| dynamics of malaria parasitaemia associated with febrile illness in children from a rural area of madang, papua new guinea. | active community and self-reporting surveillance techniques have been used to describe the dynamics of febrile illness and associated malaria infection in children aged 2 to 15 years from a rural area of madang province, papua new guinea (png). both history of fever and fever in association with parasitaemia appeared to be reliable indicators of malaria morbidity in this endemic area. parasite density was observed to be a major determinant of mild malarial disease at both the population level an ... | 1994 | 8036670 |
| human malaria transmission studies in the anopheles punctulatus complex in papua new guinea: sporozoite rates, inoculation rates, and sporozoite densities. | malaria sporozoite rates and inoculation rates were measured over periods up to 25 months in the different anopheline species biting humans in 13 villages in madang province, papua new guinea. analysis of three members of the anopheles punctulatus complex, 68,458 an. farauti, 36,779 an. koliensis, and 11,667 an. punctulatus caught in landing catches was made using monoclonal antibody based elisas to detect sporozoites of plasmodium falciparum and p. vivax. sporozoite rates ranged from 0%-5.5% in ... | 1988 | 3044151 |
| southeast asian ovalocytosis is associated with increased expression of duffy antigen receptor for chemokines (darc). | the duffy antigen receptor for chemokines (darc or fy glycoprotein) carries antigens that are important in blood transfusion and is the main receptor used by plasmodium vivax to invade reticulocytes. southeast asian ovalocytosis (sao) results from an alteration in rbc membrane protein band 3 and is thought to mitigate susceptibility to falciparum malaria. expression of some rbc antigens is suppressed by sao, and we hypothesized that sao may also reduce fy expression, potentiallyleading to reduce ... | 2009 | 19927622 |
| high genetic diversity of plasmodium vivax on the north coast of papua new guinea. | despite having the highest plasmodium vivax burden in the world, molecular epidemiological data from papua new guinea (png) for this parasite remain limited. to investigate the molecular epidemiology of p. vivax in png, 574 isolates collected from four catchment sites in east sepik (n = 1) and madang (n = 3) provinces were genotyped using the markers ms16 and msp1f3. genetic diversity and prevalence of p. vivax was determined for all sites. despite a p. vivax infection prevalence in the east sep ... | 2013 | 23690553 |
| association between hla type and antibody response to malaria sporozoite and gametocyte epitopes is not evident in immune papua new guineans. | hla-a,b,c and dr types were determined for 46 adults living in the madang area of papua new guinea. sera from these individuals were tested by elisa for antibodies against: (i) sonicated schizont extract of plasmodium falciparum; (ii) circumsporozoite repeat regions of p. falciparum and p. vivax; and (iii) epitopes on the 230 and 48/45 kd gametocyte antigens of p. falciparum. all sera were from highly immune individuals and reacted strongly to the schizont antigen. the proportions responding to ... | 1989 | 2482146 |
| small-area variations in the epidemiology of malaria in madang province. | | 1986 | 3529703 |
| age- and species-specific duration of infection in asymptomatic malaria infections in papua new guinea. | the burden and duration of asymptomatic malaria infections were measured in residents of the malaria endemic village of gonoa, madang province, papua new guinea. plasmodium falciparum, p. vivax and p. malariae infections in people aged 4 years to adulthood were compared. frequent sampling at 3-day intervals for up to 61 days allowed assessment of individual episodes of infection. statistical assessment of p. falciparum detection revealed a periodicity consistent with synchronous replication of t ... | 2000 | 11085245 |
| low efficacy of amodiaquine or chloroquine plus sulfadoxine-pyrimethamine against plasmodium falciparum and p. vivax malaria in papua new guinea. | because of increasing resistance to 4-aminoquinolines in papua new guinea, combination therapy of amodiaquine (aq) or chloroquine (cq) plus sulfadoxine-pyrimethamine (sp) was introduced as first-line treatment against uncomplicated malaria in 2000. the purpose of this study was to monitor in vivo efficacy of the current standard combination therapy against plasmodium falciparum and p. vivax malaria. studies were conducted between 2003 and 2005 in the simbu, east sepik, and madang provinces in pa ... | 2007 | 17984359 |
| chemoprophylaxis against malaria in papua new guinea: a trial of amodiaquine and a combination of dapsone and pyrimethamine. | a placebo-controlled chemoprophylaxis trial was carried out in 1980 in 318 semi-immune school children in the madang area of papua new guinea, where there was a high prevalence of strains of plasmodium falciparum resistant to 4-aminoquinolines. since prophylaxis with amodiaquine at 5 mg/kg weekly had failed, amodiaquine at a dose of 10mg/kg weekly and maloprim (half a tablet or one tablet depending on body weight, which gave ranges of dapsone of 1.7-3.3mg/kg and pyrimethamine 0.2-0.4 mg/kg) week ... | 1992 | 1341089 |
| differential antibody responses to plasmodium falciparum and p. vivax circumsporozoite proteins in a human population. | papua new guineans exposed to hyperendemic malaria in the madang area showed different antibody responses to plasmodium falciparum and plasmodium vivax sporozoites despite comparable entomological inoculation rates. although there was a significant trend of increasing prevalence of anti-p. falciparum circumsporozoite (cs) protein immunoglobulin g (igg) with age, there was no significant increase in the antibody units of igg recognizing p. falciparum cs proteins. antibodies recognizing p. vivax c ... | 1989 | 2666443 |