| comparison of oral artemether and mefloquine in acute uncomplicated falciparum malaria. | plasmodium falciparum malaria in thailand is highly resistant to available antimalarials, and alternative drugs are needed urgently. artemether is effective against falciparum malaria but associated with a high recrudescence rate. the proper dosage regimen remains to be defined. we have done a clinical trial comparing mefloquine 1250 mg in divided doses with oral artemether at 700 mg total dose given over 5 days in acute uncomplicated falciparum malaria. 46 patients, admitted to the bangkok hosp ... | 1992 | 1359318 |
| plasmodicidal effect of desferrioxamine b in human vivax or falciparum malaria from thailand. | desferrioxamine b (dfo, desferal), an iron chelator, was earlier shown to be active against plasmodium falciparum in vitro and in vivo. the present open pilot study served to assess its clinical tolerability and efficacy in human malaria under hospital conditions. continuous intravenous dfo was administered to 28 thai males at a dose of 100 mg/kg over 24 h for 3 consecutive days. no other antimalarial therapy was administered unless recrudescence had occurred. the first 14 patients had symptomat ... | 1992 | 1359761 |
| cutaneous delayed-type hypersensitivity responsiveness in patients during and after plasmodium falciparum and plasmodium vivax infections. | to assess cellular immune function in malaria, 61 patients admitted to the bangkok hospital for tropical diseases with plasmodium falciparum (pf) or plasmodium vivax malaria were examined with the multitest cmi system (merieux institute, florida) to evaluate delayed-type hypersensitivity (dth) during and after acute disease over 4 weeks. all patients demonstrated significantly decreased responsiveness to seven commonly encountered recall antigens. this deficit was most severe immediately upon ad ... | 1995 | 7554489 |
| comparison of oral artesunate and quinine plus tetracycline in acute uncomplicated falciparum malaria. | in thailand plasmodium falciparum malaria is highly resistant to available antimalarials. investigations on the efficacy of existing antimalarials and of alternative drugs are urgently needed. artesunate has been shown to be effective against falciparum malaria, but is associated with a high recrudescence rate. we have carried out a comparative clinical trial of the standard regimen of quinine + tetracycline versus oral artesunate at a 700-mg total dose given over 5 days to patients with acute u ... | 1994 | 8205643 |
| detection of plasmodium vivax by polymerase chain reaction in a field study. | detection and typing of plasmodium vivax by the polymerase chain reaction (pcr) was evaluated in a prospective blinded comparative field study in thailand. pcr amplification of the circumsporozoite (cs) gene was compared with microscopy for the detection of p. vivax in blood samples from 174 thai rangers and 50 malaria-free bangkok residents. for pcr analysis, filter paper specimens collected by finger prick were randomly processed and blindly interpreted for the presence of the cs gene of p. vi ... | 1993 | 8228373 |
| chloroquine sensitivity of plasmodium vivax in thailand. | chloroquine has been the standard treatment for plasmodium vivax malaria for more than 40 years in most regions of the world. recently, however, chloroquine-resistant p. vivax has been reported from oceania, several parts of asia, and south america. in order to assess the situation in thailand, 886 patients with vivax malaria who were admitted to the bangkok hospital for tropical diseases from 1992 to 1997 were followed prospectively. most of the patients had been infected on the western border ... | 1999 | 10562823 |
| frequency of pruritus in plasmodium vivax malaria patients treated with chloroquine in thailand. | chloroquine-induced itch in black-skinned african malaria patients is common and frequently leads to poor compliance or treatment defaulting.to assess the frequency and severity of chloroquine-induced pruritus in an asian population, we reviewed case records of 1189 plasmodium vivax malaria patients treated with chloroquine (25 mg/kg over 3 days) at the bangkok hospital for tropical diseases from 1992 through 1997. the majority of patients were thais or ethnic burmese (light brown skin), referre ... | 2000 | 11075653 |
| can treatment of p. vivax lead to a unexpected appearance of falciparum malaria? | of 994 patients admitted to the bangkok hospital for tropical diseases for p. vivax malaria, 104 (10.5%) experienced appearance of plasmodiumfalciparum following drug treatment for p. vivax . in all patients, p. falciparum parasites were not found by microscopic examination upon admission. the mean time for p. falciparum appearance was 12.6 days after the commencement of chloroquine treatment. patients experiencing appearance of p. falciparum had significantly lower hematocrit, and greater initi ... | 2001 | 11485096 |
| clinical trial of oral artesunate with or without high-dose primaquine for the treatment of vivax malaria in thailand. | we studied prospectively 801 thai patients admitted to the bangkok hospital for tropical diseases with acute, symptomatic plasmodium vivax malaria to determine the optimum duration of treatment with oral artesunate and the safety, tolerability, and effectiveness of a high dose of primaquine in prevention of relapse. patients were randomly assigned to one of four treatment groups: 1) a five-day course of artesunate (group a5); 2) a seven-day course of artesunate (group a7); 3) a five-day course o ... | 2003 | 12932090 |
| monitoring of plasmodium vivax sensitivity to chloroquine in vitro in thailand. | the sensitivity of plasmodium vivax to chloroquine in vitro was investigated in patients admitted to the bangkok hospital for tropical diseases, thailand, between september 2001 and may 2002. of 42 isolates, 34 were successfully tested for parasite sensitivity to chloroquine in vitro; the results showed a significant decrease in sensitivity compared with data published in 1989 and 1995: the ic50 and ic90 were 187.2 and 1217.9 ng/ml blood, respectively, an approximate 4-fold decrease in sensitivi ... | 2003 | 15259475 |
| risk factors for plasmodium vivax gametocyte carriage in thailand. | to study the risk factors for plasmodium vivax gametocyte carriage, the presence or absence of gametocytes was determined in 2,125 patients with p. vivax malaria participating in clinical trials at the hospital for tropical diseases in bangkok, thailand. stepwise logistic regression models were used to determine which variables were significantly related to gametocyte carriage. on admission, 615 patients (29%) had detectable gametocytes (before treatment). after treatment had started, an additio ... | 2004 | 15642956 |
| therapeutic efficacy of artesunate in plasmodium vivax malaria in thailand. | our previous study showed that in vitro susceptibility of plasmodium vivax to chloroquine has significantly decreased in thailand within the past two decades. thus, the evaluation of alternative antimalarials for treatment of vivax malaria is needed. the aim of this study was to examine parasitological and clinical efficacy of an artemisinin derivative (artesunate) for the treatment of vivax malaria in patients who were admitted to the bangkok hospital for tropical diseases. we randomly allocate ... | 2004 | 15689068 |
| efficacy of db289 in thai patients with plasmodium vivax or acute, uncomplicated plasmodium falciparum infections. | db289 is the orally active prodrug of the diamidine db75, which was developed for the treatment of human african trypanosomiasis. | 2005 | 15962227 |
| travelers' malaria among foreigners at the hospital for tropical diseases, bangkok, thailand - a 6-year review (2000-2005). | we retrospectively examined the charts of travelers admitted to the hospital for tropical diseases, bangkok, thailand, with malaria during the years 2000-2005. twenty-one cases of malaria were identified, of which 12 (57%) were plasmodium vivax infections and 9 (43%) were p. falciparum infections. there was one mixed case with vivax and falciparum infection. only 1 p. falciparum case had complications. all cases were successfully treated with standard antimalarial drugs. only 3 of the 21 cases w ... | 2006 | 16969060 |