| epstein-barr-specific iga in nasopharyngeal cancer. | | 1978 | 78104 |
| comparative studies on immunity to ebv-associated antigens in npc patients in north america, tunisia, france and hong kong. | this study compared the relative antibody titers to ebv-related antigens in patients with nasopharyngeal carcinoma (npc) and controls from a high-incidence (hong kong), an intermediate incidence (tunisia), and two low-incidence (france, north america) areas to determine which of several ebv antibodies best differentiated npc patients from controls. antibodies measured include anti-virus capsid antigen (vca), anti-early antigen (ea), anti-soluble antigen by complement-fixation (cf) and antibody-d ... | 1977 | 198381 |
| epstein-barr virus dna in nasopharyngeal carcinomas from chinese patients in hong kong. | to investigate the presence of epstein-barr virus (ebv) in cases of nasopharyngeal carcinoma (npc) in chinese patients living in hong kong. | 1992 | 1317885 |
| nasopharyngeal carcinoma (npc). | | 1972 | 4333791 |
| neutralizing ebv-specific iga in throat washings of nasopharyngeal carcinoma (npc) patients. | throat washings from 26 nasopharyngeal carcinoma (npc) patients from hong kong and tunisia were studied for the presence of transforming ebv. only six (23%) were found positive which led to the hypothesis of a neutralizing factor in such salivas. the search for ebv-specific antibodies showed that npc saliva contained neutralizing vca and ea iga (54 and 27% respectively) and vca and ea igg (73 and 54% respectively). both transforming and non-transforming throat washings contained virus particles ... | 1977 | 193801 |
| cold lymphocytotoxic antibodies in nasopharyngeal carcinoma. | sera from patients with nasopharyngeal carcinoma (npc), a disease associated with epstein-barr virus (ebv), were found to be cytotoxic at 15% degrees c in the presence of complement for a panel of human lymphocytes, with a higher frequency than those of matched controls. the cold lymphocytotoxic antibodies (lta) responsible for this activity have the same properties as those described in sera from individuals with acute viral infections. the frequency and geometric mean titres (gmt) of lta varie ... | 1977 | 192260 |
| sero-epidemiology of the epstein-barr virus: preliminary analysis of an international study - a review. | samples of chinese, indian, african and caucasian populations, randomly selected in hong kong, singapore, the west nile district of uganda, and nancy, france, were titrated for antibodies to ebv, viral capsid (vca) and complement-fixing soluble (cf/s) antigens. the age-specific prevalence of infection (as reflected by the proportion of vca-positive individuals) varied greatly up to the age of 10 years in the four populations studied, the west nile district of uganda being outstanding in having a ... | 1975 | 191375 |
| epidemiology of the epstein-barr virus infection and associated tumors in man. | | 1975 | 183674 |
| nasopharyngeal carcinoma. ix. antibodies to ebna and correlation with response to other ebv antigens in chinese patients. | ninety-five sera from chinese npc patients in different stages of the disease, 38 sera from chinese patients with other cancers, and 50 normal chinese sera, were titrated for ebna, vca, ea and complement-fixing (cf/s) ebv-specific antibodies. the geometric mean (gmt) ebna antibody titre of patients with npc at stage i was found to be four times higher than that of normal individuals and increased in parallel with clinical deterioration. antibody titres against ebna did not correlate with either ... | 1975 | 171226 |
| prevalence of lmp1 deletion variant of epstein-barr virus in nasopharyngeal carcinoma and gastric tumors in hong kong. | | 1996 | 8647637 |
| absence of epstein-barr virus in penile carcinoma. a study of 42 cases using in situ hybridization. | the relationship between epstein-barr virus (ebv) and carcinomas of the lower female genital tract has been the focus of some studies in recent years. however, the association between ebv and penile carcinoma never has been investigated. the aim of this study was to identify the possible role of ebv in penile carcinoma of chinese patients. | 1995 | 8625161 |
| seroprevalence of antibodies to human herpesviruses in england and hong kong. | the age-related prevalence of antibodies to herpesviruses was compared in england and hong kong. altogether 327 sera from england and 266 sera from hong kong were tested for antibodies to herpes simplex virus (hsv), varicella-zoster virus (vzv), epstein-barr virus (ebv), cytomegalovirus (cmv), and human herpesvirus 6 (hhv-6). herpesvirus infections were common in both countries but generally were acquired earlier and were more prevalent in hong kong. over 90% of children in hong kong were infect ... | 1994 | 8083655 |
| detection of epstein-barr virus in hodgkin's disease occurring in an oriental population. | like burkitt's lymphoma, the strength of association of epstein-barr virus (ebv) with hodgkin's disease occurring in different populations and clinical settings is highly variable, being 30% to 50% in western countries, nearly 100% in third world countries like peru and honduras, and nearly 100% in patients seropositive for human immunodeficiency virus. data on the oriental populations are very limited. therefore, the current study was performed on the chinese population of hong kong, where the ... | 1995 | 7890284 |
| a study of the association of epstein-barr virus with burkitt's lymphoma occurring in a chinese population. | there is a strong association (approximately 95%) of endemic burkitt's lymphoma with epstein-barr virus (ebv), whereas the association is weak for the sporadic form occurring in western countries (approximately 15%). in the middle east, north africa and south america, 60-80% of burkitt's lymphomas harbour ebv. these epidemiological differences suggest that either the endemicity of ebv or socio-economic conditions, or both, may influence the pathogenetic role of ebv in burkitt's lymphoma. since o ... | 1995 | 7797201 |
| mutations clustered in exon 5 of the p53 gene in primary nasopharyngeal carcinomas from southeastern asia. | mutations in the p53 tumor suppressor gene play an important role in the development of many common human malignancies. in nasopharyngeal carcinomas (npc), p53 gene mutations were not detected in primary tumors, with one exception for a primary tumor displaying a p53 mutation at codon 280, whereas p53 mutations were identified in some metastatic and nude mouse-passaged npc specimens. in the present report, 41 npc primary tumors of the undifferentiated carcinoma nasopharyngeal type (ucnt; 21 from ... | 1995 | 7729941 |
| detection of epstein-barr viral rna in sinonasal undifferentiated carcinoma from western and asian patients. | undifferentiated carcinoma of the nasopharynx has a well-known association with epstein-barr virus (ebv), but only an inconsistent relationship has been identified in undifferentiated carcinomas occurring at other sites. we investigated 22 formalin-fixed, paraffin-embedded cases of sinonasal undifferentiated carcinomas (snucs) occurring in western and asian patients. a highly sensitive in situ hybridization method was performed using an antisense oligonucleotide probe to the eber1 gene of ebv. w ... | 1994 | 7511355 |
| nasopharyngeal carcinoma in american children: epstein-barr virus-specific antibody titers and prognosis. | seven american juvenile patients with undifferentiated or nonkeratinizing nasopharyngeal carcinoma (npc) were examined serially for epstein-barr virus (ebv)-specific antibody spectra and titers in sera. at diagnosis, all showed antibody patterns characteristic of npc: i.e., high titers of igg antibodies to viral capsid antigen (vca) and to the diffuse (d) component of the early antigen complex. six patients had iga antibodies to vca, and four to the d component. in the patients who responded to ... | 1982 | 6174465 |
| epstein-barr virus-associated antibody patterns in carcinoma of the post-nasal space. | | 1969 | 4902604 |
| seroepidemiological studies on nasopharyngeal carcinoma in china. | | 1985 | 2994402 |
| epstein-barr virus-associated gastric lymphoma in hong kong chinese. | we report 11 cases of gastric lymphoma that harbor the epstein-barr virus (ebv) encoded small messenger rna, eber-1, detected by in situ hybridization. the cases represented 18% of 61 consecutive gastric lymphomas from three institutions in hong kong between 1988 and 1993. the mean age of patients was 62 years (range, 33 to 87). the male to female ratio was 5:6. nine of the 11 (81.8%) eber-1+ gastric lymphomas were diffuse large cell lymphomas of b-cell type without low grade components. macrosc ... | 1994 | 8088772 |
| genetic polymorphism of natural epstein-barr virus isolates from infectious mononucleosis patients and healthy carriers. | we analyzed epstein-barr virus (ebv) genomes from lymphoblastoid cell lines isolated from patients with infectious mononucleosis and from healthy subjects from california, hawaii, and hong kong between 1970 and 1987. using genetic polymorphism as epidemiological markers, we found that several genotypes of ebv cocirculate in a community and that although most ebv strains isolated from california and southern china may be differentiated genotypically, there was no specific association between geno ... | 1988 | 2901499 |
| epstein-barr virus infections among university students in a tropical country. | | 1988 | 2846671 |
| lymphoepithelial carcinoma of the salivary gland: in situ detection of epstein-barr virus. | to examine the role of epstein-barr virus (ebv) in lymphoepithelial carcinoma of the salivary gland in hong kong chinese. | 1995 | 8543624 |
| direct detection of epstein-barr virus in peripheral blood and comparison of epstein-barr virus genotypes present in direct specimens and lymphoblastoid cell lines established from nasopharyngeal carcinoma patients and healthy carriers in hong kong. | by means of a pcr assay, ebv was demonstrated directly in peripheral blood of previously infected individuals. the virus was detected in approximately 80% of specimens from ebv-seropositive individuals, but not in cord-blood lymphocytes by this method. when virus present in peripheral blood was compared to that observed directly in npc biopsies or throat washings, it was distinct from that seen in biopsies in 4/15 cases (27%) and from that seen in throat washes in 1/22 cases (5%). the throat-was ... | 1992 | 1325949 |
| p53 mutation in human nasopharyngeal carcinomas. | nasopharyngeal carcinoma (npc) is the third most common cancer in the southern provinces of china, but a rare cancer in other parts of the world. epidemiological studies suggested a multifactorial etiology of npc involving infection of epstein barr virus (ebv), genetic predisposition, environmental factors, such as consumption of salted fish, and other unknown factors. p53 mutation is a common event in many forms of human cancers but its possible involvement in the pathogenesis of npc has not be ... | 1992 | 1295443 |
| epstein-barr virus-associated infectious mononucleosis in chinese children. | according to seroprevalence studies the majority of children in hong kong are infected by epstein-barr virus (ebv) before 10 years of age, but the characteristics of ebv-associated infectious mononucleosis (im) in chinese children are largely unreported. this study aims at defining the clinical presentation and complications of chinese childhood im in relation to age of the children. | 2003 | 14614370 |
| lymphoepithelioma-like carcinoma of oral cavity: report of three cases and literature review. | lymphoepithelioma-like carcinoma is a rare tumour in the oral cavity and is characterized histologically by non-keratinizing, undifferentiated squamous cell carcinoma with lymphocytic infiltration. three consecutive cases of intraoral lymphoepithelioma-like carcinoma are reported. a review of the literature reveals a similar biological behaviour to that of nasopharyngeal lymphoepithelioma: a high incidence of cervical nodal spread and remarkable radiosensitivity. chemotherapy should be considere ... | 2002 | 12102423 |
| a prospective study of primary epstein-barr virus infections among university students in hong kong. | in 1988 at the chinese university of hong kong 1,039 entering freshmen were screened for antibody against the epstein-barr virus and 71 (6.8%) were negative. one year later, 16 (25.8%) of 62 negatives converted to positive with asymptomatic infections. there was seroconversion in 14 subjects who did not give histories of deep kissing. there was an association between antibody status of epstein-barr and cytomegaloviruses, but not between epstein-barr virus and human herpes virus type 6. | 1990 | 2158753 |
| the detection of clinically occult nasopharyngeal carcinoma in patients following radiotherapy--an analysis of 69 patients. | a prospective analysis of 69 patients who had been treated for nasopharyngeal carcinoma (npc) by external radiotherapy was carried out. biopsies from the posterior nasopharynx were performed and analyzed by in situ hybridization using an antisense epstein-barr early rna (eber) radio-labelled riboprobe. none of the patients had evidence of disease in the nasopharynx. one patient was found to have nasopharyngeal carcinoma detected only by in situ hybridization. in the subsequent 18-month follow-up ... | 1996 | 8762329 |
| a study of the possible etiologic association of epstein-barr virus with reactive hemophagocytic syndrome in hong kong chinese. | the herpes group of viruses, particularly epstein-barr virus (ebv), has frequently been implicated in the causation of reactive hemophagocytic syndrome (rhs) in the western populations. ebv has also been implicated in the rare fulminant form of rhs occurring in oriental children. however, our previous adult-predominant study indicated little clinical and serological evidence of ebv infection in patients with rhs in hong kong. in the present study, we further examined this issue using a more sens ... | 1996 | 8912837 |
| nonnasal lymphoma expressing the natural killer cell marker cd56: a clinicopathologic study of 49 cases of an uncommon aggressive neoplasm. | expression of the natural killer (nk) cell antigen cd56 is uncommon among lymphomas, and those that do are almost exclusively of non-b-cell lineage and show a predilection for the nasal and nasopharyngeal region. this study analyzes 49 cases of nonnasal cd56+ lymphomas, the largest series to date, to characterize the clinicopathologic spectrum of these rare neoplasms. all patients were chinese. four categories could be delineated. (1) nasal-type nk/t cell lymphoma (n = 34) patients were adults 2 ... | 1997 | 9192774 |
| differences in ebv antibody titres of patients with nasopharyngeal carcinoma originating from high, intermediate and low incidence areas. | in order to assess the differences in serological reactivities of npc patients from high, intermediate and low incidence areas, 288 npc sera from hong kong, singapore, tunis, east africa, paris and los angeles, together with sera from patients with ear, nose and throat tumours other than npc and with those from normal individuals from the same areas, were tested 'blind' with the same batches of antigen. important differences (up to 3-fold) in the gmts of antibodies directed against vca, ea and e ... | 1978 | 215529 |
| specific latent membrane protein 1 gene sequences in type 1 and type 2 epstein-barr virus from nasopharyngeal carcinoma in hong kong. | we reported previously that a characteristic epstein-barr virus latent membrane protein 1 (ebv-lmp1) gene was associated with nasopharyngeal carcinoma (npc) in hong kong. it showed a 30 bp deletion at the carboxyl terminus with specific amino acid substitution asp at codon 335 with reference to gly in b95-8 lmp1. this deletion variant asp335 was present in over 90% of npc biopsy specimens. the present study attempted to determine the whole encoding sequence of the lmp1 gene in different ebv isol ... | 1998 | 9579578 |
| nasopharyngeal carcinoma research in hong kong in the past decade. | to review the research carried out in hong kong on nasopharyngeal carcinoma (npc) over the past 10 years. | 1997 | 9772411 |
| descriptive and analytical epidemiology of nasopharyngeal cancer. | information concerning the descriptive and analytical epidemiology of npc that has been reported mainly since the first international symposium on the subject in singapore in 1964 are reviewed. npc is rare in most countries in the world, with an age-adjusted incidence rate of less than 1 per 100,000, and the incidence rate is twice as high in males as in females. chinese of southern origin have a uniquely high risk, the incidence rates per 100,000 being 10--20 in males and 5--10 in females. the ... | 1978 | 215514 |
| autoantibodies (cold lymphocytotoxins, antiactin antibodies and antinuclear factors) in nasopharyngeal carcinoma patients. | lta, sma and ana were found at higher frequencies in sera from npc patients than in those from matched controls. the frequency and gmts of lta-positive sera varied with the origin of the patient (chinese greater than north african greater than caucasian, thus paralleling the risk for npc in each ethnic group) and the stage of the disease (stage iv greater than stage i). a positive correlation was found between lta and anti-ebv titres with regard to anti-vca and anti-ebna antibodies. sma were spe ... | 1978 | 215532 |
| association of pure red cell aplasia with t large granular lymphocyte leukaemia. | to define the relation between t large granular lymphocyte (t-lgl) leukaemia and pure red cell aplasia in chinese patients. | 1998 | 9930071 |
| incidence and pathology of primary brain lymphoma in hong kong chinese patients. | primary brain lymphoma (pbl) is an uncommon extranodal lymphoma. its incidence is rapidly increasing in both immunocompromised and immunocompetent patients in western countries. eighteen cases of pbl were identified during a 16-year period among hiv negative patients in queen mary hospital, hong kong. one case of post-transplantation lymphoproliferative disease (ptld) was positive for epstein barr virus (ebv) encoded rna (eber) by in situ hybridization. all the remaining 17 immunocompetent cases ... | 2000 | 10721783 |
| microsatellite instability, epstein-barr virus, mutation of type ii transforming growth factor beta receptor and bax in gastric carcinomas in hong kong chinese. | microsatellite instability (mi), the phenotypic manifestation of mismatch repair failure, is found in a proportion of gastric carcinomas. little is known of the links between mi and epstein-barr virus (ebv) status and clinicopathological elements. examination of genes mutated through the mi mechanism could also be expected to reveal important information on the carcinogenic pathway. seventy-nine gastric carcinomas (61 ebv negative, 18 ebv positive) from local hong kong chinese population, an int ... | 1999 | 10027334 |
| the association of squamous cell carcinomas of the nasopharynx with epstein-barr virus shows geographical variation reminiscent of burkitt's lymphoma. | nasopharyngeal carcinoma (npc) is rare in most parts of the world but occurs with high incidence in certain regions, such as south-east asia. two major histological types of npc are recognized, non-keratinizing carcinoma and squamous cell carcinoma. non-keratinizing npcs, which include undifferentiated npc, are invariably associated with epstein-barr virus (ebv) infection, regardless of the geographical or ethnic origin of the patients. by contrast, conflicting results have been published concer ... | 1997 | 9390028 |
| clinical profiles of human immunodeficiency virus-associated lymphoma in hong kong. | to identify the clinical and prognostic features of human immunodeficiency virus-associated lymphoma in the local population with a view to designing more effective treatment strategies. | 2003 | 12668818 |
| ebv specific antibody-based and dna-based assays in serologic diagnosis of nasopharyngeal carcinoma. | we assessed 5 ebv specific assays for their capacity to effect serologic diagnosis of suspected npc. the assays were the immunofluorescent assays, vca iga and ea iga, the enzyme-linked immunosorbent assays specific for ebna 1 iga or zta igg and an ebv dna assay. serum samples were taken from 218 symptomatic npc patients presenting consecutively at a public hospital in hong kong, 51 of whom were subsequently diagnosed as having npc; 4 had ebv-associated lung cancer with similar serology as npc. t ... | 2003 | 12740922 |
| skin metastasis from nasopharyngeal carcinoma in four chinese patients. | nasopharyngeal carcinoma (npc) is a common malignancy among southern chinese. the tumours are mostly undifferentiated carcinomas and are associated with epstein-barr virus. patients present with a blood-stained postnasal discharge, impaired hearing, tinnitus or cervical lymph node enlargement. radiotherapy with or without chemotherapy is the standard treatment. though metastatic lung, bone or liver disease is not uncommon on relapse, skin metastasis is rarely reported. the small number of report ... | 2004 | 14723715 |
| identification of serum amyloid a protein as a potentially useful biomarker to monitor relapse of nasopharyngeal cancer by serum proteomic profiling. | nasopharyngeal cancer (npc) is a common cancer in hong kong, and relapse can occur frequently. using protein chip profiling analysis, we aimed to identify serum biomarkers that were useful in the diagnosis of relapse in npc. experimental design: profiling analysis was performed on 704 sera collected from 42 npc patients, 39 lung cancer patients, 30 patients with the benign metabolic disorder thyrotoxicosis (tx), and 35 normal individuals (nm). protein profile in each npc patient during clinical ... | 2004 | 14734450 |
| phenotypic alterations induced by the hong kong-prevalent epstein-barr virus-encoded lmp1 variant (2117-lmp1) in nasopharyngeal epithelial cells. | epstein-barr virus (ebv) is closely associated with nasopharyngeal carcinoma (npc), a common cancer in hong kong. the ebv-encoded lmp1 protein is believed to play an important role in cell transformation. we have previously identified a prevalent lmp1 variant (2117-lmp1) that is expressed in 86% of primary npc in hong kong. in this study, the biologic phenotypes induced by 2117-lmp1 were compared with those of the prototypic b95.8-lmp1 in an immortalized nasopharyngeal epithelial cell line, np69 ... | 2004 | 15027126 |
| epstein-barr virus (ebv) infection in infancy. | epstein-barr virus (ebv) has been shown to be the cause of infectious mononucleosis (im) and has more complicated associations with several malignant diseases. these ebv associated diseases provide a strong incentive for the development of an ebv vaccine. most primary ebv infection during infancy and early childhood is mild or subclinical. little is known about its infection in infancy. the pattern of ebv serological response during infancy may be important for vaccine management. | 2001 | 11255098 |
| molecular diversity of epstein-barr virus igg and iga antibody responses in nasopharyngeal carcinoma: a comparison of indonesian, chinese, and european subjects. | epstein-barr virus (ebv)-specific immunoblot analysis was used to reveal the molecular diversity of immunoglobulin (ig) g and iga antibody responses against epstein-barr nuclear antigen (ebna), early antigen (ea), and viral capsid antigen (vca) in serum samples from patients with nasopharyngeal carcinoma (npc) and control subjects, by use of immunofluorescence assay (ifa). control donors (n=150) showed igg responses to few ebv proteins--vca-p18, vca-p40, ebna1, and zebra--and sporadically weak i ... | 2004 | 15195243 |
| outcome of patients with positive epstein-barr virus serologic status in the absence of nasopharyngeal carcinoma in hong kong. | to evaluate the current clinical practice of follow-up and the outcomes of patients with raised epstein-barr virus (ebv) antibody levels but without pathological evidence of nasopharyngeal carcinoma (npc) for a possible risk of developing npc in the future. | 2004 | 15210561 |
| antibodies to epstein-barr virus in nasopharyngeal carcinoma, other head and neck neoplasms, and control groups. | | 1970 | 11515035 |
| distinct epidermal growth factor receptor and kras mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features. | this study evaluated the mutational profile of epidermal growth factor receptor (egfr) and kras in non-small cell lung cancers in hong kong and determined their relation with smoking history and other clinicopathologic features. | 2006 | 16533793 |
| incidence rate trends of histological subtypes of nasopharyngeal carcinoma in hong kong. | the overall decline in incidence rate of nasopharyngeal carcinoma in hong kong during 1988-2002 was limited primarily to a decrease in keratinising carcinoma, which could be explained by the decline in cigarette smoking. genetic and epstein-barr virus interactions may explain the relatively stable incidence rate of non-keratinising carcinoma. | 2006 | 17031401 |
| evaluation of screening for nasopharyngeal carcinoma: trial design using markov chain models. | in this paper, we develop a markov chain model to estimate parameters pertaining to the natural history of nasopharyngeal carcinoma (npc). the model is of progression from no disease to epstein-barr virus (ebv) infection, preclinical screen-detectable tumour and clinical tumour. we derive tentative estimates of the parameters of the model, based on limited published data, to assess the efficacy of serum screening in conjunction with clinical assessment (indirect mirror examination for npc), for ... | 1999 | 10206310 |
| pathogenesis of gastric lymphoma: the enigma in hong kong. | helicobacter pylori (h. pylori) infection has been postulated to be a pathogenetic factor in gastric lymphoma. however, the etiological factors for gastric lymphoma could vary in different populations. | 1997 | 9209639 |
| screening for family members of patients with nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is well known for its peculiarly skewed distribution with highest incidence in southern chinese population. familial aggregation is evident, hence screening for early detection is offered by oncology centers in hong kong to first-degree relatives of patients with npc. during the period 1994-2001, 929 family members were screened in our center. the screenees were advised to attend an annual examination that includes serological test against epstein barr virus (ebv), ... | 2005 | 15515016 |
| the prognostic significance of tumor vascular invasion and its association with plasma epstein-barr virus dna, tumor volume and metabolic activity in locoregionally advanced nasopharyngeal carcinoma. | parapharyngeal tumor invasion is a known predictor of distant recurrence in stage ii-iii nasopharyngeal carcinoma (npc). this study evaluated the prognostic significance of parapharyngeal and cavernous sinus vascular invasion in stage iii-iv npc, and its association with plasma epstein-barr virus (pebv) dna, disease stage, tumor volume and metabolic activity. eligible patients underwent magnetic resonance imaging (mri), 18f-fluorodeoxyglucose (fdg)-positron-emission tomography (pet) and blood sa ... | 2008 | 18396444 |
| epstein-barr virus latent membrane protein 1 (lmp1) upregulates id1 expression in nasopharyngeal epithelial cells. | nasopharyngeal carcinoma is closely associated with epstein-barr virus (ebv) infection. the ebv-encoded lmp1 has cell transformation property. it suppresses cellular senescence and enhances cell survival in various cell types. many of the downstream events of lmp1 expression are mediated through its ability to activate nf-kappab. in this study, we report a novel function of lmp1 to induce id1 expression in nasopharyngeal epithelial cells (np69) and human embryonal kidney cells (hek293). the id1 ... | 2004 | 15064751 |
| lymphoepithelioma-like hepatocellular carcinoma: an uncommon variant of hepatocellular carcinoma with favorable outcome. | lymphoepithelioma-like hepatocellular carcinoma (lel-hcc) is an uncommon variant of hcc with only 22 cases reported in the literature. to better determine the incidence, clinicopathologic features, prognostic significance, and molecular pathogenesis of lel-hcc, we presented the largest series of lel-hcc from a 9-year retrospective cohort of patients with hcc undergoing surgical resection. lel-hcc was identified in 20 patients (4.9%). compared with patients having hcc without significant tumor-in ... | 2015 | 25675010 |
| salivary epstein-barr virus dna level in patients with nasopharyngeal carcinoma following radiotherapy. | nasopharyngeal carcinoma (npc) is a solid tumor closely associated with epstein-barr virus (ebv) infection. the purpose of this investigation was to detect and quantify the ebv dna level in salivary samples of npc patients following treatment using real-time pcr. a total of 175 consecutive newly diagnosed npc patients' whole saliva samples were collected before treatment, and the ebv dna level was measured by real-time pcr, with the primers and probe targeting the bamhi-w region of the ebv genom ... | 2011 | 21767975 |
| risk stratification on the basis of deauville score on pet-ct and the presence of epstein-barr virus dna after completion of primary treatment for extranodal natural killer/t-cell lymphoma, nasal type: a multicentre, retrospective analysis. | assessment of tumour viability after treatment is essential for prediction of treatment failure in patients with extranodal natural killer/t-cell lymphoma (enktl). we aimed to assess the use of the post-treatment deauville score on pet-ct and epstein-barr virus dna as a predictor of residual tumour, to establish the risk of treatment failure in patients with newly diagnosed enktl. | 2015 | 26687611 |
| prevalence of human papillomavirus, epstein-barr virus, p21, and p53 expression in sinonasal inverted papilloma, nasal polyp, and hypertrophied turbinate in hong kong patients. | background: the purpose of this study of human papillomavirus (hpv), epstein-barr virus (ebv), p21, and p53 in sinonasal inverted papilloma (ip) was to help elucidate its pathogenesis. methods: seventy-three ips, 48 nasal polyps, and 85 hypertrophied turbinates were subjected to hpv polymerase chain reaction (pcr) study. seventy-three ips, 30 nasal polyps, and 32 hypertrophied turbinates were subjected to ebv in situ hybridization (ish), p21, and p53 immunohistochemical (ihc) studies. results: h ... | 2011 | 21608063 |
| prevalence of mutations and 30-bp deletion in the c-terminal region of epstein-barr virus latent membrane protein-1 oncogene in reactive lymphoid tissue and non-nasopharyngeal ebv-associated carcinomas in hong kong chinese. | a specific variant of epstein-barr virus (ebv) with a 30-bp deletion in the c-terminal region of the lmp1 gene has been found in some ebv-associated malignancies. to better understand the tumorigenic role of this lmp1 variant, we used pcr and sequencing to examine the lmp1 gene in 38 ebv-associated carcinomas (ebv-cas) occurring in various organs (6 lung, 10 salivary gland, 5 sino-nasal, 16 gastric and 1 metastatic npc), 55 reactive lymphoid tissues from tonsils (ton) and 67 ebv-negative tumours ... | 1997 | 9219824 |
| outcomes of nasopharyngeal carcinoma screening for high risk family members in hong kong. | we undertook a large retrospective study to evaluate the impact of screening family members of npc patients with epstein barr virus (ebv) serology. 1,199 asymptomatic family members of npc patients were entered into the annual screening program with ebv serology and nasopharyngoscopy between 1994 and 2005. eighteen participants of our screening program developed npc; 17 of them were treated in our institute, of whom 16 were detected in screening. the sensitivity and specificity of ebv serology w ... | 2010 | 19779847 |
| type ii enteropathy-associated t-cell lymphoma: a multicenter analysis from the asia lymphoma study group. | enteropathy-associated t-cell lymphoma (eatl) is a rare primary gastrointestinal t-cell lymphoma. a multicenter study from the asia lymphoma study group identified 38 eatl patients within a 19-year period. all cases were type ii eatl. men were affected twice as common as women, at a median age of 59 (23-89) years. none had a history of celiac disease. the sites of involvement were small bowel and stomach (5%), small bowel (63%), small and large bowel (16%), and large bowel (18%). common presenti ... | 2012 | 22641357 |