| homology of epstein-barr virus dna in nasopharyngeal carcinomas from kenya, taiwan, singapore and tunisia. | | 1975 | 191360 |
| auto-antibodies in the sera of patients with nasopharyngeal carcinoma. | | 1975 | 191369 |
| antibodies to epstein-barr virus capsid antigen and early antigen in nasopharyngeal carcinoma and comparison groups. | antibodies to epstein-barr virus capsid antigen (anti-vca) and early antigen (anti-ea) were measured in 263 patients with nasopharyngeal carcinoma (npc), 624 age- and sex-matched neighborhood controls, 570 family members of npc patients and 830 family members of neighborhood controls in taiwan. the distribution of antibody titers was significantly different between npc patients and the other three groups. more than 55% and 45% of npc patients had titers of greater than or equal to 1:640 and grea ... | 1977 | 199059 |
| histopathological types of nasopharyngeal carcinoma in a low-risk area: japan. | npc in japan was studied histopathologically by examining 816 npcs from among 3 338 biopsies from patients with tumours of the nasopharynx and other parts of the upper respiratory system. in addition, a comparative study on npc among taiwanese and an immunoserological study were carried out. when comparing histological types of malignant tumours of the upper respiratory tract, poorly-differentiated squamous-cell carcinoma predominated only in those of the nasopharynx. malignant nasopharyngeal tu ... | 1978 | 215515 |
| interaction of factors associated with cancer of the nasopharynx. | a retrospective study of nasopharyngeal carcinoma (npc) revealed that smoking, working under poor ventilation, use of nasal balms or oil for nasal and throat troubles, use of herbal drugs, and anti-ebv antibody titer were found statistically associated. the dural interactions of these factors to the risk of npc were presented. except in work conditions with poor ventilation and when herbal drugs are used, all the combinations were synergistic. the synergistic actions were especially remarkable w ... | 1979 | 227565 |
| sequence analysis of the bzlf 1 gene of epstein-barr virus derived from a new variant isolated in taiwan. | | 1992 | 1310809 |
| distribution of type a and type b ebv in normal individuals and patients with head and neck carcinomas in taiwan. | the subtypes of epstein-barr virus (ebv) according to the ebna 2 gene were investigated in taiwan by the polymerase chain reaction (pcr) and by southern blot hybridization. the materials included 53 nasopharyngeal carcinoma (npc) biopsies, 49 other head and neck cancers and 32 throat washings of normal individuals. ebv dna was found in all npc biopsies, 27 of 49 other head and neck carcinomas and 81% of normal individuals. type a ebv was the predominant type of ebv in both normal individuals and ... | 1992 | 1322927 |
| fireside conference 16. nasopharyngeal carcinoma. | | 1992 | 1327018 |
| prevalence of antibody to epstein-barr virus dnase in children. | antibodies to epstein-barr-virus-specific dnase in children under 15 years old from taipei, taiwan were determined by an enzyme neutralization test. serum was taken as positive for the anti-dnase antibody when 1 ml of serum could neutralize > or = 2 units of the dnase activity. among the 1,292 sera tested, 5.6% of the children were shown to have anti-ebv dnase antibodies, a result similar to that for adults. maternal antibodies against the ebv dnase were found to decrease very rapidly 2 months a ... | 1992 | 1339186 |
| occurrence of nasopharyngeal carcinoma in aboriginals of taiwan: report of 14 cases. | the authors describe the rare occurrence of nasopharyngeal carcinoma (npc) in 14 aboriginals of taiwan (abt), a minor ethnic group now accounting for less than 2% of the total population in taiwan. the observation is epidemiologically unusual, representing a low-risk ethnic group in an npc prevalent area. with regard to patient characteristics, symptomatology and pathology, we have not found any appreciable differences in reports from other geographic areas. serological profiles of antiebv-vca ( ... | 1992 | 1363202 |
| a pathologic study of childhood lymphoma in taiwan with special reference to peripheral t-cell lymphoma and the association with epstein-barr viral infection. | the authors retrospectively reviewed the clinicopathologic and immunologic features of 65 consecutive cases of childhood lymphoma reported between 1980 and 1989. southern blot hybridization was also performed in 23 cases to study their association with epstein-barr virus (ebv) and human t-cell leukemia virus type 1 (htlv-1). the 65 cases included 56 non-hodgkin's lymphoma (nhl) (86%) and 9 hodgkin's disease (hd) (14%). the nhl could be classified into the following groups: group i, small nonclea ... | 1991 | 1655230 |
| nasopharyngeal carcinoma in young patients. | we have reviewed retrospectively the records of 157 patients, less than or equal to 30 years of age with nasopharyngeal carcinoma (npc) from 218 such cases identified in the tumor registry files of three major teaching hospitals in taipei, taiwan. these cases were diagnosed between 1 january 1982 and 31 december 1985, with a minimum follow-up of 2 years. the average age was 25, with a male/female ratio of 1.67. the tnm (tumor size, nodes, metastases) classification of 127 patients showed t1, 22% ... | 1991 | 1846256 |
| a prospective study of post-transfusion non-a, non-b (type c) hepatitis following cardiovascular surgery in taiwan. | in an attempt to investigate the incidence and clinical course of non-a, non-b (nanb) hepatitis following blood transfusion in taiwan, 288 patients who underwent cardiovascular surgery and received blood transfusion were followed prospectively with serum liver aminotransferase levels and viral hepatitis markers for at least six months. none had any past history of liver disease or drug abuse. all blood donors were tested for serum hepatitis b surface antigen and alanine aminotransferase (alt) (g ... | 1991 | 1908889 |
| fatal primary epstein-barr virus infection masquerading as histiocytic medullary reticulosis in young children in taiwan. | we reported 3 fatal cases of primary epstein-barr virus (ebv) infection resembling histiocytic medullary reticulosis (hmr) in young children in taiwan, where an hmr-like illness has been previously found to be prevalent. the disease ran a fulminant course, manifesting as fever, anemia, jaundice, skin rash, pulmonary infiltration, and/or hepatosplenomegaly lasting for only 1-3 weeks. laboratory tests revealed no hemolytic anemia and coombs test was negative. sepsis or hmr was the main clinical di ... | 1990 | 1963624 |
| antibody to epstein-barr virus-specific dnase as a marker for field survey of patients with nasopharyngeal carcinoma in taiwan. | a serological survey using antibody to epstein-barr virus (ebv)-specific dnase activity as a marker for the identification of patients with nasopharyngeal carcinoma (npc) has been carried out on healthy subjects who visited government employees' clinic center (gecc) for routine health examination and on individuals residing in npc high-risk areas (hra) in taiwan. during a 3-year prospective study, 22,596 and 9,869 sera were collected from the gecc and hra groups, respectively. taking neutralizat ... | 1989 | 2542436 |
| seroepidemiological study of epstein-barr virus infection in children in taipei. | serumigg antibody titer against viral capsid antigen(vca) of epstein-barr virus (ebv) was measured by indirect immunofluorescence antibody method in 1350 children under 15 years of age, 723 males and 627 females, who were living in the taipei area. sera were collected from june through october 1984. under the age of 6 months, the prevalence rate of positive serum vca antibody was 38.4%. it decreased to 6.4% between 6 and 12 months of age, but rose to 65.8% during the second year of life. the rat ... | 1989 | 2561579 |
| histiocytic medullary reticulosis: a lethal form of primary ebv infection in young children in taiwan. | | 1989 | 2563546 |
| antibodies to epstein-barr virus-specific dnase in patients with nasopharyngeal carcinoma and control groups. | serum samples from 154 patients with nasopharyngeal carcinoma (npc), 374 with other cancers, 1,000 normal controls from government employees' clinic center (gecc), and 3,642 individuals of various ethnic-dialect groups living in high-risk areas for npc were collected and the concentration of antibodies to epstein-barr virus (ebv)-specific dnase activity was determined. taking a serum sample where 1 ml will neutralize two or more units of the dnase activity as positive, 2-4 units as low level, 4- ... | 1987 | 2824675 |
| antibody response to epstein-barr-virus-specific dnase in 13 patients with nasopharyngeal carcinoma in taiwan: a retrospective study. | serum samples obtained from 13 individuals who were found to have a previous history of or to be suffering from nasopharyngeal carcinoma (npc) were examined for the presence of antibody to epstein-barr virus (ebv) dnase activity. significant to high levels of antibody to ebv dnase activity were detected in most serum samples obtained from four patients prior to the diagnosis of npc. the samples from the other nine patients showed variable levels of antibody. the majority of the samples collected ... | 1985 | 2989423 |
| antibody to epstein-barr virus-specific dnase as a marker for the early detection of nasopharyngeal carcinoma. | we have previously shown that high levels of antibody to epstein-barr virus (ebv)-specific dnase may be a useful marker for the early diagnosis of nasopharyngeal carcinoma (npc). sera from 3,368 males in an area with a high risk for the development of npc were examined for the presence of antibody to ebv-specific dnase activity. significant levels of the antibody were found in 430 of these sera. as a result, 32 individuals have attended the out-patient department of otolaryngology for clinical e ... | 1985 | 2995572 |
| antibodies to epstein-barr virus in a burkitt's lymphoma cell line in taiwan monkeys (macaca cyclopis). | the prevalence of taiwan monkeys with antibodies to epstein-barr virus, as detected by the indirect immunofluorescence technique, was lower than that of healthy persons in taiwan. | 1971 | 4324196 |
| [antinuclear antibody]. | | 1971 | 4326467 |
| antibodies to herpes-type virus in nasopharyngeal carcinoma and control groups. | | 1972 | 4334237 |
| seroepidemiological studies on carcinoma of the nasopharynx. | | 1973 | 4355974 |
| anti-epstein barr virus antibody in nasopharyngeal carcinoma. | | 1974 | 4359674 |
| detection of an epstein-barr-virus variant in t-cell-lymphoma tissues identical to the distinct strain observed in nasopharyngeal carcinoma in the taiwanese population. | an ebv variant has been identified in npc tissues in taiwan. this ebv variant contains a point mutation in exon i of the lmp i gene. this mutation results in the loss of an xhoi site at nt 169,426, which is present in strain b95-8. in addition, this variant contains a 30-bp deletion in exon 3 of the gene. the recent demonstration of the prevalence of ebv-containing nasal and peripheral t-cell lymphoma in this region drove us to evaluate the presence of this npc-ebv strain in 7 cases of t-cell ly ... | 1995 | 7558413 |
| hematophagic histiocytosis: a clinicopathologic analysis of 23 cases with special reference to the association with peripheral t-cell lymphoma. | the clinicopathologic features of 23 patients with hematophagic histiocytosis (hh) are described. all of them exhibited increased histiocytes associated with hemophagocytosis in the marrow. the patients usually presented with fever, hepatosplenomegaly, lymphadenopathy, and cytopenia. the underlying illnesses were heterogeneous, including non-hodgkin's lymphoma in 17, systemic lupus erythematosus in one, diabetes mellitus in one, acute myelomonocytic leukemia in one, myelodysplastic syndrome in o ... | 1994 | 7920083 |
| prevalence of taiwan variant of epstein-barr virus in throat washings from patients with head and neck tumors in taiwan. | the prevalence of the epstein-barr virus (ebv) taiwan variant was investigated in the throat washing (tw) samples from patients with head and neck tumors, persons with nonmalignant diseases, and healthy adults in taiwan. by using the ebv (bnlf-1 gene)-specific primers and pcr, the ebv latent membrane protein gene bnlf-1 was detected in 91 (61%) of the 150 tw samples from patients with tumors, including 25 (78%) of 32 patients with nasopharyngeal carcinoma and 66 (56%) of 118 other patients with ... | 1994 | 8126200 |
| epstein-barr virus (ebv) infects t lymphocytes in childhood ebv-associated hemophagocytic syndrome in taiwan. | we have reported the prevalence of a fulminant hemophagocytic syndrome (hs) in previously healthy young children in taiwan, most of which probably represent a lethal form of primary or active epstein-barr virus (ebv) infection. to further confirm their ebv association, in situ ebv hybridization (ish) was performed on tissue biopsies from 15 pediatric hs patients (median age, 3 years and 4 months) using digoxigenin-labeled rna probes eber1. double labeling immunostaining and ish was then performe ... | 1994 | 8203462 |
| immunoglobulin and t cell receptor beta chain gene rearrangements and epstein-barr viral dna in tissues of hodgkin's disease in taiwan. | nineteen patients with hodgkin's disease (hd), representing 4 different subtypes, were examined for immunophenotype and immunogenotype. quantitative immunophenotypic analysis of 13 cases revealed a predominance of leu1 and leu3 t cells in all subtypes, except in the case of hd lymphocytic-depression (hdld). the positive rate of leum1 and ki1 in reed-sternberg (rs) cells was 65% (11/17) and 73% (11/15), respectively. in dna hybridization analysis, 5 of the 19 cases of hd were found to have gene r ... | 1993 | 8395909 |
| study of epstein-barr virus early rna 1 (eber1) expression by in situ hybridization in thymic epithelial tumors of chinese patients in taiwan. | forty-one thymic epithelial tumors from chinese patients in taiwan, including 14 noninvasive thymomas, seven invasive thymomas, and 20 thymic carcinomas, were investigated for the presence of epstein-barr virus transcripts by in situ hybridization using digoxigenin-labeled riboprobes for eber1 expressions. none of the 14 noninvasive thymomas or seven invasive thymomas had detectable eber1. only one of 20 thymic carcinomas was positive for eber1. this positive tumor was a lymphoepithelioma-like c ... | 1993 | 8454269 |
| effect of hepatitis c antibody screening in blood donors on post-transfusion hepatitis in taiwan. | a national screening programme for antibody to hepatitis c virus (hcv) in blood donors in taiwan began in july 1992 using a second-generation immunoassay. to study the impact of this screening on post-transfusion hepatitis in taiwan, a prospective study on post-transfusion hepatitis, that was started in 1987, was continued. as of june 1994, 245 patients who received a blood transfusion after july 1992 had completed a follow-up period for more than 6 months post-transfusion. of them, seven (2.8%) ... | 1995 | 8527713 |
| expression of epstein-barr virus in carcinomas of major salivary glands: a strong association with lymphoepithelioma-like carcinoma. | to elucidate the role of epstein-barr virus (ebv) in salivary gland carcinomas, 56 cases of carcinomas of major salivary glands were investigated. these included 14 mucoepidermoid carcinomas, 13 adenoid cystic carcinomas, seven malignant mixed tumors, four adenocarcinomas, four salivary duct carcinomas, two acinic cell carcinomas, two undifferentiated carcinomas without lymphoid stroma, seven lymphoepithelioma-like carcinomas (lelcs), two squamous cell carcinomas, and one small cell carcinoma. e ... | 1996 | 8600040 |
| detection and sequence analysis of a new herpesvirus-like agent in aids and non-aids kaposi's sarcoma in taiwan. | a new herpesvirus-like dna sequence (kshv) has been recently identified in kaposi's sarcoma from acquired immunodeficiency syndrome (aids) and non-aids patients. in order to verify the role of this new viral agent in taiwan, a series of kaposi's sarcoma specimens obtained from aids and non-aids patients in three medical centers representing different geographic locations of taiwan were surveyed. a total of seven specimens from aids patients and 22 specimens from non-aids patients were tested for ... | 1996 | 8640089 |
| adult primary iga nephropathy and common viral infections. | serum samples obtained from 69 histopathologically proven iga nephropathy (igan) patients and 563 healthy controls were examined to evaluate the association between igan and common viral infections. antibody titres to cytomegalovirus (cmv), herpes simplex virus (hsv), vericella-zoster virus (vzv), influenza a (inf. a) and influenza b (inf. b) viruses were determined, using a complement fixation test. the viral antibody titres were considered to be positive with dilutions of 1:8 or greater except ... | 1996 | 8793713 |
| genomic analysis of epstein-barr virus in nasal and peripheral t-cell lymphoma: a comparison with nasopharyngeal carcinoma in an endemic area. | the epstein-barr virus (ebv) is prevalent in nasal and peripheral t-cell lymphoma (nptl) in taiwan, where nasopharyngeal carcinoma (npc) is endemic. in order to understand the pathogenesis of these two malignancies in this endemic area, genomic analysis of ebv in nptl with comparison to npc is important. we investigated the ebv subtype (types a and b), bamh-i "f" variant, and the xho-i site mutant of the latent membrane protein-1 (lmp-1) gene in 19 cases of ebv-associated nptl and in 30 cases of ... | 1996 | 8950688 |
| association between epstein-barr virus and burkitt's lymphoma in taiwan. | the association between epstein-barr virus (ebv) and burkitt's lymphoma (bl) in taiwan is not clear. in this study, the authors attempted to determine the frequency of the occurrence of ebv infection in patients with bl in taiwan. | 1997 | 9210717 |
| detection of epstein-barr virus in primary cutaneous amyloidosis. | to determine the association of epstein-barr virus (ebv) with primary cutaneous amyloidosis (pca), a retrospective study was conducted on skin tissue from 27 chinese patients with lichen amyloidosus and macular amyloidosis. in situ hybridization with oligonucleotide probes was used to detect the expression of ebv-encoded rnas (ebers). eleven of 27 cases (40.7%) were found to contain the ebv genome. no ebv genome was detected in the skin of the control groups, including three cases of secondary c ... | 1997 | 9217811 |
| undifferentiated carcinoma of the major salivary glands. | undifferentiated carcinoma of the salivary glands is a rare disease, the incidence of which is highest among the inuit of greenland and north america. it was demonstrated to be closely related to epstein- barr virus (ebv) infection. however, the relation of ebv to this tumor has not been studied to any great extent here in taiwan because of the small number of cases. | 1997 | 9241068 |
| detection of epstein-barr virus and htlv-i in t-cell lymphomas of skin in taiwan. | viral etiology has been associated with the pathogenesis of t-cell lymphomas of skin (tcls). therefore, we studied the presence of epstein-barr virus (ebv) and type i human t-cell lymphotropic virus (htlv-i) in tumor cells of tcls to determine the significance of these viruses with the disease. a retrospective study was conducted on the skin tissues from 28 chinese patients with tcls. we used in situ hybridization, immunohistochemistry, and polymerase chain reaction to determine the presence of ... | 1998 | 9650697 |
| expression of epstein-barr virus in patients with hodgkin's disease in taiwan. | the association of epstein-barr virus (ebv) with hodgkin's disease (hd) is intimately related to socioeconomic status. the proportion of hd patients with ebv is high in developing countries but low in developed countries. the aim of this study was to delineate the association of ebv with hd in taiwan. | 1998 | 9669821 |
| frequency of epstein-barr virus-associated gastric adenocarcinoma in taiwan. | eighty-two gastric adenocarcinomas (32 intestinal and 50 diffuse type) were investigated for the presence of epstein-barr virus (ebv) dna by amplifying the 78-bp fragment from the ebna1 gene with polymerase chain reaction. ebv was detected in 17 (20.7%) of the 82 gastric tumorous specimens. of these 17 ebv-positive cases, only one was ebv-positive in the adjacent non-tumorous tissue. ebv-positive gastric adenocarcinoma was present in 15.6 and 24.0% of the intestinal and diffuse type tumors, resp ... | 1998 | 9719452 |
| a study on epstein-barr virus in erythema multiforme. | | 1998 | 9763308 |
| viral etiology of intussusception in taiwanese childhood. | adenovirus infection and lymphoid hyperplasia have been associated with childhood intussusception. however, the extent of other viruses involved in this condition remains unclear. this prospective study investigates the relationship between some lymphotropic viruses and current childhood intussusception. | 1998 | 9802631 |
| clonal disease of natural killer large granular lymphocytes in taiwan. | lymphoproliferative diseases of large granular lymphocytes (ldgl) may arise from either cd3+ t cells or cd3- natural killer (nk) cells. ldgl with clonal proliferation of large granular lymphocytes (lgl) is defined as lgl leukaemia. the number of patients with nk-lgl leukaemia reported is limited and the pathogenesis of the disease is not yet clear. from 1991 to 1998 six patients with cytogenetically proved clonal disease of nk-lgl were identified in our institute. all were seropositive for epste ... | 1998 | 9886330 |
| lymphoepithelioma-like carcinoma of the stomach: a subset of gastric carcinoma with distinct clinicopathological features and high prevalence of epstein-barr virus infection. | to evaluate the clinicopathological features of lymphoepithelioma-like carcinoma of stomach in taiwan. | 1999 | 10370694 |
| suspected nasopharyngeal carcinoma in three workers with long-term exposure to sulphuric acid vapour. | sulphuric acid vapour has been suspected of being an industrial carcinogen. in this study, a cluster is presented of three patients with nasopharyngeal carcinoma (npc) who worked in the same building of a telecommunications conveyance station in southern taiwan with long term exposure to sulphuric acid vapour concentrations as high as 0.18 mg/m3. all three workers were diagnosed with npc within a 5 month period between september 1992, and march 1993. compared with 19 other healthy workers from t ... | 1999 | 10474541 |
| detection of epstein-barr virus in esophageal squamous cell carcinoma in taiwan. | recently, an association between viral infection and the development of esophageal carcinoma has been reported, particularly the human papilloma virus (hpv) and esptein-bar virus (ebv). however, geographic variation in carcinogenesis is realized. in this study, we investigate the viral carcinogenesis and the biologic effect of viral infection on esophageal squamous cell carcinoma (escc) in taiwan. | 1999 | 10520830 |
| autopsy findings on patients with aids in taiwan. | at national taiwan university hospital, from 1986 to 1996, autopsies were performed on 16 patients with acquired immunodeficiency syndrome. there were 15 men and 1 woman. fourteen of these male patients had contracted the disease as a result of sexual practice, among which 9 were homosexual, 1 was bisexual and 4 were heterosexual. one of the patients had become infected by sharing a syringe during intravenous drug use. the female was a sex worker. among these patients, only 2 had been tested for ... | 1997 | 10592820 |
| prevalence of the taiwan variant of the epstein-barr virus in nasopharyngeal carcinoma patients and normal individuals. | latent membrane protein 1 (lmp1) of epstein-barr virus (ebv) is a potentially oncogenic protein, able to inhibit differentiation and induce transformation of epithelial cells. the lmp1 gene sequence of ebv in nasopharyngeal carcinoma (npc) differs from that of ebv in b95-8 cells. a change of nucleotide at the xhoi site results in loss of the restriction site in the ebv lmp1 gene from npc, and this of ebv is designated as the taiwan variant. in this study, we further investigated the taiwan varia ... | 2000 | 10820907 |
| epstein-barr virus-associated gastric carcinomas: relation to h. pylori infection and genetic alterations. | the association of epstein-barr virus (ebv) and gastric carcinomas (gcs) has been shown to vary among different populations and certain histological subtypes. few studies have addressed the status of helicobacter pylori infection and genetic alterations in these ebv-positive or -negative gcs. | 2000 | 10833477 |
| epstein-barr virus detection in neck metastases by in-situ hybridization in fine-needle aspiration cytologic studies: an aid for differentiating the primary site. | nasopharyngeal carcinoma (npc) is strongly associated with epstein-barr virus (ebv). the metastasis to cervical lymph nodes represents a frequent initial manifestation of npc. the usefulness of ebv detection by polymerase chain reaction (pcr) in the diagnosis of occult npc with cervical metastasis has been reported. our previous study showed that eber1 in-situ hybridization was somewhat more sensitive and specific than pcr in detecting ebv in the evaluation of specimens from a population at high ... | 2000 | 10862015 |
| virus infection in patients with histiocytic necrotizing lymphadenitis in taiwan. detection of epstein-barr virus, type i human t-cell lymphotropic virus, and parvovirus b19. | the relationship of epstein-barr virus (ebv), type i human t-cell lymphotropic virus (htlv-i), and parvovirus b19 to histiocytic necrotizing lymphadenitis was studied prospectively in 10 taiwanese patients using materials obtained by fine-needle aspiration and lymph node biopsy. the presence of ebv was detected by in situ hybridization for ebv-encoded rna expression. immunocytochemistry was used to detect virus-encoded protein for ebv and parvovirus b19. dna in situ hybridization and polymerase ... | 2000 | 10874877 |
| malignant lymphoma in southern taiwan according to the revised european-american classification of lymphoid neoplasms. | the purpose of the current study was to determine the distribution and relative frequency of each subtype of malignant lymphoma in southern taiwan according to the revised european-american classification of lymphoid neoplasms (real). | 2000 | 11013375 |
| epstein-barr virus associated with immune thrombocytopenic purpura in childhood: a retrospective study. | although epstein-barr virus (ebv) is known to cause immune thrombocytopenic purpura (itp), the epidemiology of this pathogen in children with itp is not known. in the present study, the clinicoepidemiology and laboratory characteristics of ebv-associated itp in childhood were analysed retrospectively. | 2000 | 11036798 |
| use of bacterially expressed ebna-1 protein cloned from a nasopharyngeal carcinoma (npc) biopsy as a screening test for npc patients. | ebv serological tests have been used for many years as accessory diagnostic predictors of nasopharyngeal carcinoma (npc). to increase the sensitivity and specificity of the npc detection rate, a novel enzyme-linked immunosorbent assay (elisa) was established using a bacterially-expressed gst-ebna-1 protein, containing the ebna-1 sequence cloned from an npc patient. serum samples were collected from age- and gender-matched patients with npc, community control subjects and hospital control patient ... | 2001 | 11285569 |
| specific iga antibodies to recombinant early and nuclear antigens of epstein-barr virus in nasopharyngeal carcinoma. | nasopharyngeal carcinoma is a common cancer in taiwan. the epstein-barr virus (ebv) is closely associated with nasopharyngeal carcinoma. the sera of patients with nasopharyngeal carcinoma have iga antibodies to a variety of ebv latent and replicated antigens. recently, an enzyme-linked immunosorbent assay (elisa) kit, combining both the ebv early antigen (ea) and nuclear antigen (ebna-1) became commercially available. the purpose of this study was to assess its clinical application. serum iga an ... | 2001 | 11559349 |
| serologic markers of epstein-barr virus infection and nasopharyngeal carcinoma in taiwanese men. | it is probable but unproven that epstein-barr virus (ebv) has a role in nasopharyngeal carcinoma. we determined whether antibodies against ebv are present before the development of nasopharyngeal carcinoma. | 2001 | 11756578 |
| tumor necrosis factor-alpha and interleukin-10 promoter polymorphisms in epstein-barr virus-associated gastric carcinoma. | to investigate whether genetic differences in cytokine promoter polymorphisms effect various outcomes after exposure to epstein-barr virus (ebv) infection, 30 patients with ebv-positive gastric carcinoma (gc), 120 patients with ebv-negative gc, and 220 control subjects were enrolled. promoter polymorphisms of tumor necrosis factor (tnf)-alpha at positions -238 and -308 and of interleukin (il)-10 at position -1082 were determined. the frequency of the high-producer allele (-308a) in the tnf-alpha ... | 2002 | 11756988 |
| increased morbidity from nasopharyngeal carcinoma and chronic pharyngitis or sinusitis among workers at a newspaper printing company. | to determine the association between printing works and nasopharygeal carcinoma as well as other diseases. | 2002 | 11836464 |
| a two year follow-up study of common virus infections in hemodialysis patients in taiwan. | the study was designed to determine whether hemodialysis patients in taiwan had a different antibody response to common virus infections compared to the normal population. serum samples from 18 hemodialysis patients and 21 healthy volunteers were obtained every 3 months for 2 years. geometric mean titers (gmts) of immunoglobulin g (igg) antibodies to cytomegalovirus (cmv), herpes simplex virus (hsv), varicella-zoster virus (vzv), epstein-barr virus (ebv), as well as type a and type b influenza v ... | 2002 | 12296929 |
| association of hla class i and ii alleles and extended haplotypes with nasopharyngeal carcinoma in taiwan. | nasopharyngeal carcinoma (npc), which occurs at a disproportionately high rate among chinese individuals, is associated with epstein-barr virus (ebv). human leukocyte antigen (hla) polymorphisms appear to play a role in npc, because they are essential in the immune response to viruses. we used high-resolution hla genotyping in a case-control study in taiwan to systematically evaluate the association between various hla alleles and npc. | 2002 | 12464650 |
| screening nasopharyngeal carcinoma by detection of the latent membrane protein 1 (lmp-1) gene with nasopharyngeal swabs. | nasopharyngeal carcinoma (npc) is a common head and neck cancer in taiwan. the goals of the current study were to investigate whether a nasopharyngeal swab technique could provide enough dna for polymerase chain reaction (pcr) analysis of the epstein-barr virus (ebv)-derived latent membrane protein 1 (lmp-1) gene and to determine the feasibility and reliability of diagnosing npc by detection of lmp-1 in the nasopharynx. | 2003 | 12673717 |
| mutational events in lmp1 gene of epstein-barr virus in salivary gland lymphoepithelial carcinomas. | it is still unknown what kinds of roles epstein-barr virus (ebv) infection that are highly specific to salivary gland lymphoepithelial carcinomas (lecs) play in their tumorigenesis. to clarify the significance of ebv in lecs, we paid particular attention to the lmp1 gene, which is responsible for triggering several pathways for activating transcription factors. sixty-one cases of ebv positive lecs confirmed by pcr and in-situ hybridization were collected from various areas of the world and studi ... | 2003 | 12740914 |
| epstein-barr virus seroreactivity among unaffected individuals within high-risk nasopharyngeal carcinoma families in taiwan. | most adults have been infected with ebv. many studies have indicated that antibodies against specific ebv antigens, particularly iga antibodies, can be predictive or prognostic of ebv-associated malignancies, such as npc. we hypothesized that healthy individuals from families with a history of multiple members affected with npc (who therefore might be genetically susceptible to npc themselves) might have an ebv antibody profile that is distinct from that seen in healthy individuals from the comm ... | 2004 | 15185352 |
| amino acid changes in functional domains of latent membrane protein 1 of epstein-barr virus in nasopharyngeal carcinoma of southern china and taiwan: prevalence of an hla a2-restricted 'epitope-loss variant'. | full-length sequences of the epstein-barr virus (ebv) gene for latent membrane protein (lmp)-1 from 22 nasopharyngeal carcinoma (npc) biopsy specimens and 18 non-neoplastic counterparts (npi) were determined. relative to the b95-8 strain, the amino acid sequences of the toxic-signal and transformation domains were changed variably in npc and npi specimens; in contrast, no change was observed in the nf-kappab (nuclear factor kappab) activation domain. hla typing revealed that 47 % of npc and 31 % ... | 2004 | 15218188 |
| prevalence of lmp-1 gene in tonsils and non-neoplastic nasopharynxes by nest-polymerase chain reaction in taiwan. | the purpose of this study was to investigate the frequency of epstein-barr virus (ebv) latent membrane protein-1 (lmp-1) in tonsils and non-neoplastic nasopharynxes in taiwan. | 2004 | 15229905 |
| t-cell and nk/t-cell lymphomas in southern taiwan: a study of 72 cases in a single institute. | in an attempt to better understand the clinicopathologic features of t- and natural killer (nk)/t-cell lymphomas in taiwan and the distribution and relative frequency of each subtype according to the new who classification, the pathology file of a medical center in southern taiwan during 1989-2002 was retrospectively searched. the results of light microscopy, immunohistochemistry, in situ hybridization for epstein-barr virus (eber), and t-cell receptor (tcr)-gamma chain gene rearrangement were c ... | 2004 | 15291350 |
| epstein-barr virus infected lymphoepithelial carcinomas of the salivary gland in the russia-asia area: a clinicopathologic study of 160 cases. | in order to determine the prevalence of the epstein-barr virus (ebv) infection in salivary gland lymphoepithelial carcinomas (lec), we have collected 160 cases from asian countries and russia. all the cases examined by pcr for ebv dna bamhi fragment and in-situ hybridization for eber-1, ebv encoded small rna, showed positivity for ebv infection in lec cells, while no positive signals were found in any other salivary neoplasm examined. the incidence of lec was highest in guanzhou, followed by sha ... | 2003 | 15357246 |
| distribution and prognosis of who lymphoma subtypes in taiwan reveals a low incidence of germinal-center derived tumors. | to assess the distribution of lymphomas in taiwan according to the who (world health organization) classification, 175 recently diagnosed cases of malignant lymphomas were studied and the clinicopathologic data were analyzed. b-cell lymphomas accounted for 57.1% of cases, t-cell lymphomas 38.9%, and hodgkin's lymphoma 4%. extranodal lymphomas predominated (55.4%). the most common subtype of b-cell lymphoma was diffuse large b-cell lymphoma (33.1%). all tumor types believed to be derived from ger ... | 2004 | 15359636 |
| detecting epstein-barr virus dna from peripheral blood mononuclear cells in adult patients with systemic lupus erythematosus in taiwan. | epstein-barr virus (ebv) has been found by many serology studies to be associated with systemic lupus erythematosus (sle). however, the results of dna studies have been conflicting. therefore, instead of antibody to ebv, we studied the association between ebv dna and sle. in this case-control study in taiwan, we enrolled 87 sle patients and 174 age- and sex-matched controls. peripheral blood mononuclear cells of sle patients and matched controls were tested for ebv dna by polymerase chain reacti ... | 2005 | 15378356 |
| nasal nk/t cell lymphoma in taiwan: a clinicopathologic study of 22 cases, with analysis of histologic subtypes, epstein-barr virus lmp-1 gene association, and treatment modalities. | nasal nk/t cell lymphoma is a distinctive type of extranodal lymphoma with an unique immunophenotype and a strong association with epstein-barr virus (ebv). it is one of the common extranodal lymphomas in taiwan. we studied 22 cases of nasal nk/t cell lymphoma to characterize their clinicopathologic features and to explore the possible differences between histologic subtypes and their clinical behavior as well as the prevalence of 30-base pair (bp) deleted latent membrane protein-1 (lmp-1) gene ... | 2004 | 15494863 |
| correlation of viral factors with cervical cancer in taiwan. | the correlation of viral factors with cervical cancer was investigated. 27 cervical cancer biopsies and 29 normal cervical scrapings were determined by polymerase chain reaction method for 6 viruses, including human papillomavirus (hpv), cytomegalovirus (cmv), epstein-barr virus (ebv), herpes simplex virus (hsv)-1, hsv-2, and human herpes virus (hhv)-8. among 27 biopsies of cervical cancer, hpv was identified in 18. of these hpv-positive specimens, 9 cases of hpv type 16 were identified, 2 cases ... | 2004 | 15497009 |
| association of viral factors with non-familial breast cancer in taiwan by comparison with non-cancerous, fibroadenoma, and thyroid tumor tissues. | to study the etiologic factors of non-familial breast cancer, the polymerase chain reaction (pcr) and southern hybridization were used to detect six viruses including human papillomavirus (hpv), cytomegalovirus (cmv), epstein-barr virus (ebv), herpes simplex virus (hsv)-1, hsv-2, and human herpesvirus (hhv)-8 dna in 69 patients with breast cancer and 60 specimens from non-cancerous or other individuals with thyroid tumors or fibroadenoma (non-breast cancer controls). two specimens from patients ... | 2005 | 15602723 |
| high prevalence of immunoglobulin a antibody against epstein-barr virus capsid antigen in adult patients with lupus with disease flare: case control studies. | systemic lupus erythematosus (sle) is a severe autoimmune disease with rare remission and recurrent flare. epstein-barr virus (ebv) infection has been reported to be strongly associated with sle in the united states, but with an inconclusive role in asia. we investigated the role of ebv infection in patients with sle in taiwan, with one of the highest population densities in asia. | 2005 | 15630723 |
| distribution of epstein-barr viral load in serum of individuals from nasopharyngeal carcinoma high-risk families in taiwan. | the utility of ebv load as a tumor marker in nasopharyngeal carcinoma (npc) patients suggests that it might also serve as a screening test for individuals who are at high risk for developing npc. we previously demonstrated that unaffected individuals from high-risk families had elevated anti-ebv antibody levels compared to community controls. in this study, we measured ebv load using 2 different real-time pcr assays (targeting bamh1w and polymerase gene sequences, respectively) carried out in 2 ... | 2006 | 16106400 |
| primary lymphoepithelioma-like carcinoma of minor salivary gland: a case report with immunohistochemical and in situ hybridization studies. | lymphoepithelioma-like carcinomas (lec) of salivary glands represent rare epithelial malignancies, with most cases affecting the parotid gland. to our knowledge, there was only one lec arising from the minor salivary gland described in the english-language literature. | 2006 | 16240326 |
| functional assays of hla a2-restricted epitope variant of latent membrane protein 1 (lmp-1) of epstein-barr virus in nasopharyngeal carcinoma of southern china and taiwan. | human leukocyte antigen (hla) a2 was consistently associated with increased risk for nasopharyngeal carcinoma (npc) in chinese populations. previously we have reported that an epstein-barr virus (ebv) strain carrying an hla a2-restricted epitope variant of lmp-1 is prevalent in npc in southern china and taiwan (lin et al., j. gen. virol. 85: 2023-2034, 2004). the variant has mutation selectively involved one of the two anchor residues in position 2 (125 l-->f) and an additional mutation in posit ... | 2005 | 16307312 |
| sapinmusaponins f-j, bioactive tirucallane-type saponins from the galls of sapindus mukorossi. | five new tirucallane-type saponins, sapinmusaponins f-j (1-5), were isolated from the galls of sapindus mukorossi. the structures of these saponins were elucidated on the basis of spectroscopic analysis including 1d and 2d nmr techniques ((1)h-(1)h cosy, hmqc, hmbc, tocsy, and noesy). compounds 1-5 showed anti-platelet-aggregation effects, but no obvious cytotoxic activity for platelets as assayed by lactate dehydrogenase (ldh) leakage. compounds 1-5 also showed moderate activity in a 12-o-tetra ... | 2006 | 16724837 |
| clinicopathologic characteristics of rosai-dorfman disease in a medical center in northern taiwan. | rosai-dorfman disease (rdd) is a rare histiocytic proliferative disorder that usually presents as cervical lymphadenopathy. extranodal involvement occurs in up to 40% of patients. the disease is most prevalent in blacks and rare in asians. this study analyzed the characteristics of rdd in patients from taiwan. | 2006 | 16959617 |
| association of epstein-barr virus infection with systemic lupus erythematosus in taiwan. | an association between epstein-barr virus (ebv) infection and systemic lupus erythematosus (sle) has been suggested from previous serologic evidence. since most adults in taiwan are ebv-infected, seroepidemiologic studies based on standard assays for ebv are unlikely to dissociate sle patients and control groups. we reexamine this question by using novel methodologies in which iga anti-ebv-coded nuclear antigens-1 (ebna-1) and igg anti-ebv dnase antibodies were analysed by elisa, and ebv viral l ... | 2007 | 17432101 |
| clinical manifestations and quantitative analysis of virus load in taiwanese children with epstein-barr virus-associated infectious mononucleosis. | to delineate the clinical manifestations in different age groups and to define the viral load in patients with epstein-barr virus-associated infectious mononucleosis (ebv-associated im). | 2007 | 17639161 |
| childhood macrophage activation syndrome differs from infection-associated hemophagocytosis syndrome in etiology and outcome in taiwan. | hemophagocytic lymphohistiocytosis (hlh) is a syndrome composed of macrophage activation syndrome (mas), infection-associated hemophagocytosis syndrome (iahs), malignancy-associated hlh and genetic hlh. differentiation of mas from iahs and other hlh is important for early appropriate treatment. | 2007 | 17639169 |
| clinical aspects and molecular analysis of chinese patients with wiskott-aldrich syndrome in taiwan. | wiskott-aldrich syndrome (was) is an x-linked immunodeficiency, characterized by microthrombocytopenia, eczema and recurrent infections. more than 441 patient mutations have been described all over the world, mainly based on caucasian and japanese people. there have been few reported cases involving chinese was patients. | 2008 | 17703096 |
| computed tomography characteristics of primary pulmonary lymphoepithelioma-like carcinoma. | primary pulmonary lymphoepithelioma-like carcinoma is a very rare subtype of lung cancer. this report documents the ct features of 16 chinese patients diagnosed with primary pulmonary lymphoepithelioma-like carcinoma from january 1999 to december 2005. a pre-treatment ct was used to assess the tumour site, size, borders, pleural and vascular involvement, and the presence of lymph node involvement. the majority of the patients were female non-smokers with centrally located tumours. lymph node inv ... | 2007 | 17875600 |
| changing patterns in the frequency of hodgkin lymphoma subtypes and epstein-barr virus association in taiwan. | epstein-barr virus (ebv) infection is a risk factor for hodgkin lymphoma (hl). to test whether the frequency of hl subtypes and their association with ebv has shifted with rising socioeconomic status in taiwan, we compared the pathological features and ebv status, detected by in situ hybridization, of hl diagnosed between 1996 and 2007 (99 cases) and 1982 and 1995 (74 cases). the male-to-female ratio was 121:52 (2.3:1) and the mean age at presentation was 41.5 years. the overall ebv positivity r ... | 2008 | 18201268 |
| sporadic paediatric and adult burkitt lymphomas share similar phenotypic and genotypic features. | to characterize the clinicopathological features of sporadic burkitt lymphoma (bl). | 2008 | 18315595 |
| intestinal t-cell and natural killer-cell lymphomas in taiwan with special emphasis on 2 distinct cellular types: natural killer-like cytotoxic t cell and true natural killer cell. | primary intestinal lymphomas are rare, especially the t-cell and natural killer (nk)-cell types. enteropathy-type t-cell lymphoma (etl) is the most characteristic of the intestinal t-cell and nk-cell lymphomas (itnkls) defined in the world health organization classification. however, typical etl is rare in nonendemic areas for celiac disease, which include taiwan. with the exception of etls, itnkls comprise heterogeneous subtypes such as anaplastic large cell lymphoma, nasal-type nk/t-cell lymph ... | 2008 | 18482744 |
| clinical aspects, immunologic assessment, and genetic analysis in taiwanese children with hemophagocytic lymphohistiocytosis. | hemophagocytic lymphohistiocytosis (hlh) is a life-threatening syndrome characterized by immune disturbance associated with certain genetic defects. this study aimed to define the clinical spectrum, immunology, and candidate genes in hlh in taiwanese patients. | 2009 | 19057461 |
| cancer patterns in nasopharyngeal carcinoma multiplex families in taiwan. | genetic and environmental factors have been implicated in the etiology of nasopharyngeal carcinoma (npc), a tumor known to be closely associated with epstein-barr virus (ebv) infection. studies have reported familial aggregation of npc and have suggested the possible aggregation of npc and other cancers. we evaluated familial aggregation of cancer in 358 high-risk families with two or more npc cases enrolled in a npc genetics study in taiwan. participants were linked to the taiwan national cance ... | 2009 | 19065653 |
| genome-wide association study reveals multiple nasopharyngeal carcinoma-associated loci within the hla region at chromosome 6p21.3. | nasopharyngeal carcinoma (npc) is a multifactorial malignancy closely associated with genetic factors and epstein-barr virus infection. to identify the common genetic variants linked to npc susceptibility, we conducted a genome-wide association study (gwas) in 277 npc patients and 285 healthy controls within the taiwanese population, analyzing 480,365 single-nucleotide polymorphisms (snps). twelve statistically significant snps were identified and mapped to chromosome 6p21.3. associations were r ... | 2009 | 19664746 |
| prolonged acquired neutropenia in children. | acquired neutropenia is not uncommon in childhood. this study investigated the risk factors associated with developing prolonged acquired neutropenia. | 2009 | 19711442 |
| preirradiation sinus mucosal disease in patients with nasopharyngeal carcinoma. | the objective of this study was to evaluate the incidence and the possible risk factors for preirradiation abnormalities of the sinus mucosa in patients with nasopharyngeal carcinoma (npc) by magnetic resonance imaging. | 2009 | 19720246 |
| detection of ebv infection and gene expression in oral cancer from patients in taiwan by microarray analysis. | epstein-barr virus is known to cause nasopharyngeal carcinoma. although oral cavity is located close to the nasal pharynx, the pathogenetic role of epstein-barr virus (ebv) in oral cancers is unclear. this molecular epidemiology study uses ebv genomic microarray (ebv-chip) to simultaneously detect the prevalent rate and viral gene expression patterns in 57 oral squamous cell carcinoma biopsies (oscc) collected from patients in taiwan. the majority of the specimens (82.5%) were ebv-positive that ... | 2009 | 20011069 |
| familial tendency and risk of nasopharyngeal carcinoma in taiwan: effects of covariates on risk. | in the present study, the authors compared the long-term risk of nasopharyngeal carcinoma (npc) of male participants in an npc multiplex family cohort with that of controls in a community cohort in taiwan after adjustment for anti-epstein-barr virus (ebv) seromarkers and cigarette smoking. a total of 43 incident npc cases were identified from the 1,019 males in the npc multiplex family cohort and the 9,622 males in the community cohort, for a total of 8,061 person-years and 185,587 person-years, ... | 2010 | 21148719 |
| human papilloma virus detection in neoplastic and non-neoplastic nasopharyngeal tissues in taiwan. | background human papilloma virus (hpv) has been implicated in the carcinogenesis and prognosis of certain head and neck cancers. whether it also has a role in the pathogenesis of nasopharyngeal carcinoma (npc) in taiwan is unclear. methods detection and genotyping of hpvs were performed in 43 primary npcs (one who-i and 42 who-ii/iii) and 40 nasopharyngeal controls using pcr-based hpv genotyping arrays. localisation of high-risk hpv and epstein-barr virus genomes was performed in another 46 prim ... | 2011 | 21512108 |
| nasopharyngeal carcinoma with pericardial metastasis. | nasopharyngeal carcinoma (npc) is prevalent in taiwan and is characterized by a high frequency of nodal metastasis. the most common organs with distal metastases are the bones, lungs, and liver, with extremely rare cases to the pericardium. herein, we report a rare case with npc who presented with dyspnea and orthopnea. serial studies, including pericardial biopsy, revealed npc with pericardial metastasis and pericardial effusion. the tumor cells of both the original and metastatic tumors were p ... | 2011 | 21757147 |
| clinical analysis of fever of unknown origin in children: a 10-year experience in a northern taiwan medical center. | fever of unknown origin (fuo) was first described in 1961 as fever >38.3°c for at least 3 weeks with no apparent source after 1 week of investigations in the hospital. infectious disease comprises the majority of cases (40-60%). there is no related research on fuo in children in taiwan. the aim of this study is to determine the etiologies of fuo in children in taiwan and to evaluate the relationship between the diagnosis and patient's demography and laboratory data. | 2017 | 25735796 |
| metformin and esophageal cancer risk in taiwanese patients with type 2 diabetes mellitus. | this study evaluated whether metformin might reduce esophageal cancer risk. patients with type 2 diabetes mellitus diagnosed during 1999-2005 were recruited from the reimbursement database of taiwan's national health insurance. those newly treated with metformin (n = 288013, "ever users of metformin") or other antidiabetic drugs (n = 16216, "never users of metformin") were followed until december 31, 2011. sensitivity analyses were conducted in a matched-pair sample of 16216 never users and 1621 ... | 2016 | 27861146 |
| birth order and risk of nasopharyngeal carcinoma in multiplex families from taiwan. | a small proportion of individuals infected with epstein-barr virus (ebv) develop nasopharyngeal carcinoma (npc). timing of initial exposure could alter immunological responses to primary ebv infection and explain variation in cancer risk later in life. we measured early life family structure as a proxy for the timing of primary ebv infection to examine whether earlier age at infection alters npc risk. we utilized data from 480 npc cases and 1,291 unaffected siblings from taiwanese npc multiplex ... | 2016 | 27537611 |