| differences in the growth pattern and clinical course of ebv-lmp1 expressing and non-expressing nasopharyngeal carcinomas. | all low differentiated or anaplastic forms of nasopharyngeal carcinoma (npc) carry multiple copies of ebv-dna and express ebna1. the major membrane protein, lmp1, is only expressed in 65% of the tumours. the physiological function of lmp1 in the viral life cycle is unknown, but it has been shown to transform established rodent fibroblasts and immortalised human keratinocytes in vitro, and to increase the likelihood of a malignant transformation. we studied 74 cases collected from the shanghai an ... | 1995 | 7640034 |
| epstein-barr virus in patients with polymorphic reticulosis (lethal midline granuloma) from china and japan. | polymorphic reticulosis is one of several diseases constituting lethal midline granuloma (lmg). previous immunohistochemical studies suggested a t-cell nature of proliferating cells; the term nasal t-cell lymphoma (ntl-lmg) has since been used widely. the authors' previous study in asian countries showed the clustering of mongolian patients with ntl-lmg, but the frequency varied with geographic area; it was much higher in korea and southwest japan (okinawa) than in shanghai and honshu, japan. re ... | 1994 | 8200002 |
| mutational events in lmp1 gene of epstein-barr virus in salivary gland lymphoepithelial carcinomas. | it is still unknown what kinds of roles epstein-barr virus (ebv) infection that are highly specific to salivary gland lymphoepithelial carcinomas (lecs) play in their tumorigenesis. to clarify the significance of ebv in lecs, we paid particular attention to the lmp1 gene, which is responsible for triggering several pathways for activating transcription factors. sixty-one cases of ebv positive lecs confirmed by pcr and in-situ hybridization were collected from various areas of the world and studi ... | 2003 | 12740914 |
| epstein-barr virus infected lymphoepithelial carcinomas of the salivary gland in the russia-asia area: a clinicopathologic study of 160 cases. | in order to determine the prevalence of the epstein-barr virus (ebv) infection in salivary gland lymphoepithelial carcinomas (lec), we have collected 160 cases from asian countries and russia. all the cases examined by pcr for ebv dna bamhi fragment and in-situ hybridization for eber-1, ebv encoded small rna, showed positivity for ebv infection in lec cells, while no positive signals were found in any other salivary neoplasm examined. the incidence of lec was highest in guanzhou, followed by sha ... | 2003 | 15357246 |
| analysis of clinical characteristics of 516 patients with non-hodgkin's lymphoma in shanghai area. | the aim was to determine the clinical and cytogenetic characteristics of non-hodgkin's lymphoma (nhl) in shanghai. a retrospective analysis was conducted in 516 patients with nhl. patient clinical data, including age, sex, diagnosis, immunophenotypes, and karyotypes, were collected. the median age was 58 years. there was a male predominance in all nhl, except extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue. patients with b cell nhl (1.5%) expressed cd3. t cell nhl patients ... | 2014 | 23795960 |
| differential prevalence and correlates of whole blood epstein-barr virus dna between hiv-positive and hiv-negative men who have sex with men in shanghai, china. | this cross-sectional study aimed to examine and compare prevalence and correlates of whole blood epstein-barr virus (ebv) dna between hiv-positive and hiv-negative men who have sex with men (msm). five hundred and four hiv-positive msm and 504 age-matched hiv-negative msm were recruited from an hiv counseling and testing clinic in shanghai, china from november 2014 to november 2015 and were administered with a face-to-face questionnaire interview. whole blood ebv dna was tested by nested polymer ... | 2017 | 28578749 |