. glabrata in taiwan. | 2005 | 16266438 |
| genotyping analysis of colonizing candidal isolates from very-low-birthweight infants in a neonatal intensive care unit. | to analyse the relatedness of colonizing candidal isolates from very-low-birthweight infants hospitalized in a neonatal intensive care unit (nicu), we prospectively collected 86 candidal isolates from 20 infants, including 67 isolates of candida albicans from 15 infants, 17 isolates of candida parapsilosis from five infants and two isolates of candida glabrata from one infant, who also had c. albicans colonization, over a one-year period. all 86 isolates were genotyped by infrequent-restriction- ... | 2004 | 15501334 |
| species distribution and fluconazole susceptibility of candida clinical isolates in a medical center in 2002. | fluconazole disk-diffusion susceptibility was evaluated in 230 blood isolates and 344 non-blood clinical isolates of candida spp. collected in 2002 at national taiwan university hospital. up to 93.5% of blood isolates were susceptible to fluconazole, 3% were susceptible dose-dependent, and 3.5% were resistant. the minimum inhibitory concentrations at which 50% of tested isolates were inhibited (mic50) of fluconazole against candida blood isolates were highest for candida glabrata (5 microg/ml), ... | 2004 | 15340652 |
| in vitro activity of voriconazole against candida species isolated in taiwan. | the activity of voriconazole was determined against 285 candida species consisting of 53 resistant isolates, 43 susceptible-dose dependent and 189 isolates susceptible to fluconazole. the mic(50) and mic(90) to fluconazole were 8 and 64 mg/l, respectively. the range of minimum inhibitory concentrations (mics) to voriconazole was from 0.0325 to 2 mg/l and the mic(50) and mic(90) were 0.125 and 0.5 mg/l, respectively. only 3 of 285 tested isolates had mics to voriconazole equal to 2 mg/l. a total ... | 2004 | 15325436 |
| fluconazole resistance rate of candida species from different regions and hospital types in taiwan. | from april 15 to june 15, 1999, 581 clinical candida isolates from 19 hospitals in taiwan were collected and susceptibilities to fluconazole of these isolates were determined by a broth microdilution method. a total of 42 (7.2%) isolates were resistant to fluconazole. isolates from medical centers had a higher resistance rate to fluconazole than those from regional hospitals (10.7% vs 4.9%). candida species isolated from different regions had different degrees of susceptibility to fluconazole. a ... | 2003 | 14582563 |
| stable susceptibility of candida blood isolates to fluconazole despite increasing use during the past 10 years. | the prevalence of drug-resistant bacterial pathogens is very high in taiwan. accordingly, there was great concern that the introduction of fluconazole would result in rapid emergence of drug-resistant yeasts. thus, we recommended in 1991 that fluconazole be used for treatment only. to explore the impact of this policy fluconazole susceptibility of candida species blood culture isolates and outcome of patients with nosocomial candidaemia were monitored prospectively at national taiwan university ... | 2003 | 12775680 |
| secular trends in the epidemiology of nosocomial fungal infections at a teaching hospital in taiwan, 1981 to 1993. | to describe the incidence and patterns of nosocomial fungal infection in a large teaching hospital in taiwan. | 1997 | 9154483 |
| epidemiology and antifungal susceptibility of candidemia isolates of non-albicans candida species from cancer patients. | candidemia is a growing concern worldwide, and its species distribution has shifted toward non-albicans candida in recent decades, especially in patients with malignancy. this study aimed to update the epidemiology and antifungal susceptibility of non-albicans candidemia isolates from the cancer patients. adult cancer patients with non-albicans candidemia were recruited, and clinical data were retrospectively collected from five medical centers in taiwan from 1 july 2011 to 30 june 2014. in vitr ... | 2017 | 29018251 |
| association between incidence of candidaemia and consumption of antifungal agents at a medical centre in taiwan. | this study investigated the correlations between consumption of antifungal agents and species distribution in candidaemia. the incidence of patients with community-acquired candidaemia (cac) (per 1000 admissions) and healthcare-associated candidaemia (hcac) (per 1000 admissions) as well as data on annual consumption [defined daily doses (ddd)/1000 patient-days] of various antifungal agents at a medical centre in taiwan from 2000 to 2010 were evaluated. a total of 2682 episodes of candidaemia wer ... | 2012 | 22819796 |
| clinical characteristics of candidaemia in adults with haematological malignancy, and antimicrobial susceptibilities of the isolates at a medical centre in taiwan, 2001-2010. | during the period 2001-2010, a total of 154 episodes of candidaemia were noted in 111 of 2574 patients with haematological malignancies at the national taiwan university hospital (taipei, taiwan). patients with acute lymphoblastic leukaemia had a significantly higher rate of candidaemia than patients with other haematological malignancies (odds ratio=2.69; p<0.001). candida tropicalis was the most common candida species (n=51; 46%), followed by candida albicans (n=35; 32%), candida parapsilosis ... | 2012 | 23006521 |
| an emerging issue of mixed yeast cultures. | different yeast species have different susceptibilities to commonly prescribed antifungal drugs. thus, it is important to accurately determine the species of pathogenic yeasts, especially when more than one species are in a specimen. | 2014 | 23523053 |
| changing epidemiology of candidemia in a medical center in middle taiwan. | candidemia remains a major cause of morbidity and mortality in the health care setting, and the epidemiology of candida infection is changing. | 2015 | 24113067 |
| yeast oropharyngeal colonization in human immunodeficiency virus-infected patients in central taiwan. | a prospective, cross-sectional study was conducted at a medical center in central taiwan to understand the prevalence, associated factors, and microbiologic features for oropharyngeal yeast colonization in human immunodeficiency virus-infected outpatients. oral yeast colonization was detected in 127 (45 %) patients, including 21 (16.5 %) colonized by more than one species. of the 154 isolates, candida albicans was the most common species (114, 74 %), followed by candida dubliniensis (10, 6.5 %), ... | 2014 | 24804977 |
| antifungal susceptibility of candida species isolated from patients with candidemia in southern taiwan, 2007-2012: impact of new antifungal breakpoints. | the clinical and laboratory standard institute (clsi) revised the clinical breakpoints (cbps) for the azoles and echinocandins against candida species in 2012. we aimed to report the epidemiology of candidemia and antifungal susceptibility of candida species and evaluate the impact of new cbps on antifungal susceptibility in our region. all blood isolates of candida species were obtained from 2007 to 2012. the minimum inhibitory concentrations of fluconazole, voriconazole, echinocandins and fluc ... | 2017 | 27621210 |
| time to blood culture positivity of different candida species causing fungemia. | this study investigated the time to positivity (ttp) of different species of candida causing bloodstream infection and whether ttp can help differentiate fluconazole-resistant candida glabrata and c. krusei from other candida species. we prospectively conducted this study at the national taiwan university hospital, a 2500-bed tertiary care medical center in northern taiwan. patients with candidemia were identified by central laboratory personnel from july 2010 to march 2011. ttp in each patient ... | 2012 | 22245787 |
| human pathogenic fungi in china-emerging trends from ongoing national survey for 1986, 1996, and 2006. | this epidemiological survey was a retrospective study on three nodes during the past three decades on fungal infections representing the china, including taiwan. owing to rare publications reporting on dynamic epidemiological trends in the pathogen epidemiology in china, we surveyed the isolation rates and pathogenic fungi from 8 representative districts in china using uniform identification with uniform methodology. the pathogenic fungi isolation rates and species obtained from 1986 (n = 9,096) ... | 2011 | 21509517 |
| characterization of candida species from different populations in taiwan. | the opportunistic candida species existing as part of commensal microbiota in humans are usually the etiological agents causing infections. we investigated whether isolates collected from different age groups, hospital units, and sources have distinct characteristics. a total of 913 isolates comprising 395 candida albicans, 230 candida tropicalis, 202 candida glabrata, 62 candida parapsilosis, 13 candida krusei, and 11 of other six species were analyzed. urine was the most common source (41.2%), ... | 2011 | 21369746 |