novel human in vitro system for evaluating antimycobacterial vaccines.major research efforts are directed towards the development of a better antimycobacterial vaccine. but progress in the field of tuberculosis vaccine development has been hampered by the lack of human in vitro models to assess vaccine immunogenicity and efficacy. new candidate vaccines will have to be evaluated against the existing mycobacterium bovis bcg "gold standard." it is therefore important to understand the type of immune responses elicited by bcg vaccination to enable comparisons with po ...200415501770
the risk of disseminated bacille calmette-guerin (bcg) disease in hiv-infected children.bacille calmette-guerin (bcg), a live attenuated mycobacterium bovis vaccine, poses a risk to human immunodeficiency virus (hiv)-infected children; this risk has not been well quantified. we estimate the risk of disseminated bcg disease in hiv-infected children in a setting highly endemic for tuberculosis and hiv.200716959383
the impact of a change in bacille calmette-guérin vaccine policy on tuberculosis incidence in children in cape town, south africa.a decision by the south african national department of health to change the route of administration and strain of bacille calmette-guérin (bcg) vaccine was implemented in cape town, south africa, between july and december 2000. this provided an opportunity to compare the incidence of tuberculosis and proportion with disseminated disease in children less than 2 years old before and after the changeover from percutaneous (pc) tokyo 172 bcg to intradermal (id) 1331 danish bcg immunization.200617133164
actinomadura rudentiformis sp. nov., isolated from part of an antibiotic-screening programme, the actinomycete strain hmc1(t) was isolated from soil collected from the banks of the gamka river in the swartberg nature reserve, western cape province, south africa. the isolate produced branching vegetative mycelia, which entwined to form rope-like structures. it exhibited antibiosis against enterococcus faecium vana (a vancomycin-resistant clinical strain) and mycobacterium aurum a+. organic solvent extracts of the culture filtrate and mycelial ...200717220439
diagnosing mycobacterial lymphadenitis in children using fine needle aspiration biopsy: cytomorphology, zn staining and autofluorescence -- making more of less.although the incidence of tb has stabilized or declined in most world regions, it is increasing in africa, southeast asia, and the eastern mediterranean, fuelled by the hiv pandemic. more than 4,000 people died daily from tb-related illnesses in 2005. tb is a major cause of childhood morbidity and mortality in these developing countries, and there is an urgent need for rapid and definitive modalities for mycobacterial diagnosis in children. this prospective study in tygerberg hospital, cape town ...200818335554
risk factors associated with indeterminate gamma interferon responses in the assessment of latent tuberculosis infection in a high-incidence environment.the performance of gamma interferon (ifn-γ) release assays (igra) in the detection of latent tuberculosis (tb) infection is limited by the higher rates of indeterminate results in hiv-infected persons, who bear the brunt of tb disease in some high-burden settings. the objective of the study was to evaluate predictors of indeterminate igra results in the overall study population and in hiv-infected persons. the study setting is khayelitsha, an informal township in the western cape of south africa ...201222718129
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