| failure of the mycobacterium bovis bcg vaccine: some species of environmental mycobacteria block multiplication of bcg and induction of protective immunity to tuberculosis. | the efficacy of mycobacterium bovis bacillus calmette-guérin (bcg) vaccine against pulmonary tuberculosis (tb) varies enormously in different populations. the prevailing hypothesis attributes this variation to interactions between the vaccine and mycobacteria common in the environment, but the precise mechanism has so far not been clarified. our study demonstrates that prior exposure to live environmental mycobacteria can result in a broad immune response that is recalled rapidly after bcg vacci ... | 2002 | 11796598 |
| gamma interferon responses induced by a panel of recombinant and purified mycobacterial antigens in healthy, non-mycobacterium bovis bcg-vaccinated malawian young adults. | we have previously shown that young adults living in a rural area of northern malawi showed greater gamma interferon (ifn-gamma) responses to purified protein derivatives (ppd) prepared from environmental mycobacteria than to ppd from mycobacterium tuberculosis. in order to define the mycobacterial species to which individuals living in a rural african population have been exposed and sensitized, we tested t-cell recognition of recombinant and purified antigens from m. tuberculosis (38 kda, mpt6 ... | 2003 | 12853392 |
| distribution of environmental mycobacteria in karonga district, northern malawi. | the genus mycobacterium includes many species that are commonly found in the environment (in soil and water or associated with plants and animals), as well as species that are responsible for two major human diseases, tuberculosis (mycobacterium tuberculosis) and leprosy (mycobacterium leprae). the distribution of environmental mycobacteria was investigated in the context of a long-term study of leprosy, tuberculosis, mycobacterium bovis bcg vaccination, and the responses of individuals to vario ... | 2006 | 16597928 |