| antibody to human retroviruses among drug users in three east coast american cities, 1972-1976. | between 1972 and 1976, 585 persons attending methadone maintenance clinics at east coast veterans hospitals were enrolled in a survey of hepatitis antibody prevalence. sera were tested for human immunodeficiency virus (hiv) and human t lymphotropic virus (htlv) using both htlv-i and htlv-ii immunoblots. clinical and death records were also reviewed. none of the sera had hiv antibodies (upper 95% confidence limit, 0.5%); however, 103 (18%) had reactivity to htlv. the profile of reactivity suggest ... | 1991 | 1670608 |
| quantitative estimation by a standardized enzyme-linked immunosorbent assay of human t-cell lymphotropic virus type i antibodies in adult t-cell leukemia and acquired immune deficiency syndrome. | sera from patients with adult t-cell leukemia and asymptomatic carriers of human t-cell lymphotropic virus type i (htlv-i) from widely separated areas of the world reacted strongly in a standardized quantitative enzyme-linked immunosorbent assay procedure with htlv-i viral antigen prepared from a strain isolated in the united states. there was a sharp differentiation of the values seen in the patients as compared with a normal population. of the 35 acquired immune deficiency syndrome patients wi ... | 1986 | 3009530 |
| human t-cell lymphotropic virus infection among blood donors in south florida. the transfusion safety study group. | knowledge of the epidemiologic pattern of human t-lymphotropic virus (htlv) in the united states is being enlarged by blood donor screening. we tested stored sera from 29,937 donations made in south florida in 1984-1985. twenty-three donors were confirmed as seropositive, a prevalence of 0.8 per 1,000 donations. specificity was supported by serologic retesting and virus culture of 11 donors located for follow-up. sex- and age-specific prevalences did not differ significantly; blacks, however, ac ... | 1991 | 1670589 |
| human t lymphotropic virus type i-associated myelopathy. a report of 10 patients born in the united states. | human t lymphotropic virus type i (htlv-i)-associated myelopathy (ham) (tropical spastic paraparesis/ham) has rarely been reported in the united states. we present 10 well-documented cases with positive western immunoblot test results and polymerase chain reactions for htlv-i. the clinical and laboratory features of these american-born patients resemble those previously reported series of tropical spastic paraparesis and ham from the caribbean and japan, but important differences were observed. ... | 1992 | 1444875 |
| geographic distribution of htlv-i and identification of a new high-risk population. | epidemiologic studies indicate that human t-cell lymphotropic virus type i (htlv-i), the causative agent of most cases of adult t-cell leukemia/lymphoma (atll) in southeast japan and the caribbean islands and the probable cause of a progressive neurological disorder often referred to as tropical spastic paraparesis, occurs with unusual geographic clustering. the current large-scale serosurvey was undertaken to improve our understanding of htlv-i prevalence in different parts of the world. we ana ... | 1988 | 2899060 |
| human immunodeficiency virus and human t-cell leukemia virus type i in patients undergoing maintenance hemodialysis in miami. | the high prevalence of human immunodeficiency virus (hiv-1) infection in populations at risk in miami prompted a seroepidemiologic study of both hiv-1 and the human t-cell leukemia virus type i (htlv-i), a closely related virus, in our patients receiving chronic hemodialysis. one hundred twenty-nine patients undergoing hemodialysis in 1986 and 1987 were tested for antibody against both viral antigens by eia (abbott laboratories, abbott park, il). seroreactive samples for hiv-1 and/or htlv-i were ... | 1989 | 2787117 |
| hiv-1 and htlv-i infection in renal transplant recipients. | the prevalence of retroviral infection in renal transplantation remains poorly defined. we tested retrospectively sera from 224 of 331 patients undergoing renal transplantation between 1979 and 1985. viral antigen based eia was used for screening igg antibodies to human immunodeficiency virus (hiv-i) and human t-cell leukemia virus type i (htlv-i). positive eias were confirmed by western blot. six patients (2.7%) were found to have retroviral infection, four with hiv-1 and two with htlv-i. the f ... | 1990 | 2403436 |
| htlv-i-associated myelopathy associated with blood transfusion in the united states: epidemiologic and molecular evidence linking donor and recipient. | six months after receiving 58 units of blood components, a 65-year-old white man from new york city, with no other risk factors for human t-lymphotropic virus type i (htlv-i) infection, developed htlv-i-associated myelopathy/tropical spastic paraparesis (ham/tsp). investigation of blood donors identified a 25-year-old white hispanic woman from florida whose platelets had been given to the patient and who was seropositive for the virus on a serum specimen obtained 2 years after the donation. she ... | 1991 | 1992361 |
| htlv-ii risk factors in native americans in florida. | earlier virologic studies established that human t-cell lymphotropic virus type ii (htlv-ii) is the predominant retrovirus type found among seminole indians in southern florida. we studied 46 members of the seminole tribe living on 3 reservations to determine the risk factors for htlv-ii and to investigate disease association with the virus. the donors' plasma samples were evaluated with the enzyme-linked immunosorbent and western blot assays. dna extracted from their peripheral blood mononuclea ... | 1999 | 9831814 |
| predictors of survival in human immunodeficiency virus type 1-seropositive intravenous drug users. | in an ongoing prospective study of street-recruited intravenous drug users (idus) in miami, fla., 116 human immunodeficiency virus type 1 (hiv-1)-infected idus were monitored for up to 7 years. this provided an opportunity to evaluate baseline immunological parameters as potential predictors of survival among hiv-1-infected idus. as expected, hiv-1-infected idus who had an advanced stage of the disease (centers for disease control and prevention classification iii or iv); p24 antigenemia; human ... | 1996 | 8770504 |
| htlv-ii infection in florida indians. | a significantly increased prevalence of antibodies to human t-cell leukemia virus (htlv) has been described in several native american populations in the united states and latin america. initial virologic studies indicate that htlv-ii is the predominant virus responsible for this antibody pattern. we obtained blood samples from 106 seminole indians living on four reservations in southern florida. seropositivity to htlv-i/ii was found in 14 (13.2%) of these individuals. polymerase chain reaction ... | 1993 | 8457379 |
| clinical spectrum of htlv-i in south florida. | a total of 113 patients with infection due to human t-cell leukemia virus type 1 (htlv-i) were evaluated at the university of miami from january 1988 to march 1993. forty patients were identified with adult t-cell leukemia/lymphoma (atll) and 63 with htlv-i-associated myelopathy (ham). three had concomitant atll and ham. two ham patients co-infected with human immunodeficiency virus type 1 (hiv-i) developed clonal lymphoproliferative disease during the study period. patients with atll have a poo ... | 1995 | 7697443 |
| htlv-i-associated leukemia/lymphoma in south florida. | we report here 10 cases of adult t-cell leukemia/lymphoma (atl) seen in south florida between february 1988 and july 1989. all were seropositive for human t-lymphotropic virus type i (htlv-i) and seronegative for human immunodeficiency virus type 1 (hiv-1). dna extracted from tumor biopsies/peripheral blood lymphocytes of nine patients was shown by the polymerase chain reaction (pcr) to contain htlv-i proviral dna. blot hybridization of dna extracted from seven patients with an htlv-i cdna probe ... | 1991 | 1992105 |