[mycobacteria tuberculosis bacteremia].mycobacterial bacteremia is common in patients with acquired immunodeficiency syndrome, and mycobacterium avium-intracellulare is isolated most frequently. although bacteremia due to mycobacterium tuberculosis was described as early as 1917, there are few recent reports regarding this phenomenon. however, mycobacterium tuberculosis infection is relative rare in those developed countries as compared to ours. it is estimated about 12,000 newly diagnosed tuberculous patients in taiwan area every ye ...19911646680
mycobacterial bacteraemia in patients infected and not infected with human immunodeficiency virus, taiwan.the clinical characteristics and outcomes of 71 patients with mycobacterial bacteraemia, infected with human immunodeficiency virus (hiv) (n = 47) and not infected with hiv (n = 24) are described. mycobacterium avium complex (mac) (54.9%) constituted the most frequently isolated mycobacterium, followed by mycobacterium tuberculosis (mtb) (38.0%), mycobacterium kansasii (4.2%), and mycobacterium abscessus (2.8%). the beijing family genotype was the most common type in mtb, and mycobacterium intra ...201019709128
comparison of the bactec mgit 960 with löwenstein-jensen medium for recovery of mycobacteria from clinical specimens.taiwan provincial chronic disease control bureau.200010985656
five-year experience of human immunodeficiency virus type 1 national screening program implemented at veterans general hospital-taipei.from july 1986 through june 1990, 33,199 sera from various risk groups were collected in veterans general hospital-taipei for detection of antibody against human immunodeficiency virus, type 1 (hiv-1). sixty-five samples were proved positive by western blot analysis. among individual high risk groups, hemophiliacs had the highest positive rate of 20/60 (29.41%), followed by homosexual/bisexual males (41/1,264, 3.24%). the overall positive rate was 65/33,199 (0.19%). ten cases were recognized as ...19938402370
use of soluble triggering receptor expressed on myeloid cells-1 in non-tuberculous mycobacterial lung disease.serum biomarkers are rarely studied in patients with non-tuberculous mycobacterial lung disease (ntm-ld).201122283904
nontuberculous mycobacterial infections in cancer patients in a medical center in taiwan, on the nontuberculous mycobacterial (ntm) species that cause infection and the characteristics of disease caused by these pathogens in cancer patients are limited, so we perform this study to investigate the species distribution of ntm isolates from various clinical specimens and to elucidate the epidemiologic trends in ntm isolates and diseases among cancer patients. from 2005 through 2008, cancer patients with ntm infections as defined by the american thoracic society/infectious diseases ...201122137681
mycobacterial peritonitis: difference between non-tuberculous mycobacteria and mycobacterium tuberculosis.clin microbiol infect abstract: unlike tuberculous peritonitis, peritonitis due to non-tuberculous mycobacteria (ntm) has unclear clinical manifestations. this study aimed to clarify the clinical manifestations and laboratory results of ntm peritonitis and compare it to tuberculous peritonitis. this retrospective study was conducted from 2000 to 2008 in a medical centre in taiwan. patients with mycobacteria isolated from ascites were identified and compared according to causative pathogens (myco ...201121631640
pot shots.certain hiv drugs have significant side effects. there have been reports from europe that some hemophiliacs using protease inhibitors suffered from spontaneous bleeding. clofazimine, sold as lamprene, has been shown to cause harm when used with clarithromycin and ethambutol to treat mac. lamprene may cause internal bleeding, nausea, diarrhea, dizziness, drowsiness, and dry skin. results of a taiwanese trial of thymosin-alpha indicate that it did not help treat hepatitis b in a statistically sign ...199611363915
non-tuberculous mycobacterial pleurisy: an 8-year single-centre experience in investigate the clinical characteristics and outcomes of patients with pleurisy due to non-tuberculous mycobacteria (ntm), which are currently unclear.201020392359
increasing incidence of nontuberculous mycobacteria, taiwan, assess the species distribution and epidemiologic trends of nontuberculous mycobacteria, we examined isolates from patients in taiwan. during 2000-2008, the proportion increased significantly from 32.3% to 49.8%. associated disease incidence increased from 2.7 to 10.2 cases per 100,000 patients. mycobacterium avium complex and m. abscessus were most frequently isolated.201020113563
emergence of disseminated infections due to nontuberculous mycobacteria in non-hiv-infected patients, including immunocompetent and immunocompromised patients in a university hospital in taiwan.although disseminated nontuberculous mycobacteria (ntm) infection has been increasingly reported in patients with aids, this condition is still considered rare in non-hiv-infected patients.200616313964
clinical features and outcomes of disseminated infections caused by non-tuberculous mycobacteria in a university hospital in taiwan, 2004-2008.this retrospective study investigated the clinical characteristics and prognostic factors of patients with disseminated infections caused by non-tuberculous mycobacteria (ntm) in taiwan. forty patients who fulfilled the criteria for disseminated ntm infection at a medical centre from january 2004 to december 2008 were analyzed. more than half of the patients (n = 22, 55%) were hiv-infected and fever was the most common initial presentation (n = 21, 52.5%). there were 13 episodes of co-infection ...201120849364
factors associated with subsequent nontuberculous mycobacterial lung disease in patients with a single sputum isolate on initial examination.very few studies have focused on the outcome and management of patients with a single sputum isolate of nontuberculous mycobacterium (ntm) on initial examination. patients with a single isolate of mycobacterium avium complex (mac), m. chelonae-abscessus, m. kansasii, or m. fortuitum from at least three sputum samples collected within 1 month were retrospectively identified. those with follow-up sputum samples within 1 year were included in the analysis. among the 202 patients included, m. fortui ...201525658545
CNS infections caused by Mycobacterium abscessus complex: clinical features and antimicrobial susceptibilities of isolates.Objectives CNS infections caused by non-tuberculous mycobacteria (NTM) are rare and only three cases of CNS infections due to Mycobacterium abscessus complex have been reported. Methods We searched the Mycobacteriology Database of the National Taiwan University Hospital and identified patients with CNS infections due to NTM. Results A total of 15 patients, namely 4 HIV-seropositive patients and 11 HIV-seronegative patients, with CNS infections caused by NTM were identified during 2000-10. All ...201221980068
isolation of non-tuberculous mycobacteria from hospital cockroaches (periplaneta americana).this study attempted to isolate mycobacteria from hospital and household cockroaches from 90 hospitals and 40 households in kaohsiung city and kaohsiung county, south taiwan. among 203 cockroaches (139 periplaneta americana and 64 blattella germanica) collected from the hospitals, six mycobacterium spp. were isolated and identified by polymerase chain reaction-restriction fragment length polymorphism analysis. in 12 cockroaches (p. americana): four mycobacterium kansaii, three mycobacterium xeno ...200312623325
genitourinary infections caused by nontuberculous mycobacteria at a university hospital in taiwan, 1996-2008.genitourinary infections caused by nontuberculous mycobacteria (ntm) are rarely reported. the medical records of all patients with genitourinary ntm infections treated at national taiwan university hospital from 1996-2008 were retrospectively reviewed. fifteen patients were identified, of whom 10 (67%) were male. more than two-thirds of patients had underlying conditions, the most common of which was chronic renal disease. only one patient had aids. acid-fast smears of urine were negative in all ...201020132253
clinical features and outcome in disseminated mycobacterial diseases in aids patients in describe and compare the clinical features and outcome of disseminated tuberculosis (tb) and mycobacterium avium complex (mac) disease in aids patients.19989708409
nontuberculosis mycobacterium disease is a risk factor for chronic obstructive pulmonary disease: a nationwide cohort study.the aim of this study was to evaluate the association between chronic obstructive pulmonary disease (copd) and nontuberculosis mycobacterium (ntm) disease.201424691889
serodiagnosis of mycobacterium avium complex disease in humans: translational research from basic mycobacteriology to clinical medicine.rapid and accurate diagnosis of infectious diseases, including mycobacterial disease such as tuberculosis (tb) and diseases due to nontuberculous mycobacteria (ntm), is a very important element of global health. the gold standard in diagnosis of mycobacterial diseases remains clinical examination, combined with direct microscopic examination of sputum and culture of bacteria. culture of slowly growing mycobacteria, including mycobacterium tuberculosis and ntm (such as m. avium complex: mac), can ...201425241680
clinical significance of isolation of mycobacterium avium complex from respiratory specimens.mycobacterium avium complex (mac) is frequently considered to be a contaminant or transient colonizer. to the best of our knowledge, there have been very few reports regarding the clinical significance of mac isolates in respiratory specimens, and the associated disease spectrum in taiwan. the purpose of this study was to investigate the clinical significance of mac isolates in respiratory specimens.201020654791
pulmonary infection caused by nontuberculous mycobacteria in a medical center in taiwan, 2005-2008.the aim of this study was to investigate the epidemiology and clinical characteristics of pulmonary infections caused by nontuberculous mycobacteria (ntm) in a university hospital in taiwan from 2005 to 2008. during the study period, a total of 312 patients with ntm pulmonary infection were identified. most patients with ntm pulmonary infection had preexisting pulmonary diseases or malignancies. the incidence (per 100,000 inpatients and outpatients) of patients with ntm isolations (6.67 in 2005 ...201222015322
lymphadenitis caused by non-tuberculous mycobacteria in a university hospital in taiwan: predominance of rapidly growing mycobacteria and high recurrence rate.lymphadenitis is the most common manifestation of infection due to non-tuberculous mycobacteria (ntm) in otherwise healthy children. this disease is rare in adults and its geographic variations in etiology and clinical manifestations remain unclear. the aim of this study was to describe the etiology, clinical presentation, treatment, and outcome of ntm lymphadenitis.200516607446
clinicopathologic characteristics of nontuberculous mycobacterial lung disease in taiwan.taiwan is an endemic area for tuberculosis (tb), and the incidence of pulmonary infection caused by nontuberculous mycobacteria (ntms) is also increasing. this study aims to investigate the clinicopathologic characteristics of patients with ntm lung disease during 1998 to 2007 at a medical center in taiwan. the medical records of patients with confirmed ntm pulmonary infections who underwent open lung surgery in a medical center were reviewed. twenty-four patients with confirmed ntm pulmonary in ...201020846814
changes in the clinical spectrum of opportunistic illnesses in persons with hiv infection in taiwan in the era of highly active antiretroviral therapy.we compared changes in the relative frequencies of opportunistic illnesses (ois) among 1,044 taiwanese persons with hiv infection who were enrolled in three study periods from june 1994 to june 2004: before the introduction of highly active antiretroviral therapy (haart); early haart; and late haart. nearly two-thirds of those newly diagnosed with hiv infection had cd4 counts below 200/mm(3). among a total of 1,182 ois, candidiasis, pneumocystis carinii pneumonia, and tuberculosis were the most ...200617060697
disease caused by non-tuberculous mycobacteria in a university hospital in taiwan, 1997-2003.from january 1997 to december 2003, all patients with non-tuberculous mycobacteria (ntm) isolation who were treated at a university hospital in taiwan were evaluated. among the 2650 ntm isolates, 1225 (46.2%) were from 412 patients with clinically significant diseases. the annual incidence (per 100000 patients) of disease caused by ntm was 8.96 in 1997, 21.53 in 2002, and 16.55 in 2003. the major types of infections caused by ntm included isolated pulmonary infection and pleurisy (59.5%), skin/s ...200616492317
clinical significance of nontuberculous mycobacteria isolates in elderly taiwanese patients.the aim of this study was to investigate the clinical significance of nontuberculous mycobacteria (ntm) isolates in elderly taiwanese patients. from 2004 through 2008, patients >65 years old with ntm isolation were identified. the definitions of ntm disease followed the american thoracic society and infectious disease society of america (ats/idsa) criteria. among the 3,175 ntm isolates, mycobacterium avium complex (mac; n = 1,118, 35.2%) was the most prevalent species, followed by m. abscessus ( ...201121240651
the trend and the disease prediction of vascular endothelial growth factor and placenta growth factor in nontuberculous mycobacterial lung disease.nontuberculous mycobacteria (ntm)-lung disease (ld) is an increasing health problem worldwide. the diagnosis of this disease remains difficult, however the application of placenta growth factor (plgf) and vascular endothelial growth factor (vegf) has not yet been studied. we screened patients with mycobacterium avium complex or m. abscessus isolated from sputum, and enrolled 32 patients with ntm-ld and 93 with ntm pulmonary colonization. the ntm-ld group had a lower body mass index, higher propo ...201627876856
clinical features of patients with bacteraemia caused by mycobacterium avium complex species and antimicrobial susceptibility of the isolates at a medical centre in taiwan, 2008-2014.advanced molecular typing methods have greatly expanded the taxonomy of mycobacterium avium complex (mac) species; however, little is known about the epidemiology and clinical features of bacteraemia caused by different mac species. in this study, the clinical characteristics of patients treated for mac bacteraemia in a tertiary-care centre in northern taiwan during 2008-2014 were investigated. isolates were identified to species level by rpob gene and 16s-23s rrna internal transcribed spacer re ...201728478210
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