Publications

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patterns of plasmodium vivax recurrence in a high-incidence coastal area of el salvador, c. a.during field studies carried out in 1971, 1972 and 1973 in a highly malarious coastal area of el salvador, it was possible to collect information on the patterns of plasmodium vivax parasite occurrence in a large number of infected individuals. in most of the persons who had experienced a malaria attack during the high transmission period in june, july, august and september, renewed activity occurred 5 to 8 months later, during the low transmission season the next year. subsequent activity in th ...1975239603
malaria field studies in a high-incidence coastal area of el salvador, c.a.a three-year investigation was made of the incidence patterns and characteristics of malaria in a small high-incidence coastal area of el salvador with a resident population of about 6,000 persons and a migrant population of 3,000 to 4,000 others. it found a significant increase in the incidence of plasmodium falciparum cases during the three-year period, combined with relative stability in the annual number of plasmodium vivax cases. a close correlation was observed between the seasonal occuren ...1977328096
salvador ii strain of plasmodium vivax in aotus monkeys and mosquitoes for transmission-blocking vaccine trials.infections with the salvador ii strain of plasmodium vivax in aotus lemurinus griseimambra monkeys were fed upon by anopheles freeborni mosquitoes. periods of mosquito infectivity were determined to establish a model system for the testing of transmission-blocking vaccines. the highest levels of mosquito infection were associated with the ascending asexual parasitemia after reaching 1,000/microl, and before the peak asexual parasite count. sporozoite-induced infections were more infectious than ...19989684622
studies on the santa lucia (el salvador) strain of plasmodium falciparum in aotus trivirgatus monkeys.the santa lucia strain of plasmodium falciparum was isolated from el salvador, central america, and established in aotus trivirgatus monkeys. transmission from monkey to monkey via the bites of infected anopheles freeborni, a. maculatus, and a, albimanus mosquitoes was obtained in 20 of 27 attempts. prepatent periods in the monkeys ranged from 17 to 46 days with a mean of 24.3 days. parasitemias and mortality were higher following sporozoite inoculation into animals which had been previously inf ...1977403272
the seroepidemiology of malaria in middle america. iv. passage of malaria antibodies from mothers to infants.in an area of el salvador moderately endemic for malaria, use of the indirect fluorescent antibody test (ifa) showed that 44% of the infants born to mothers who had ifa responses to plasmodium vivax of 1:20 or higher during the latter part of their pregnancy had positive ifa responses of 1:10 or higher to this antigen. no serum from an infant was positive in the absence of some level of malarial response in the mother.1977339753
polymorphism at the merozoite surface protein-3alpha locus of plasmodium vivax: global and local diversity.allelic diversity at the plasmodium vivax merozoite surface protein-3alpha (pvmsp-3alpha) locus was investigated using a combined polymerase chain reaction/restriction fragment length polymorphism (pcr/rflp) protocol. symptomatic patient isolates from global geographic origins showed a high level of polymorphism at the nucleotide level. these samples were used to validate the sensitivity, specificity, and reproducibility of the pcr/rflp method. it was then used to investigate pvmsp3alpha diversi ...199910548283
rupture of the spleen in a central american immigrant. 19968595993
further studies on the sporozoite transmission of the salvador i strain of plasmodium vivax.different species of saimiri and aotus monkeys were inoculated with sporozoites of the salvador i strain of plasmodium vivax. of 58 saimiri inoculated, 45 developed parasitemia (4 following bites and 41 following intravenous inoculation). prepatent periods ranged from 10 to 63 days. twelve of 19 monkeys inoculated with sporozoites that had been stored frozen developed patent parasitemia after 16-53 days. of 41 aotus monkeys inoculated, only 10 (2 via bites and 8 via intravenous inoculation) deve ...19948064516
seroepidemiological studies of malaria in pregnant women and newborns from coastal el salvador.a cohort of 113 women and their newborns from the coastal area of el salvador were studied longitudinally to estimate malaria incidence and indirect fluorescent antibody (ifa) response to malaria infection. the district in which the study was conducted had an estimated annual parasite index of 600/1,000 inhabitants, and all malaria infections were treated immediately with a 4-aminoquinoline. in the third trimester of pregnancy, the ifa response to plasmodium falciparum was significantly depresse ...19806989276
the seroepidemiology of malaria in middle america. v. antibody responses in an indicator population from an endemic area with attack phase antimalaria activities.serologic assessment was carried out in a sample of the population living in an area endemic for malaria in which control measures were being applied. the study area was in el salvador, central america, and antimalarial activities consisted of the residual application of the pesticide, propoxur, and drug distribution through a combination of active and passive case detection. indirect fluorescent antibody (ifa) responses to plasmodium vivax and p. falciparum antigens were determined on four occa ...19836359903
central america malaria research station in san salvador. 19724564959
natural infections of anopheles albimanus with plasmodium in a small malaria focus.entomologic surveys conducted in a small village in an area of known high malaria transmission in el salvador yielded a high rate of infection in anopheles albimanus collected inside houses in which cases of malaria had occurred. of 324 specimens dissected, 12 were found to harbor sporozoites or oocysts. this is in contrast to prior reports of extremely low infection rates in collections of this species from malarious areas, and suggests that under some circumstances a. albimanus does meet the c ...19751098498
the prevalence and relationships of malaria, anemia, and malnutrition in a coastal area of el salvador.to study the relationships between malaria, anemia and malnutrition, 853 school-age children from a high malaria incidence area and an adjacent low incidence area were surveyed in september 1972. for the high incidence area the malaria slide positivity rate was 3.5%, spleen rate 7.6% and malaria (indirect fluorescent antibody) serology positivity 24.7%. contrasted to this, no positive slides, only 3 palpable spleens and a 3.4% serology positivity rate were found for the low incidence area. twent ...19751091165
the seroepidemiology of malaria in middle america. iii. serologic assessment of localized plasmodium falciparum epidemics.epidemiologic studies were done in two localities, one in panama and one in el salvador, where outbreaks of plasmodium falciparum malaria occurred. the indirect fluorescent antibody (ifa) method was helpful in defining the intensity of the outbreaks, the species of parasite involved, and, through parallel surveys of adjacent localities, the localized character of outbreaks. in escobal, panama 71 (34%) of 211 persons examined were ifa-positive for p. falciparum, although only 1 positive blood fil ...1976769573
studies on human malaria in aotus monkeys. i. sporozoite transmission of plasmodium vivax from el salvador. 19734198646
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