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sibship size, helicobacter pylori infection and chronic atrophic gastritis: a population-based study among 9444 older adults from germany.early-life social environment has been suggested to play an important role during the development of helicobacter pylori-related gastric diseases. we aimed to assess the association of sibship size with h. pylori infection and chronic atrophic gastritis (cag) in a population-based study from germany.201019596750
grb2-associated binder 1 (gab1) genetic polymorphism, helicobacter pylori infection, and chronic atrophic gastritis among older adults from germany.grb2-associated binder 1 (gab1) plays an important role in the regulation of cell growth and transformation. a single nucleotide polymorphism (snp) (rs3805246) in the gab1 gene has been suggested to be related to the risk of helicobacter pylori infection and chronic atrophic gastritis (cag) in a study from japan. we aimed to assess the associations in a population-based study from germany. in the baseline examination of esther, a population-based study conducted in saarland, serum pepsinogen i a ...201020602450
is helicobacter pylori infection a necessary condition for noncardia gastric cancer?although the association between helicobacter pylori infection and gastric cancer is well established, this association might have been underestimated in epidemiologic studies because of possible clearance of the infection in the course of disease development. the authors addressed this hypothesis in a case-control study from saarland, germany (68 cases first diagnosed between 1996 and 1998 and 360 controls), with serologic assessment of h. pylori infection in which various exclusion criteria we ...200414742285
alcohol consumption and chronic atrophic gastritis: population-based study among 9,444 older adults from germany.moderate alcohol consumption has been suggested to facilitate elimination of helicobacter pylori infection which is a key risk factor for chronic atrophic gastritis (cag) and gastric cancer. the aim of our study was to assess the association of alcohol consumption with cag among older adults from germany. in the baseline examination of esther, a population-based study conducted in saarland, serological measurements of pepsinogen i and ii (for cag definition) and h. pylori antibodies were taken i ...200919637315
helicobacter pylori infection and gastric cancer risk: evaluation of 15 h. pylori proteins determined by novel multiplex serology.infection with helicobacter pylori is a major cause of gastric cancer (gc). the association likely has been underestimated in the past due to disease-related clearance of the infection. on the other hand, only a minority of the infected individuals develop gc, and better risk stratification is therefore highly desirable. we aimed to assess the association of gc with antibodies to 15 individual h. pylori proteins, determined by novel multiplex serology, to identify potentially relevant risk marke ...200919602590
helicobacter pylori infection and chronic atrophic gastritis: associations according to severity of disease.helicobacter pylori infection is an established risk factor for chronic atrophic gastritis. however, estimates of the strength of this association have varied widely, possibly due to clearance of the infection in severe stages of chronic atrophic gastritis, which may lead to underestimation of the association. we assessed the association of h. pylori infection with chronic atrophic gastritis according to severity of disease.200919404195
epidemiologic findings on serologically defined chronic atrophic gastritis strongly depend on the choice of the cutoff-value.chronic atrophic gastritis (cag), a precursor of intestinal gastric cancer, is mostly ascertained noninvasively by serum pepsinogens in epidemiologic studies. however, serological definitions vary widely. we aimed to investigate the impact of this variation on estimated prevalence of cag and its association with its main risk factors, age and helicobacter pylori infection. serum pepsinogen i and ii and antibodies against h. pylori were measured by elisa among 9,444 women and men aged 50-74 years ...200717691112
incidence of gastric b-cell lymphomas: a population-based study in germany.while the clinical and experimental knowledge concerning gastric lymphomas is increasing, there is a scarcity of epidemiological data.200212176793
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