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screening for subclinical complications in young type 1 diabetic patients: experience acquired in brussels.clinical studies conducted since the 1970s by the pediatric diabetology group of the free university of brussels have demonstrated that screening for subclinical retinopathy, neuropathy and nephropathy should be started at puberty and at least 3 years after the diabetes diagnosis. the goal is to detect early abnormalities responsible for subclinical disorders that can be reversed by improved metabolic control, thus preventing the occurrence of irreversible potentially incapacitating lesions. a 1 ...200416437030
primary antimicrobial resistance of helicobacter pylori in belgium.the increasing antimicrobial resistance of helicobacter pylori jeopardizes the efficiency of the classical eradication triple therapy. in this article we assessed the primary resistance rates of helicobacter pylori to the commonly used antibiotics for eradication in the area of brussels and determined prospectively, through a questionnaire, the possible risk factors for resistance. gastric biopsies were taken for histology and culture in all adult patients in whom helicobacter pylori was searche ...201624156217
[screening for subclinical complications in children and adolescents with type 1 diabetes: experience acquired in brussels].clinical studies conducted since the 1970s by the pediatric diabetology group of the free university of brussels have demonstrated that screening for subclinical retinopathy, neuropathy, and nephropathy should be started at puberty and at least 3 years after the diabetes diagnosis with the goal of detecting early abnormalities responsible for subclinical disorders that can be reversed by improved metabolic control, thus preventing the occurrence of irreversible potentially incapacitating lesions ...201021812221
helicobacter pylori positivity in belgium.epidemiological data about the prevalence of helicobacter pylori positivity are presented in a large population of symptom-free paediatric and adult patients in belgium (n: 1180, age range: 1 to 40 years). the investigated patients belonged to different ethnic backgrounds and are representative for the general population of brussels. the overall prevalence of helicobacter pylori positivity was 18.0%. we observed a significant increase in the number of positive patients with advancing age, rangin ...19957604666
marching cohort of helicobacter pylori infection over two decades (1988-2007): combined effects of secular trend and population migration.the prevalence of helicobacter pylori infection is decreasing in developed countries. in this study we included 22,612 patients in whom a first culture of gastric biopsy (routinely performed in our medical centres) yielded an interpretable result over a 20-year period (1988-2007) in brussels. the effects of patients' age, gender and ethnic background were analysed. the overall proportion of h. pylori-infected patients was 37·7%, with a progressive decline over time (p<10(-5)). a gender effect wa ...201120525410
multicenter survey of routine determinations of resistance of helicobacter pylori to antimicrobials over the last 20 years (1990 to 2009) in belgium.we analyzed the rates of antimicrobial resistance of helicobacter pylori strains isolated from patients from 1990 to 2009 and identified risk factors associated with resistance. gastric biopsy specimens were collected from several digestive disease centers in brussels, belgium. we routinely performed antimicrobial susceptibility testing for clarithromycin (clr), metronidazole, amoxicillin, tetracycline, and ciprofloxacin. evaluable susceptibility testing was obtained for 9,430 strains isolated f ...201121450969
follow-up of helicobacter pylori infection in children over two decades (1988-2007): persistence, relapse and acquisition rates.helicobacter pylori culture on gastric biopsy was performed on 4964 subjects aged <18 years from 1988 to 2007 at a central laboratory in brussels. the total number of biopsies increased markedly from 941 in 1988-1993 to 1608 in 2004-2007. biopsies were repeated at least once for 922 subjects (603 initially negative and 319 initially positive for h. pylori). persistence rate of h. pylori at 1 year after initial positive biopsy was greater in the 1998-2007 cohort than in the 1988-1997 cohort (72.7 ...201423809783
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