| markers of health status in an htlv-i-positive cohort. | the health effects of chronic human t-cell lymphotropic virus type i (htlv-i) infection were examined in a cohort of japanese men who had emigrated from okinawa, japan, and had been participants in a prospective study in hawaii since 1965. in the present follow-up study carried out in 1987-1988, various health indicators were measured in the subjects, whose mean age was 72.5 years. participation rates were lower in the htlv-i seropositives than in the seronegatives (46.7% vs. 76.0%) in the > or ... | 1992 | 1488961 |
| modes of transmission and evidence for viral latency from studies of human t-cell lymphotrophic virus type i in japanese migrant populations in hawaii. | human t-cell lymphotrophic virus type i (htlv-i) seroprevalence was 20% among hawaiian japanese migrants (issei) and their offspring (nisei) from okinawa compared to 35% in similarly aged men who were lifetime residents of okinawa. a control group of migrants from a nonendemic area of japan, niigata, had low rates of htlv-i antibodies, suggesting that hawaii per se is not an endemic area for htlv-i. factors that were significantly associated with seropositivity in the okinawa migrant groups were ... | 1986 | 3014518 |
| prevalence of antibody to human t-cell lymphotropic virus type i in okinawa, japan, after an interval of 9 years. | to clarify events related to age dependence of human t-cell lymphotropic virus type i (htlv-i) seroprevalence, the authors carried out two seroepidemiologic studies at a 9-year interval on residents of yonaguni island, okinawa, japan. the overall prevalence was 17.8% (345/1,943) in 1980 and 17.1% (264/1,543) in 1989-1990. the authors studied the relation of the htlv-i infection rate to the birth year of 967 individuals tested in both years. of the 967 individuals, 209 were positive for anti-htlv ... | 1993 | 8434571 |
| low prevalence of human t cell lymphotropic virus type 1 infection in patients with gastric cancer. | there have been few studies on the association between human t cell lymphotropic virus type 1 (htlv-1) infection and cancer risk. it is still controversial whether or not htlv-1 infection affects the incidence of several cancers. with this background, we aimed to evaluate the relationship between htlv-1 infection and the occurrence of several types of cancers. | 2007 | 18031387 |
| lethal midline granuloma in okinawa with special emphasis on polymorphic reticulosis. | lethal midline granuloma (lmg) is a clinical term used to describe a condition which may be manifested histologically as wegener's granulomatosis (wg), polymorphic reticulosis (pr), and malignant lymphoma (ml). wg is an inflammatory disease, and pr and ml are considered to represent a neoplastic proliferation of lymphoreticular cells. in this report, twenty-two cases of lmg in okinawa were examined. the frequency of lmg per 100,000 outpatients of the ear, nose and throat clinic in okinawa was 67 ... | 1994 | 8200852 |
| a multicenter case-control study of htlv-i associated uveitis. study group for htlv-i associated ocular diseases. | to elucidate the epidemiology of human t-lymphotropic virus type i (htlv-i) associated uveitis (hau), a multicenter case-control study was carried out by the collaboration of university hospitals throughout kyushu and okinawa in southwestern japan where htlv-i is endemic; two institutions in the non-endemic metropolitan areas of tokyo and yokohama also participated. a total of 426 cases of endogenous uveitis were registered during the five-month period between september 1992 and january 1993; th ... | 1994 | 7967207 |
| the risk of human t cell leukemia virus and viral hepatitis infection among us marines stationed in okinawa, japan. | the prevalence and incidence of human t cell leukemia virus type i/ii (htlv-i/ii) and hepatitis a, b, and c virus infection were determined among us marines stationed in okinawa, japan. of 2875 personnel, 2 (0.07%) had antibody to htlv-i/ii. after 1-3 years, no htlv seroconversions were observed, although 23% reported sexual contact with okinawans. of 1010 hepatitis-tested marines, 121 (12%) had antibody to hepatitis a virus (anti-hav), 26 (2.6%) had antibody to hepatitis b core antigen (anti-hb ... | 1995 | 7876620 |
| screening for antibodies to human t-cell leukemia virus type i in japanese breast milk. | japanese breast milk samples were tested for antibodies to human t-cell leukemia virus type i (htlv-1) by particle agglutination (pa) and a line immunoassay (lia). in the pa method, the agglutination reaction between the htlv-1 antibody and sensitized particles occurred at a 1 : 128 dilution of some breast milk samples. the average antibody titer was one order of magnitude lower than that in the serum positive control. a total of 243 human breast milk specimens were assayed by pa, of which 21 sa ... | 2012 | 22687415 |
| human t-cell leukemia-lymphoma virus type 1 and adult t-cell leukemia-lymphoma in okinawa. | a serological survey for the presence of antibodies against the human t-cell leukemia virus, type 1 (htlv-1) in patients seen at the chubu hospital in okinawa was undertaken. all patients with the clinicopathological diagnosis of adult t-cell leukemia-lymphoma were positive. these cases had the characteristic features of adult t-cell leukemia-lymphoma: diffuse histology, often mixed cell or pleomorphic, and a high frequency of hypercalcemia, leukemic phase, diffuse visceral involvement, and oppo ... | 1985 | 2985255 |
| retrovirus-associated adult t-cell leukemia-lymphoma: an epidemiologic study of five cases among hawaii-born offspring of migrant japanese. | adult t-cell leukemia-lymphoma (atll) is a distinct clinicopathologic entity etiologically linked to htlv-i infection. we have identified five cases of retrovirus-associated atll among hawaii-born first generation offspring (nisei) of migrant japanese. four patients were offspring of migrant japanese (issei) who emigrated to hawaii from okinawa, an htlv-i endemic area. the fifth patient was born of parents who emigrated to hawaii from fukushima and miyagi prefectures, htlv-i nonendemic areas. ep ... | 1989 | 2921010 |
| prevalence of htlv-1 antibodies in hemodialysis patients in japan. | the southwestern region of japan is known as a very high endemic area of human t-cell lymphotropic virus type 1 (htlv-1), the etiologic agent for adult t-cell leukemia (atl) and probable causative agent for tropical spastic paraparesis and its japanese version, htlv-1-associated myelopathy (ham). hemodialysis (hd) patients seem to be at high risk for htlv-1 infection even in other regions of japan because they sometimes receive multiple blood transfusions. we examined antibody against atl-associ ... | 1988 | 2901222 |
| mother-to-child transmission of human t-cell leukemia virus type i (htlv-i): a fifteen-year follow-up study in okinawa, japan. | okinawa prefecture is one of the endemic areas for adult t-cell leukemia/lymphoma (atll) in japan. in this study, 2,013 serum specimens drawn serially over a period of 15 years (1968-1983) from 311 mother/child pairs in okinawa were tested for antibodies to human t-cell leukemia virus type i (htlv-i) by enzyme-linked immunosorbent assay and by indirect immunofluorescence. the prevalence rate of htlv-i antibodies was 20.9% (65 cases) in the mothers and 3.2% (10 cases) in the children. of the 65 s ... | 1987 | 2891625 |
| study of seroconversion of antibody to human t-cell lymphotropic virus type-i in children of okinawa, japan. | from 1983 to 1986, 1,813 children in nursery schools in ishigaki island and 1,228 children under 15 years old in the rural area in the yaeyama district of okinawa, japan, were tested for anti-htlv-i; 18 children (1.0%) in ishigaki island and 39 children (3.2%) in the rural area were positive. in order to survey when anti-htlv-i developed in these children, their older serum samples were investigated retrospectively for 1 to 5 years. two cases of seroconversion from anti-htlv-i negative to positi ... | 1990 | 2352497 |
| declining seroprevalence and transmission of htlv-i in japanese families who immigrated to hawaii. | this study examined the seroprevalence and transmission of human t cell lymphotropic virus type i (htlv-i) in japanese families who originated in okinawa, an area in which htlv-i is endemic, and who were currently residing in hawaii, a nonendemic area. among a cohort of japanese men whose sera were collected in hawaii in 1967-1975, those of okinawan ancestry had an htlv-i seroprevalence of 11.4%. this study, conducted in 1987-1988, sampled 142 index subjects from this male cohort and tested them ... | 1991 | 1951296 |
| epidemiological aspects of strongyloides stercoralis infection in okinawa, japan. | the epidemiology of strongyloides stercoralis infection was compared among three localities with various prevalences of human t lymphotropic virus type 1 (htlv-1) infection in okinawa prefecture, japan, using agar-plate culture of faeces. the prevalence of s. stercoralis infection is much higher in gusukube, where htlv-1 infection is rare, than in yomitan, where this viral infection is common. in all localities the parasite prevalence is significantly higher in males than in females, whereas the ... | 1992 | 1597879 |
| perinatal viral infections. | among the torch agents, the occurrence of rubella and human t-lymphotropic virus type 1 (htlv-1) in japan were studied. rubella epidemics occurred throughout japan from 1964 to 1969 and from 1975 to 1979. low prevalences of crs were observed in northeastern japan, and high prevalences in southwestern japan, with the highest in okinawa. these conditions could be explained by the lower rate of rubella h1 antibody in the female population of southwestern japan. time of maternal rubella was in the g ... | 1992 | 1396225 |
| human t-lymphotropic virus type 1 (htlv-1) genetic typing in kakeroma island, an island at the crossroads of the ryukyuans and wajin in japan, providing further insights into the origin of the virus in japan. | peripheral blood samples were collected from 23 human t-lymphotropic virus type-1 (htlv-1) carriers residing in kakeroma island, japan (kagoshima prefecture, oshima county, setouchi town), one of the most highly endemic areas in japan. the samples were subjected to amplification by pcr and sequencing of the long terminal repeat in order to reconstruct a phylogenetic tree of htlv-1 isolates. restriction fragment length polymorphism (rflp) analysis of env region was also conducted for subgrouping ... | 2009 | 19551824 |
| factors predisposing to htlv-1 infection in residents of the greater tokyo area. | human t-cell leukemia virus type 1 (htlv-1) is the etiological agent for adult t-cell leukemia. the geographic distribution of htlv-1 carriers is quite uneven in japan and the greatest prevalence is in southwestern japan. because many people move from endemic areas to the greater tokyo area, the geographic distribution might have changed. therefore, we investigated the factors predisposing to htlv-1 infection, including birthplace, for 88 htlv-1-infected individuals in greater tokyo who visited ... | 2008 | 19034610 |
| distribution of malignant lymphoma in japan: analysis of 2260 cases, 2001-2006. | the world health organization classification was used to conduct an analysis of geographic, age, sex, and lesion primarily biopsied/resected distribution of 2260 lymphoid neoplasms diagnosed during 2001-2006 throughout japan. b-cell neoplasms accounted for 65% of all lymphoid neoplasms, t/natural killer (t/nk)-cell neoplasms for 25% and hodgkin lymphoma for 7%. the most common type was diffuse large b-cell lymphoma (dlbcl, 33%), followed by follicular lymphoma (18%), and adult t-cell leukemia/ly ... | 2008 | 18251781 |
| association between strongyloides stercoralis infection and biliary tract cancer. | infectious agents, including parasites, often have oncogenic potential. however, there has been no study on the association between strongyloides stercoralis infection and cancer risk. therefore, we investigated the relationship between s. stercoralis infection and the occurrence of hepato-pancreato-biliary cancer. this case-control study examined 1,654 patients aged>or=50 years in the department of medicine and therapeutics, ryukyu university hospital, okinawa, japan, between 1991 and 2005. the ... | 2007 | 17611780 |
| why is the distribution of htlv-i carriers geographically biased? an answer through a mathematical epidemic model. | human t-cell leukemia virus type i (htlv-i) is a retrovirus that causes adult t-cell leukemia, and the distribution of htlv-i carriers is endemically biased, e.g. in japan the density of carriers is high in kyushu and okinawa. in order to consider population dynamics over long times taking account of an increase and a decrease of a population we propose a continuous-time htlv-i model. the model describes population dynamics of carrier numbers and that of carrier proportions, and theoretical resu ... | 2007 | 17132683 |
| impairment of host immune response against strongyloides stercoralis by human t cell lymphotropic virus type 1 infection. | a large-scale study was undertaken to clarify the prevalence rate of strongyloidiasis in okinawa, japan and to evaluate the relationship between strongyloidiasis and infection with human t cell lymphotropic virus type 1 (htlv-1). the prevalence rate of strongyloides stercoralis and htlv-1 infection were 6.3% and 14.0%, respectively. among 2,185 patients more than 50 years of age, the rate of s. stercoralis infection was significantly higher in patients with htlv-1 infection compared with patient ... | 2006 | 16474078 |
| a decrease in mother-to-child transmission of human t lymphotropic virus type i (htlv-i) in okinawa, japan. | to investigate the chronologic change of mother-to-child transmission of human t lymphotropic virus type i (htlv-i) in okinawa, japan, the presence of antibody to htlv-i was tested in 4,187 healthy residents between, 4,528 nursery school children, and 3,837 pregnant women between 1968 and 2000. the chronologic change of the feeding method and the length of the breast-feeding period among 1,117 healthy mothers from 1937 to 1995 were also obtained by interview. age-adjusted prevalence of htlv-i am ... | 2004 | 14993627 |
| increased risk of human herpesvirus-8 infection in patients with adult t cell leukemia/lymphoma in okinawa. | | 2002 | 12200715 |
| molecular epidemiology of human t lymphotropic virus type 1 transmission in okinawa, japan. | to clarify the route of human t lymphotropic virus type 1 (htlv-1) transmission, we sequenced three proviral genome regions (gag, env, int) of htlv-1 from 18 carriers in 7 families in okinawa, japan and compared the strains with isolates from other countries. the nucleotide substitution frequency among sequences derived from a single carrier was low; 0-0.24% in gag, 0-0.54% in env, and 0-0.34% in int. all sequences showed the closest identity to the cosmopolitan strain, with differences of only ... | 2002 | 12164296 |
| detection of epstein-barr virus and human t-cell lymphotropic virus type 1 in malignant nodal lymphoma, studied in okinawa, a subtropical area in japan. | formalin-fixed paraffin-embedded lymph node samples were collected from 100 cases of malignant nodal lymphoma documented in okinawa in the period from 1973 through 1998. according to the new world health organization classification, 12 cases were hodgkin's lymphoma (hl). eighty-eight cases of non-hodgkin's lymphoma (nhl) included 54 cases of t-cell type and 34 cases of b-cell type. using polymerase chain reaction (pcr), epstein-barr virus (ebv) was detected in 11 cases (91.7%) of hl and in 57 ca ... | 2002 | 11843296 |
| non-hodgkin's lymphoma of waldeyer's ring as a manifestation of lymphoproliferative diseases associated with human t-cell leukemia virus type 1 in southwestern japan. | adult t-cell leukemia/lymphoma (atl) usually presents with node- and/or cutaneous-based diseases, with a leukemic picture. it is not clear whether atl initially manifests with lesions in waldeyer's ring (wr) in an atl-endemic area. in the present study, we examined distributions of immunophenotypes and the presence of human t-cell leukemia virus type 1 (htlv-1) and epstein-barr virus (ebv) genomes in 62 cases of non-hodgkin's lymphoma (nhl) of wr (nhl-wr) from two areas of japan: osaka, an atl-n ... | 1997 | 9310958 |
| correlation between human t cell lymphotropic virus type-1 and strongyloides stercoralis infections and serum immunoglobulin e responses in residents of okinawa, japan. | to clarify the relationship between strongyloides stercoralis, infection with human t cell lymphotropic virus type-1 (htlv-1), and serum immunoglobulin e (ige) levels, epidemiologic investigations of these two infections were conducted in inhabitants of okinawa, a subtropical zone in japan. blood and feces samples were taken from 1,347 healthy inhabitants (554 males and 793 females). antibody to htlv-1 was measured by particle agglutination, enzyme-linked immunosorbent assay, and western blottin ... | 1997 | 9063365 |
| mother-to-child transmission of human t-lymphotropic virus type i (htlv-i): an extended follow-up study on children between 18 and 22-24 years old in okinawa, japan. | the significant difference observed between the seroprevalence of htlv-i in adults and in children is as yet unexplained. to evaluate a hypothetical explanation of the existence of seroconversion cases of "seronegative carriers" for this phenomenon, 21 of 55 children who had been born to seropositive mothers and who remained seronegative until the age of 18 years were further followed up at the ages of 22 and/or 24 years. none of the 21 seronegative children born to seropositive mothers seroconv ... | 1993 | 8436432 |
| relationship among strongyloides stercoralis infection, human t-cell lymphotropic virus type 1 infection, and cancer: a 24-year cohort inpatient study in okinawa, japan. | this study evaluated the prevalence of strongyloides stercoralis infection and human t-cell lymphotropic virus type 1 (htlv-1) infection in the population. in addition, this study investigated the relationship between s. stercoralis infection or htlv-1 infection and a patient's risk of developing related cancers. this is a retrospective cohort study of 5,209 patients. the prevalence of s. stercoralis infection was 5.2% among all patients. the prevalence among men (6.3%) was significantly higher ... | 2016 | 26621566 |
| epstein-barr virus in patients with polymorphic reticulosis (lethal midline granuloma) from china and japan. | polymorphic reticulosis is one of several diseases constituting lethal midline granuloma (lmg). previous immunohistochemical studies suggested a t-cell nature of proliferating cells; the term nasal t-cell lymphoma (ntl-lmg) has since been used widely. the authors' previous study in asian countries showed the clustering of mongolian patients with ntl-lmg, but the frequency varied with geographic area; it was much higher in korea and southwest japan (okinawa) than in shanghai and honshu, japan. re ... | 1994 | 8200002 |
| the incidence of adult t-cell leukemia/lymphoma among human t-lymphotropic virus type 1 carriers in japan. | human t-lymphotropic virus type 1 (htlv-1) is highly endemic in the kyushu/okinawa region of japan. a nationwide investigation verified the frequency of htlv-1 carriers among first-time blood donors and the occurrence of newly diagnosed adult t-cell leukemia/lymphoma (atl) cases from 2007 through 2008. after adjusting for differences in capture rate between areas, the age-, sex- and area-specific incidence of atl among carriers was determined. annual atl incidence among 10 000 carriers was 7.7 a ... | 2015 | 25219595 |