| prevalence and clinical presentation of glucose-6-phosphate dehydrogenase deficiency in pakistani pathan and afghan refugee communities in pakistan; implications for the use of primaquine in regional malaria control programmes. | glucose-6-phosphate dehydrogenase (g-6-pd) deficiency surveys in afghan refugees and a local community in the north-west frontier province, pakistan, showed that this trait was most common among pathan and uzbak refugees (15.8% and 9.1% respectively). the prevalence among pakistani pathans was 7.0%, and that in tajik and turkoman refugees was 2.9% and 2.1% respectively. hospital studies showed that the type of g-6-pd deficiency in pathans could cause severe haemolytic crises. the potentially fat ... | 1995 | 7747310 |
| pattern of malarial infection diagnosed at ayub teaching hospital abbottabad. | malaria is endemic in abbottabad and the adjoining areas like many other parts of the country. depending upon the environmental conditions different species of malarial parasite are found in different areas. the present study was planned to see the pattern of malarial infection diagnosed at ayub teaching hospital, abbottabad. | 2007 | 18183716 |
| a randomised trial of an eight-week, once weekly primaquine regimen to prevent relapse of plasmodium vivax in northwest frontier province, pakistan. | vivax malaria remains a major cause of morbidity in the subtropics. to undermine the stability of the disease, drugs are required that prevent relapse and provide reservoir reduction. a 14-day course of primaquine (pq) is effective but cannot safely be used in routine practice because of its interaction with glucose-6-phosphate dehydrogenase (g6pd) deficiency for which testing is seldom available. safe and effective use of pq without the need for g6pd testing would be ideal. the efficacy and saf ... | 2008 | 18682739 |
| departmental audit of malaria control programme 2001-2005 north west frontier province (nwfp). | pakistan adopted the malaria control strategy with provincial commitment in 1998. pakistan joined the roll back malaria (rbm) initiative in 2001. this led to development of a 5 year roll back malaria strategy. the aim of the paper is to audit whether the malaria control programme in nwfp was able to implement strategies suggested by rbm initiative in the year 2002-2005, and its subsequent effect on the number of cases of malaria confirmed by peripheral blood smear/slide (confirmed cases), confir ... | 2008 | 19024199 |
| prevalence of antimalarial drug resistance mutations in plasmodium vivax and p. falciparum from a malaria-endemic area of pakistan. | to study drug resistance in bannu district, a malaria-endemic area in pakistan, molecular-based analyses were undertaken. in plasmodium vivax, antifolate resistance mutations were detected in pvdhfr gene codons 57, 58, and 117, with a 117n mutation frequency of 93.5%. all p. falciparum isolates exhibited double 59r + 108n mutations in pfdhfr, whereas the triple mutant 59r + 108n + 437g haplotype was found in 31.8% isolates. furthermore, all (100%) p. falciparum isolates exhibited the key chloroq ... | 2009 | 19706926 |
| genetic structure of plasmodium vivax and plasmodium falciparum in the bannu district of pakistan. | plasmodium vivax and plasmodium falciparum are the major causative agents of malaria. while knowledge of the genetic structure of malaria parasites is useful for understanding the evolution of parasite virulence, designing anti-malarial vaccines and assessing the impact of malaria control measures, there is a paucity of information on genetic diversity of these two malaria parasites in pakistan. this study sought to shed some light on the genetic structure of p. vivax and p. falciparum in this u ... | 2010 | 20416089 |
| population dynamics of mosquitoes and malaria vector incrimination in district charsadda, khyber pakhtunkhwa (kp) pakistan. | this study aimed to obtain updated information on mosquito diversity and malaria vector incrimination in charsadda khyber pakhtunkhwa to help in devising effective control and preventive measures in the area. monthly survey of indoor mosquitoes for one year was carried out in three villages, dhaki totaqi and mathra. female anopheline were used to detect circumsporozoites protein (csp) using enzyme linked immunosorbent assay. among 17 mosquito species, culex quinquefasciatus, anopheles splendidus ... | 2015 | 25255965 |