Publications

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burden of invasive disease caused by haemophilus influenzae type b in bamako, mali: impetus for routine infant immunization with conjugate vaccine.population-based, bacteriologically confirmed disease burden data aid decision makers in african countries pondering whether to introduce haemophilus influenzae type b (hib) immunization for infants.200515933564
naturally acquired and conjugate vaccine-induced antibody to haemophilus influenzae type b (hib) polysaccharide in malian children: serological assessment of the hib immunization program in mali.haemophilus influenzae type b (hib) conjugate vaccine for infants (6, 10, and 14 weeks of age) was introduced into the malian expanded program on immunization in july 2005, to diminish invasive hib disease in young children. antibodies to hib capsular polysaccharide (prp) were measured in infants and toddlers from an area already served by the hib immunization program (bamako) and in unimmunized children of the same age in a district (kangaba) where hib immunization had not yet begun. among vacc ...201222665612
invasive nontyphoidal salmonella infections among children in mali, 2002-2014: microbiological and epidemiologic features guide vaccine development.in 2002, following establishment of a clinical microbiology laboratory in the government hospital that admits children with severe illnesses in bamako, mali, surveillance to identify pathogens causing invasive bacterial infections (septicemia, bacteremia, meningitis, etc) was initiated.201526449949
haemophilus influenzae type b conjugate vaccine introduction in mali: impact on disease burden and serologic correlate of protection.in bamako, mali, where surveillance revealed a high incidence of haemophilus influenzae type b (hib) invasive disease, hib conjugate vaccine was introduced into the expanded program on immunization and the impact assessed. annual confirmed hib hospitalizations for infants 0-11 months of age fell from 175/10(5) to 44/10(5) (p < 0.001); among infants 6-7 months of age hib hospitalizations fell from 377/10(5) to 69/10(5), (82% decrease, p < 0.001). invasive streptococcus pneumoniae hospitalizations ...200919478272
[haemophilus influenzae b among bacterial meningitis in bamako (2002-2004)].in mali little study exist on the meningitis with haemophilus influenzae b (hib). this weak data availability on hib meningitis, didn't permit to introduce the immunization against this pathology in the expanded program immunization (epi) of mali. the present survey aims to improve the availability of the data on hib meningitis and to advocate for the introduction of immunization against hib in epi in mali. the survey consisted to the exploitation of spinal fluid examination data for the suspect ...200819434968
the causes of hospital admission and death among children in bamako, mali.the health burden and mortality caused by infections during childhood remain large in sub-saharan africa. we performed a review of the causes of hospitalization and death among children admitted to a pediatric teaching hospital in bamako, mali. medical records of children admitted throughout 2000 were systematically sampled and abstracted for demographics, diagnosis, hospital course, and disposition. a sample of 1644 charts, from 5001 admitted children, were abstracted. the median age was 8 mont ...200415233192
[bacteriological aspects of purulent meningitis in bamako district. apropos of 1,541 bacterial strains collected from 1979 to 1991].this study is about bacteriological aspects of purulent meningitis in bamako area upon 1,541 strains collected from 1979 to 1991. it showed that n. meningitidis, s. pneumoniae and h. influenzae b are responsible. in general, n. meningitidis is the most frequent, but this depends on years and months. since 1988, n. meningitidis serogroup c has supplanted serogroup a. n. meningitidis is predominant between 7 to 30 years. s. pneumoniae between 1-28 days and 31 to 68 years, h. influenzae between 1 m ...19938353475
modeling the potential for vaccination to diminish the burden of invasive non-typhoidal salmonella disease in young children in mali, west africa.in sub-saharan africa, systematic surveillance of young children with suspected invasive bacterial disease (e.g., septicemia, meningitis) has revealed non-typhoidal salmonella (nts) to be a major pathogen exhibiting high case fatality (~20%). where infant vaccination against haemophilus influenzae type b (hib) and streptococcus pneumoniae has been introduced to prevent invasive disease caused by these pathogens, as in bamako, mali, their burden has decreased markedly. in parallel, nts has become ...201728182657
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