| high prevalence of sjögren's syndrome in patients with htlv-i associated myelopathy. | a high seroprevalence of htlv-i in female sjögren's syndrome (ss) patients has been reported in nagasaki, japan, an area that is heavily endemic for htlv-i infection. salivary iga class antibodies to htlv-i were common among htlv-i seropositive patients with ss. this study was undertaken to elucidate the pathogenesis of ss caused by htlv-i infection. | 1997 | 9135218 |
| high seroprevalence of anti-htlv-i antibody in rheumatoid arthritis. | to investigate the association between human t lymphotropic virus type i (htlv-i) infection and rheumatoid arthritis (ra) in nagasaki, an area highly endemic for htlv-i infection. | 1996 | 8607895 |
| mortality among inhabitants of an htlv-i endemic area in japan. | a community-based cohort study was conducted to clarify the risk of human t-cell leukemia virus type i (htlv-i) infection for cause-specific deaths. a total of 1,997 individuals (751 men and 1,246 women) aged 30 or older in a-island, nagasaki prefecture, japan who had voluntarily attended annual mass health examinations, including serum htlv-i antibody test, were followed up for a mean period of 5.3 years. in a cox proportional hazards analysis adjusted for age at baseline, the htlv-i seropositi ... | 1994 | 8188520 |
| anti-human t-lymphotropic virus type-i antibodies in atomic-bomb survivors. | adult t-cell leukemia (atl), induced by human t- lymphotropic virus type-i (htlv-i), is endemic in nagasaki, japan. to investigate the effects of atomic-bomb radiation on development of this specific type of leukemia, 6182 individuals in the radiation effects research foundation (rerf) adult health study sample in hiroshima and nagasaki were examined for positive rate of htlv-i antibody. several lymphocyte parameters were also studied for 70 antibody- positive subjects in nagasaki. the htlv-i an ... | 1995 | 7616489 |
| aids studies in japan. | the aids surveillance system in japan was set up in 1984 and by 1987, 29 aids patients had been reported. 10 were homosexuals, 16 were hemophiliacs and 3 were heterosexuals. 9 out of 16 hemophiliacs with aids had a-type hemophilia. 2 females were also reported as victims of aids. 19 patients have died 5 male homosexuals (4.4%) out of 113 (93 japanese and 20 foreigners) individuals were anti-hiv-positive. in 1984 sera from 65 hemophiliacs, 85 hemodialysis patients and 304 healthy volunteer b ... | 1987 | 3112053 |
| human t-lymphotropic virus type i(htlv-i) associated myelopathy in nagasaki: clinical features and treatment of 21 cases. | the clinical features of 21 patients (7 men and 14 women, aged 24-65) with human t-lymphotropic virus type i (htlv-i) associated myelopathy (ham) in nagasaki were reviewed. gait disturbance with spastic paraplegia and bladder dysfunction were the main clinical symptoms. gait disturbance was observed in all patients and bladder dysfunction was found in 20/21 (95.2%). mild sensory disturbance was observed in 11/21 (52.3%) patients. only 4 patients had received blood transfusions before the onset o ... | 1989 | 2661889 |
| prevention of mother-to-child transmission of human t-lymphotropic virus type-i. | human t-cell lymphotropic virus type i (htlv-i), an etiologic human retrovirus of adult t-cell leukemia/lymphoma (atll), causes approximately 60 new cases of atll each year in nagasaki prefecture; essentially all cases are fatal, and they account for approximately 0.5% of total deaths in the area. the estimated life risk for an htlv-i carrier to develop atll is approximately 5%. the major transmission pathway of htlv-i peculiarly endemic in the nagasaki prefecture was studied. the prevalence of ... | 1990 | 2359666 |
| detection of preleukemic state of adult t-cell leukemia (pre-atl) in htlv-1 carriers. | the prevalence of the preleukemic state of adult t-cell leukemia (pre-atl) was studied in nagasaki prefecture, one of the endemic human t-lymphotropic virus type 1 (htlv-1) areas in japan. pre-atl cases have the monoclonal proliferation of abnormal lymphocytes, without signs of malignant proliferation or clinical signs and symptoms related to leukemia. htlv-1 carriers who have monoclonal integration of htlv-1 proviral dna may be at high risk of developing atl. abnormal lymphocytes with either bi ... | 1990 | 2224908 |
| amplification of htlv-1-related sequences among patients with neurological disorders in highly endemic nagasaki: lack of evidence for association of htlv-1 with multiple sclerosis. | we studied dna sequences homologous to htlv-1 in peripheral blood mononuclear cells (pbmc) of 30 patients with neurological disorders in kyushu, where htlv-1 is highly endemic. the regions of htlv-1 amplified by means of polymerase chain reaction (pcr) included u3, u5, gag, pol, env and px. our system specifically detected htlv-1 sequences only from htlv-1-positive cells and was sufficiently sensitive to detect one proviral copy per 10(3) pbmc. all pcr-positive cases were seropositive, including ... | 1990 | 2112526 |
| [epidemiology of htlv-i carriers in hirado island and virological and immunological investigation of htlv-i associated pulmonary disease]. | adult t-cell leukemia (atl) is endemic in kyushu. our study at hirado island in nagasaki prefecture revealed a higher incidence (35.9%) of htlv-i carriers in villages with fishing than in those without (16.5%). htlv-i carriers showed a higher incidence of abnormal findings on chest roentgenogram (21.7%) than non-carriers (16.5%), but most were lesions of old pulmonary tuberculosis and pleural thickening. virological and immunological investigations were performed for 10 htlv-i carriers, 3 patien ... | 1992 | 1630038 |
| trends in htlv-1 prevalence and incidence of adult t-cell leukemia/lymphoma in nagasaki, japan. | most previous studies aimed at estimating the number of human t-cell leukemia virus type-1 (htlv-1) carriers in endemic areas have been based on seroprevalence rates in blood donors; however, this may result in underestimation because of the healthy donor effect. people who have health problem do not donate blood. in the present study, the number of htlv-1 carriers in nagasaki city was estimated based on the seroprevalence rates in a hospital-based population from nagasaki university hospital. i ... | 2010 | 20166187 |
| trends in the seroprevalence of htlv-1 in japanese blood donors in nagasaki prefecture, 2000-2006. | human t cell leukemia virus type-1 (htlv-1) is the established cause of adult t cell leukemia/lymphoma. monitoring time trends in htlv-1 seroprevalence in blood donors is important to assess the safety of the blood supply in the viral endemic area. we analyzed changes in htlv-1 seroprevalence in 48415 first-time blood donors who donated blood from 2000 to 2006 in nagasaki prefecture, an endemic area in japan. the donors were divided into 10-year birth cohorts: before 1950, 1951-1960, 1961-1970, ... | 2009 | 19548067 |
| human t-cell lymphotropic virus type-1 infection and risk of cancer: 15.4 year longitudinal study among atomic bomb survivors in nagasaki, japan. | the objective of the present study was to investigate the association between human t-lymphotropic virus type-1 (htlv-1) infection and cancer risk in a longitudinal study. the study population consisted of 2729 atomic bomb survivors in nagasaki prefecture, japan, who had no previous history of cancer at baseline. the baseline survey, including analysis of antibody to htlv-1, took place during 1985-1987 and follow-up was performed until the end of 2001. there were 553 incident cases of malignant ... | 2006 | 16734733 |
| human t-lymphotropic virus type-i infection, survival and cancer risk in southwestern japan: a prospective cohort study. | this study prospectively evaluated the associations of human t-lymphotropic virus type-i (htlv-i) infection with survival and cancer incidence. | 2003 | 14682446 |
| the current status of therapy for adult t-cell leukaemia-lymphoma in japan. | more than 25 years have passed since adult t-cell leukaemia-lymphoma (atll) was identified as a distinct clinical entity clustered in the southwestern part of japan. during these years, its causative agent, human t-cell leukaemia virus type i (htlv-i), was found, and remarkable clinical variance of this disease was recognized afterward. because of the regional occurrence of this disease in the world, young medical scientists whose community is not endemic for this disease may have little underst ... | 2003 | 12769337 |
| geographic distribution of the incidence of adult t-cell leukemia/lymphoma and other malignancies in nagasaki prefecture, japan. | it remains unclear whether human t-cell lymphotropic virus type-i (htlv-i) infection is associated with an increased risk of malignancies other than adult t-cell leukemia/lymphoma. | 2002 | 12411568 |
| cytogenetic analysis and clinical significance in adult t-cell leukemia/lymphoma: a study of 50 cases from the human t-cell leukemia virus type-1 endemic area, nagasaki. | identification of cytogenetic abnormalities is an important clue for the elucidation of carcinogenesis. however, the cytogenetic and clinical significance of adult t-cell leukemia/lymphoma (atll) is still unclear. to address this point, cytogenetic findings in 50 cases of atll were correlated with clinical characteristics. karyotypes showed a high degree of diversity and complexity. aneuploidy and multiple breaks (at least 6) were observed frequently in acute and lymphoma subtypes of atll. break ... | 2001 | 11369658 |
| decline in the positive rate of human t-lymphotropic virus type-1 (htlv-1) antibodies among blood donors in nagasaki. | the aim of this study was to clarify the trend of the htlv-1 seroprevalence rate among blood donors. | 2001 | 11201362 |
| low prevalence of helicobacter pylori in individuals with htlv-i infection. | the prevalence of helicobacter pylori in hiv-positive individuals is significantly lower than in hiv-negative controls. however, its prevalence in individuals infected with human t-cell leukaemia virus type i (htlv-i), another important member of the human retrovirus family, has not been previously investigated. | 1999 | 10755252 |
| relationship between sjögren's syndrome and human t-lymphotropic virus type i infection: follow-up study of 83 patients. | we have previously demonstrated a high prevalence of sjögren's syndrome (ss) in patients with human t-lymphotropic virus type i-associated myelopathy (ham) in nagasaki prefecture. the present follow-up study compared the clinical and laboratory findings of ss with or without human t-lymphotropic virus type i (htlv-i) antibody in this endemic area for htlv-i infection. we investigated the clinical and laboratory manifestations in 83 patients with ss and ham, including histologic examination of la ... | 2000 | 10695658 |
| low copy numbers of human t-cell lymphotropic virus type i (htlv-i) tax-like dna detected in the salivary gland of seronegative patients with sjögren's syndrome in an htlv-i endemic area. | to evaluate the hypothesis, proposed in previous reports from htlv-i non-endemic areas, that htlv-i is involved in a significant proportion, about a quarter, of sjögren's syndrome patients who lack serum antibodies to the virus, we examined for the presence or absence of htlv-i in dna samples isolated from salivary gland tissues of 17 seronegative as well as 7 seropositive patients with sjögren's syndrome in nagasaki, japan, where the virus is highly endemic. the nested two-step polymerase chain ... | 1998 | 9855214 |
| human t-lymphotropic virus type-i infection, antibody titers and cause-specific mortality among atomic-bomb survivors. | there have been few longitudinal studies on the long-term health effects of human t-lymphotropic virus type-i (htlv-i) infection. the authors performed a cohort study of htlv-i infection and cause-specific mortality in 3,090 atomic-bomb survivors in nagasaki, japan, who were followed from 1985-1987 to 1995. the prevalence of htlv-i seropositivity in men and women was 99/1,196 (8.3%) and 171/1,894 (9.0%), respectively. during a median follow-up of 8.9 years, 448 deaths occurred. there was one non ... | 1998 | 9765614 |
| primary prevention of htlv-1 in japan. | the nagasaki prefecture, japan (population: 1.5 million), is one of the hot endemic foci of human t-lymphotropic virus type 1 (htlv-1). prevalence of htlv-1 carriers are approximately 10% in the age group over 40 years old (40,000 individuals), approximately 10 times of the national average. annual registry of adult t-cell leukemia (atl) in the prefecture is approximately 60 cases (estimated incidence: 100 cases), or a half percent of total deaths. a effective measure to control the endemic cycl ... | 1997 | 9209297 |
| establishment of the milk-borne transmission as a key factor for the peculiar endemicity of human t-lymphotropic virus type 1 (htlv-1): the atl prevention program nagasaki. | in late 2010, the nation-wide screening of pregnant women for human t-lymphotropic virus type 1 (htlv-1) infection was implemented in japan to prevent milk-borne transmission of htlv-1. in the late 1970s, recognition of the adult t-cell leukemia (atl) cluster in kyushu, japan, led to the discovery of the first human retrovirus, htlv-1. in 1980, we started to investigate mother-to-child transmission (mtct) for explaining the peculiar endemicity of htlv-1. retrospective and prospective epidemiolog ... | 2011 | 21558754 |
| evaluation of adult t-cell leukemia/lymphoma incidence and its impact on non-hodgkin lymphoma incidence in southwestern japan. | the incidence of adult t-cell leukemia/lymphoma (atl) and its impact on that of total non-hodgkin lymphoma (nhl) were evaluated in nagasaki, an area in southwestern japan where human t-cell lymphotropic virus type i (htlv-i) is endemic. the first study area comprised 4 towns located on the k islands, which had a population of 26,870 in 1990. the overall htlv-i seroprevalence estimated from the serologic survey of 18,485 subjects was 16.2%. by using the data from the nagasaki prefectural cancer r ... | 2000 | 10652420 |
| a nested case-control study of risk factors for adult t-cell leukemia/lymphoma among human t-cell lymphotropic virus type-i carriers in japan. | the purpose of this study was to investigate the serological risk factors for development of adult t-cell leukemia/lymphoma (atl) among human t-cell lymphotropic virus type-i (htlv-i) carriers. | 2002 | 12296513 |
| evaluation of anti-htlv-1 antibody in primary glomerulonephritis. | human t-cell leukaemia virus type-1 (htlv-1) is known to cause adult t-cell leukaemia. the prevalence of anti-htlv-1 antibody in haemodialysis patients has been reported to be higher than that in the general population. the anti-htlv-1 antibody-positive rate in patients with primary glomerulonephritis in the nagasaki district, an endemic area of htlv-1, was evaluated. the antibody-positive rates in patients with primary glomerulonephritis (9.9%) and in haemodialysis patients (18.4%) were signifi ... | 1995 | 7774759 |