Publications

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investigation of malaria sporozoites by immunoradiometric assay.two-site immunoradiometric assay (irma) (zavala et al., 1982) using monoclonal antibodies to p. falciparum and p. vivax was applied to detect sporozoites in laboratory-maintained an. dirus and also mosquitoes collected from endemic areas of malaria in thailand. study in p. falciparum infected mosquitoes revealed that the circumsporozoite (cs) antigen was first found in the abdominal portion on day 10 post-infection, while it could be observed in the salivary glands from day 15 onwards. the head- ...19883043705
plasmodium falciparum and p. vivax circumsporozoite proteins in anophelines (diptera: culicidae) collected in eastern thailand.in total, 414 anophelines, consisting of anopheles karwari (james), an. splendidus koidzumi, an. dirus peyton & harrison, and an. barbirostris van der wulp were collected in 2 provinces in eastern thailand and tested by enzyme-linked immunosorbent assay for the presence of circumsporozoite proteins. plasmodium vivax cs protein was detected in 3.4% (2/54) of an. karwari and 4.8% (2/42) of an. barbirostris specimens. both p. vivax phenotypes, pv247 and pv210, were found in an. karwari, whereas onl ...19968961653
plasmodium vivax rhomboid-like protease 1 gene diversity in thailand.plasmodium vivax infection remains a major public health problem, especially along the thailand border regions. we examined the genetic diversity of this parasite by analyzing single-nucleotide polymorphisms (snps) of the p. vivax rhomboid-like protease 1 gene (pvrom1) in parasites collected from western (tak province, thai-myanmar border) and eastern (chanthaburi province, thai-cambodia border) regions.201728690071
antigenic diversity of plasmodium vivax and their geographic distribution in thailand.fifty-eight monoclonal antibodies (mabs) raised against the erythrocytic stages of plasmodium vivax were selected for typing of 501 p. vivax isolates from different geographic locations throughout thailand. based on their reactivities in the indirect fluorescent antibody test, these mabs were classified into five groups: group i mabs showing generalized staining of all blood stages; group ii mabs reacting with merozoites and their organelles; group iii mabs reacting with the surface membrane of ...199810437948
clinical response and susceptibility in vitro of plasmodium vivax to the standard regimen of chloroquine in thailand.the clinical effectiveness of the standard regimen of chloroquine (cq) (a total dose of 1500 mg, given over 48 h at 0, 6, 24 and 48 h) for the treatment of plasmodium vivax malaria in thailand was investigated in 57 patients in an endemic area of thailand (chantaburi province, eastern thailand). for radical treatment, an additional course of a tissue schizontocidal agent, primaquine, was given following the complete course of cq. with this regimen, satisfactory whole blood concentration-time pro ...19957570887
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