| molecular characterization of human t-lymphotropic virus, type 1 (htlv-1) found in kuwait: close similarity with htlv-1 isolates originating from mashhad, iran. | human t-lymphotropic virus, type 1 (htlv-1) infection was detected in two unrelated kuwaiti patients with tropical spastic paraparesis (ham/tsp) and in the asymptomatic mother of one of them. the family roots of these patients were traced to the najaf region of iraq. the dna sequence of three pcr-amplified fragments (env, 512 bp; pol, 140 bp; ltr, 704 bp) was determined for each of kuwaiti htlv-1 isolates (kuw-1,2,3). all three kuwaiti htlv-1 were identical in env and pol fragments and virtually ... | 1995 | 8573383 |
| common origin of human t-lymphotropic virus type-i from iran, kuwait, israel, and la réunion island. | we found previously that kuwaiti htlv-i isolates had two nucleotide substitutions in the most frequently sequenced regions of htlv-i genome, namely: t-->c 4783 in the pol and t-->c 6569 the env genes. these substitutions were observed rarely in other htlv-i isolates and seemed to be good markers of the htlv-i lineage, the "epicentre" of which was located in mashhad, iran. to test this hypothesis we sequenced the fragments of htlv-i genome including sites 4783 and 6569 from seven isolates obtaine ... | 1997 | 9131461 |
| high prevalence of htlv-i infection in mashhad, northeast iran: a population-based seroepidemiology survey. | background: mashhad, in the northeast of iran has been suggested as an endemic area for human t cell lymphotropic virus type i (htlv-i) infection since 1996. objectives: we performed a community-based seroepidemiology study to examine the prevalence and risk factors for htlv-i infection in the city of mashhad. study design: between may and september 2009, overall 1678 subjects from all the 12 geographical area of mashhad were selected randomly by multistage cluster sampling for htlv antibody. th ... | 2011 | 21840754 |
| adult t-cell leukemia/lymphoma revealed by a surgically cured cardiac valve lymphomatous involvement in an iranian woman: clinical, immunopathological and viromolecular studies. | a 60-year-old woman from the town of mashhad in northeastern iran developed cardiac failure due to aortic and mitral regurgitations which needed cardiac valve replacement. histopathological study of the valves revealed a t-cell non-hodgkin's lymphoma. blood examination showed leukemic features with 32% of abnormal white blood cells. human t-cell leukemia/lymphoma virus type i (htlv-i) antibodies were present in the serum and the specific env htlv-i sequences were detected in the dna extracted fr ... | 1993 | 8231261 |
| differences in viral and host genetic risk factors for development of human t-cell lymphotropic virus type 1 (htlv-1)-associated myelopathy/tropical spastic paraparesis between iranian and japanese htlv-1-infected individuals. | human t-cell lymphotropic virus type 1 (htlv-1)-associated myelopathy/tropical spastic paraparesis (ham/tsp) is a neurological disease observed only in 1-2 % of infected individuals. htlv-1 provirus load, certain hla alleles and htlv-1 tax subgroups are reported to be associated with different levels of risk for ham/tsp in kagoshima, japan. here, it was determined whether these risk factors were also valid for htlv-1-infected individuals in mashhad in northeastern iran, another region of endemic ... | 2005 | 15722539 |
| ethnic cluster of htlv-i infection in israel among the mashhadi jewish population. | a high prevalence of human t-lymphotropic virus type i (htlv-i) infection among israeli jews was previously reported. in the present study, screening for htlv-i of israeli jews was expanded to 10 ethnic groups. htlv-i antibodies were tested by the particle agglutination assay, elisa, and by western blot as a confirmatory method. the htlv-i proviral genome was tested by nested pcr with tax primers (sk43/sk44 and tr101/tr102). the pcr tests were carried out in all seropositive subjects and the ser ... | 1998 | 9783697 |
| prognosis of htlv-1 positive renal transplant recipients in iran. | the human t lymphocyte virus-1 (htlv-1) is the responsible pathogen for diseases such as htlv-1 associated myelopathy (ham) and adult t-cell leukemia (atl). mashhad, in northeast iran, with high instances of this infection, has a noticeable number of infected renal failure patients. since immunosuppressive drugs might decrease the latency period of htlv-1 or increase its complications, the question arises whether htlv-1 positive renal failure patients are suitable candidates for kidney transplan ... | 2011 | 21743209 |
| molecular analysis of human t cell lymphotropic virus type 1 and 2 (htlv-1/2) seroindeterminate blood donors from northeast iran: evidence of proviral tax, env, and gag sequences. | human t cell lymphotropic virus type 1 and 2 (htlv-1/2) western blot indeterminate results are a problem for blood banks in endemic areas. to determine the prevalence of htlv-1/2 infection among indeterminate donors, we analyzed 130 cases from mashhad, an htlv-1/2 endemic area in northeast iran. the most frequent western blot bands were gd21 alone (37.2%) followed by rgp46-2 alone (32.1%). we further tested 40 available dna samples of these cases by pcr for viral sequences, tax, gag, and pol, an ... | 2010 | 20929385 |
| declining tendency of human t-cell leukaemia virus type i carrier rates among blood donors in mashhad, iran. | | 2009 | 19900093 |
| specific cutaneous manifestations in adult t-cell leukemia/lymphoma. | adult t-cell leukemia/lymphoma (atll) is an aggressive malignancy which may occur in individuals infected with human t-cell lymphotropic virus type-i (htlv-i). htlv-i is endemic in khorasan, with a frequency of 2.3% in the general population. as specific cutaneous manifestations of lymphoma may occur in a significant number of patients, we studied these manifestations in atll patients admitted to the hematology and dermatology departments of ghaem hospital, mashhad, iran, during 1995-2004. | 2008 | 18377598 |
| zidovudine and interferon-alpha treatment induces a high response rate and reduces htlv-1 proviral load and vegf plasma levels in patients with adult t-cell leukemia from north east iran. | human t-cell lymphotropic virus type i (htlv-i) associated adult t-cell leukemia/lymphoma (atll) is endemic in southern japan, the caribbean, intertropical africa, and brazil. recently north east iran, particularly the region of mashhad, has been recognized as a new endemic region. atll is an aggressive t-cell lymphoproliferative disorder. patients with atll have high plasma levels of vegf that induce angiogenesis. prognosis of atll remains poor because of immunosuppression and intrinsic resista ... | 2007 | 17325893 |
| prevalence of human t-lymphotropic virus type 1 among blood donors from mashhad, iran. | the city of mashhad is the capital of khorasan, the northeastern province of iran, which has been recognized as an area where human t-lymphotropic virus type 1 (htlv-1) infection is endemic. all serum samples from blood donors are routinely screened for htlv-1 by using enzyme-linked immunosorbent assay (elisa). in the present study, 28,926 donors (81.86% male and 18.14% female) with a mean age of 32 years (range, 18 to 65 years) were screened in a 6 months period (july to december 1999). of thes ... | 2003 | 12791885 |