progress in the development of helicobacter pylori strain typing methods.helicobacter pylori is very different from other gram negative bacteria that inhabit the human gastroduodenal tract. its success in adapting to colonise and persist in the stomach is reflected in key features such as unique chemical structure and architecture of lipopolysaccharide, sheathed flagella, genomic diversity, and potent urease activity. strain diversity within the species is well established and so the challenge is to exploit variations in these features for developing relevant epidemi ...19989644129
helicobacter pylori infection and mortality from ischaemic heart disease: negative result from a large, prospective determine whether there is an independent association between helicobacter pylori infection of the stomach and ischaemic heart disease.19979393222
hunterian peptic ulcers and helicobacter pylori.gastric spiral organisms were first described in man in 1939 and identified as helicobacter pylori causing peptic ulcers in the early 1980s. surgical specimens of gastric resections from 1939 showed h. pylori to be present. full-thickness sections of gastric mucosa from gastric specimens from the eighteenth-century hunterian collection at the royal college of surgeons of england were examined by histology for the presence of h. pylori. four gastric ulcers and a section from an oesophageal varix ...19979326130
helicobacter pylori reinfection after apparent eradication--the ipswich experience.the reported rate of helicobacter pylori reinfection following eradication therapy is highly variable. in ipswich, the 14c-urea breath test (ubt) has been used since 1986 as a tool to study h. pylori eradication and reinfection. updated results from 1182 patients in whom the organism had apparently been successfully eradicated, following a number of different eradication regimens between october 1986 and 31 march 1995, are presented. during this period, 57 "reinfections' were observed, of which ...19968722391
variability in serum pepsinogen levels in an asymptomatic investigate the variability in serum pepsinogen levels in an asymptomatic population.19958590160
genetic diversity of helicobacter pylori indexed with respect to clinical symptomatology, using a 16s rrna and a species-specific dna probe.dna probes are described which identify group and fingerprint strains of the human gastric pathogen helicobacter pylori, on the basis of well-defined band homologies. a 544 bp internal fragment of the 16s ribosomal rna gene was generated by polymerase chain reaction (pcr) with primers derived from the escherichia coli rrna gene sequence. in genomic southern blots this probe detected restriction site variation around these loci, generating simple but strain-specific molecular fingerprints. a smal ...19938294306
gastric cancer and helicobacter pylori identify differences in the prevalence of helicobacter pylori infection in different groups of patients with gastric cancer.19938254106
high prevalence of helicobacter pylori metronidazole resistance in migrants to east london: relation with previous nitroimidazole exposure and gastroduodenal disease.a high prevalence of metronidazole resistance in helicobacter pylori is reported in developing countries. this study examined whether migrants referred for diagnostic gastroscopy at a united kingdom centre (n = 54), had a higher prevalence of metronidazole resistance than subjects born in the united kingdom attending endoscopy (n = 46). records of nitroimidazole treatment prescribed in the united kingdom was obtained in 83 patients to find out if there was an association between h pylori metroni ...19947828973
primary gastric lymphoma in clinical practice 1973-1992.this study assessed the presentation, treatment, and prognosis of primary gastric lymphoma in general hospital practice and its relation to infection with helicobacter pylori. the number of patients that would on the current recommendations have been suitable for h pylori eradication therapy was also examined. all lymphomas were graded according to a standard classification of gut lymphoma into high and low grade disease. forty five patients (mean age 65 years) were identified. the overall five ...19957797116
the prevalence of helicobacter pylori infection in patients with intestinal metaplasia and in controls: a serological and histological study in four united kingdom centres. the uk sub-group, the ecp-euronut intestinal metaplasia study group. 19947735051
recurrent abdominal pain and helicobacter pylori in a community-based sample of london children.helicobacter pylori is accepted as an important factor in the pathogenesis of peptic ulcer disease. infection is probably most commonly acquired in early life but there is still limited information on the prevalence or symptomatology of h. pylori infection in childhood. the aim of the present study was to establish the prevalence of h. pylori infection in a large sample of urban school children and to determine its relationship, if any, to a history of recurrent abdominal pain. using a commercia ...19968863879
seroepidemiology of helicobacter pylori infection in vegans and enzyme-linked immunosorbent assay has been used to diagnose serologically the prevalence of helicobacter pylori infection in asian life-long vegans. there was no difference in the seropositivity between these individuals and a group of age- and sex-matched asian meat-eaters, indicating the meat consumption is not a risk factor for h. pylori infection. however, both asian groups had a higher prevalence of infection than age- and sex-matched caucasian meat-eaters. additionally, the asian indivi ...19921601079
childhood living conditions and helicobacter pylori seropositivity in adult life.infection with helicobacter pylori increases an individual's risk of peptic ulceration and gastric cancer. in the developed world, prevalence of infection rises with age and varies with social class. we used a cross-sectional study design to test the hypothesis that h pylori infection would be more closely associated with childhood living conditions than with current socioeconomic status. prevalence of igg antibodies against h pylori was determined with an enzyme-linked immunosorbent assay in 21 ...19921348299
helicobacter pylori infection and upper gastrointestinal pathology in a british immigrant indian community. 19979222746
why is mortality higher in poorer areas and in more northern areas of england and wales?to identify and quantify the factors responsible for the differences in mortality between affluent and deprived areas, the north and the south, and urban and rural areas in england and wales.19989764254
results of helicobacter pylori screening and eradication in a multi-ethnic community in central determine the prevalence of helicobacter pylori and risks for infection in a multi-ethnic inner city population, and to assess the effectiveness with which the infection can be eradicated in a relatively asymptomatic population of this type.19989872619
is helicobacter pylori transmitted from cats to humans?subsequent to the isolation of helicobacter pylori from domestic cats, it has been suggested that the organism might be transmitted from cats to humans. this hypothesis has already gained considerable media attention.19969398882
association between infection with helicobacter pylori and risk of gastric cancer: evidence from a prospective investigate the association between gastric cancer and prior infection with helicobacter pylori.19912059685
how might general practitioner knowledge of patient helicobacter pylori status change the management of dyspepsia in primary care?recent guidelines have suggested that testing young dyspeptic patients for helicobacter pylori infection will produce more appropriate referrals for endoscopic investigation. our aim was to describe how awareness of patient h. pylori status changes the practice of general practitioners (gps) who do not currently use h. pylori testing and/or eradication in their management of dyspepsia. we studied a 5 per cent systematic sample (n = 177), stratified by health authority, of gps in the north west r ...19989675728
strong correlation between helicobacter pylori seropositivity and chlamydia pneumoniae igg concentrations. 199810396525
the clo test in the uk: inappropriate reading and missed endoscopy units, the clo test is frequently used to detect helicobacter pylori (h. pylori). informal survey suggested that practice deviated from that recommended, with little account taken of possible confounders such as acid-suppressing medication.199910563535
reasons for non-compliance with screening for infection with helicobacter pylori, in a multi-ethnic community in leicester, this study, we aimed to identify reasons for non-compliance with a screening programme for helicobacter pylori (h pylori), in a multi-ethnic community and to assess the effectiveness of asian language materials towards increasing compliance. a serological screening test for infection with h pylori was offered to 200 asians and 200 non-asians (mainly europeans), aged 21-55 y, registered at a single general practice. reasons for non-attendance for screening were identified by reply slip or inte ...19989629021
is infection control an academic study?this editorial aims to answer the question of whether infection control is an academic specialty. by considering the consequences of a lack of infection control in terms of patient morbidity and mortality and hence cost, it is easy to establish the importance of the area. infection control embraces not only developing policies for preventing the physical spread of a micro-organism but also prophylactic therapy such as vaccination and therapeutic measures such as antibiotics. infection control no ...19999949958
prospective relations between helicobacter pylori infection, coronary heart disease, and stroke in middle aged determine whether helicobacter pylori, a chronic bacterial infection often acquired in childhood, is associated with increased risk of coronary heart disease and stroke later in life.19968697158
migration and helicobacter pylori seroprevalence: bangladeshi migrants in the u.k.helicobacter pylori, an infectious agent of worldwide public health importance, has higher seroprevalence in developing countries than in developed countries. we investigated whether bangladeshi women, born in bangladesh, have a greater h. pylori seroprevalence than bangladeshi women born in the u.k. and, in addition, whether there is an association between h. pylori seropositivity and age of migration to the u.k. amongst bangladeshi women. women attending antenatal clinics at the royal london h ...19958666843
c reactive protein and its relation to cardiovascular risk factors: a population based cross sectional test the hypothesis that minor chronic insults such as smoking, chronic bronchitis, and two persistent bacterial infections may be associated with increases in c reactive protein concentration within the normal range and that variations in the c reactive protein concentration in turn may be associated with levels of cardiovascular risk factors and chronic coronary heart disease.19968616412
association of helicobacter pylori and chlamydia pneumoniae infections with coronary heart disease and cardiovascular risk investigate the relation between seropositivity to chronic infections with helicobacter pylori and chlamydia pneumoniae and both coronary heart disease and cardiovascular risk factors.19957549683
changing pattern of gastric cancer in oxfordshire.this study compares the incidence rates of histologically confirmed gastric carcinoma in oxfordshire in two five year periods (1960-64, 1984-88). data were available for 215 patients in the first period, and 200 in the second. the overall incidence fell from 18/100,000 to 15/100,000 but when analysed for site, the incidence of antral tumours fell from 10 to 4.5/100,000. in contrast, there was an increase from 2.8 to 5.2/100,000 of tumours of the cardia. these changes were more pronounced in men. ...19921446851
a study of general practitioners' reasons for changing their prescribing explore general practitioners' reasons for recent changes in their prescribing behaviour.19968616310
prevalence of helicobacter pylori at oral and gastrointestinal sites in children: evidence for possible oral-to-oral transmission.acquisition of helicobacter pylori occurs mainly in childhood. however, the mode of transmission remains unclear. to help elucidate this, 100 children attending for upper gastrointestinal endoscopy were investigated for the presence of h. pylori at various sites. h. pylori was detected in antral gastric biopsies by the rapid urease test (13 patients), culture (13 patients), histology (15 patients) and pcr (20 patients). gastric juice was positive for h. pylori in 3 patients by culture and 11 pat ...200211926736
relation between infection with helicobacter pylori and living conditions in childhood: evidence for person to person transmission in early relate the prevalence of infection with helicobacter pylori in adults to their living conditions in childhood to identify risk factors for infection.19948142828
is untargeted outreach visiting in primary care effective? a pragmatic randomized controlled trial.there is increasing evidence that clinical guidelines can lead to improvements in clinical care. however, they are not self-implementing. outreach visits may improve prescribing behaviour.200111450926
hospital admissions for peptic ulcer and indigestion in london and new york in the 19th and early 20th centuries.the occurrence of peptic ulcer increased rapidly in all western countries from the 19th to the 20th century, attributed to a possible epidemic of helicobacter pylori, a new pathogenic strain, or a change in host susceptibility. the early trends in hospital admissions for peptic ulcer and dyspepsia in london and new york during the 19th century are reviewed to test these hypotheses.200211889081
the burden of helicobacter pylori infection in england and wales.the prevalence of active infection with helicobacter pylori in the general population of england and wales was estimated using high reactivity for specific igg in serum elisa as a marker. a total of 10,118 anonymized residues of serum samples collected in 1986 and 1996 from persons aged 1-84 years were used. estimated prevalence of active infection varied by region and was highest in london. prevalence was related to decade of birth and increased from 4-3% in those born during the 1980s to 30% i ...200212113485
relation of adult lifestyle and socioeconomic factors to the prevalence of helicobacter pylori infection.the influence of adult socioeconomic status, co-habitation, gender, smoking, coffee and alcohol intake on risk of helicobacter pylori infection is uncertain.200212055165
relationship between the birth cohort pattern of helicobacter pylori infection and the epidemiology of duodenal ulcer.helicobacter-pylori-related duodenal ulcer (du) is an important cause of dyspepsia.200212145391
a placebo-controlled randomized trial of eradication of helicobacter pylori in the general population: study design and response rates of the bristol helicobacter project.the bristol helicobacter project is an ongoing, pragmatic, double-blind placebo-controlled trial of the effect of helicobacter pylori eradication on symptoms of dyspepsia, health utilization and costs, and quality of life in the adult population. commencing in 1996, 27,536 individuals ages 20-59 years who were registered with seven primary care centers in bristol and the surrounding areas in southwest england were invited to undergo a 13c urea breath test. there was no selection on the basis of ...200212057883
surveillance and clinical relevance of vaca genotypes of helicobacter pylori infecting dyspeptic patients in mid-essex.the helicobacter pylori vacuolating cytotoxin is a putative pathogenicity factor encoded by vaca, a mosaic gene with a global distribution. the vaca type prevalence and diversity of h. pylori isolated from antral gastric biopsies of 360 dyspeptic patients in mid-essex, and of 79 patients from other locations, were investigated in order to test for links with disease severity. mid (m)-region genotyping and subtyping by vaca haeiii rflp (restriction fragment length polymorphism) analysis showed th ...200212166294
general population screening for infection with helicobacter pylori: a realistic option?to consider the effectiveness of a community programme of helicobacter pylori (h pylori) screening and eradication run in collaboration with general practitioners. specifically, to assess numbers successfully eradicating h pylori and consequently reducing the prevalence of infection, and to identify and consider areas of poor compliance.19989795878
increased risk of infection with helicobacter pylori in spouses of infected subjects: observations in a general population sample from the investigate risk factors for infection with helicobacter pylori in a general population sample who accepted an invitation to be screened. in particular, to determine whether being the spouse of an infected subject is an independent risk factor for infection after adjustment for other risks.200010791206
epidemiology of duodenal ulcer perforation: a study on hospital admissions in norfolk, united kingdom.studies on the incidence of perforated duodenal ulcer are limited and in the united kingdom, data are largely based on findings observed over two decades ago. to provide updated epidemiological data on duodenal ulcer perforation, the incidence of the disease in norfolk, united kingdom was determined.200212118948
population-based and opportunistic screening and eradication of helicobacter pylori. an analysis using trial baseline data. leeds h. pylori study examine whether screening and eradication of helicobacter pylori by population-based invitation or opportunistic screening by general practitioners reduces costs to the national health service (nhs) of treating dyspepsia.199910645106
localised extranodal non-hodgkin's lymphoma of the gastrointestinal tract: sheffield lymphoma group experience (1989-1998).extranodal non-hodgkin's lymphoma (nhl) of the gastrointestinal tract accounts for about one third of all extranodal nhl. we retrospectively reviewed the clinical and histopathologic records of 71 patients with stage ie and iie primary gastrointestinal nhl referred to the sheffield lymphoma group (slg) from 1989 to 1998. cross-referencing with the hospital histopathology department database revealed that only two-thirds of all cases were seen by the group. the most common primary site was the st ...200111251169
inverse relationship between alcohol consumption and active helicobacter pylori infection: the bristol helicobacter project.the aim of this study was to examine whether smoking or consumption of alcohol or coffee is associated with active helicobacter pylori (h. pylori) infection.200212425543
the cost-effectiveness of screening for helicobacter pylori to reduce mortality and morbidity from gastric cancer and peptic ulcer disease: a discrete-event simulation model. 200312709294
development and application of a novel screening pcr assay for direct detection of 'helicobacter heilmannii'-like organisms in human gastric biopsies in southeast england.a novel pcr assay (hhlo-16) to screen for presence of 'helicobacter heilmannii'-like organisms (hhlo) direct from gastric biopsies is described. as 'h. heilmannii' is generally uncultivable, diagnosis of infection is reliant on histology; thus prevalence may be underestimated. analysis of an hhlo histology-positive human gastric biopsy and 15 gastric biopsies from domestic cats demonstrated that the hhlo-16 assay was more sensitive than an alternative available species-specific pcr assay. furthe ...200312742311
recent trends in admissions and mortality due to peptic ulcer in england: increasing frequency of haemorrhage among older subjects.although overall admission rates for peptic ulcer in england declined from the 1950s up until the mid 1980s, perforations among older women increased, possibly due to increasing use of non-steroidal anti-inflammatory drugs (nsaid). since then, proton pump inhibitors, antibiotic treatment for helicobacter pylori, low dose aspirin, and selective serotonin reuptake inhibitors (ssri) have been introduced aims: to determine time trends for hospital admissions for peptic ulcer from 1989 to 1999 (engla ...200211889062
helicobacter pylori: antibiotic resistance and eradication rates in suffolk, uk, 1991-2001.helicobacter pylori infection causes a number of gastrointestinal diseases and its current treatment is based on multidrug regimes including acid suppression and antimicrobials. the success of these regimes is determined by a number of factors including antibiotic resistance, which varies widely but is an increasing problem. local data are important in establishing the most cost-effective eradication regime. data have been collected prospectively on antibiotic resistance at ipswich hospital (suf ...200415150334
do all patients in primary care who may benefit from eradication of helicobacter pylori have access to effective care?the purpose of this study was to identify those patients who would benefit from eradication therapy for helicobacter pylori and to understand the scale of service changes needed to implement eradication therapy. all general practices in bradford health authority were invited to take part in the study. patients who had received more than one repeat prescription for proton pump inhibitors or h(2) receptor antagonists in the previous twelve months were identified using the repeat prescription syste ...200111464301
detection of helicobacter pylori by pcr but not culture in water and biofilm samples from drinking water distribution systems in investigate treated water distribution systems in england as a source of helicobacter pylori.200415357718
helicobacter pylori antibiotic-resistance patterns and risk factors in adult dyspeptic patients from ethnically diverse populations in central and south london during 2000.surveillance of helicobacter pylori antibiotic susceptibility from patients in london, the largest metropolitan area in the uk, is limited, despite resistance being a key factor in treatment failure. a two-centre survey was performed over 12 months (1999-2000) to determine antibiotic-resistance rates of isolates from dyspeptic patients attending endoscopy clinics serving two ethnically diverse central and south london communities. the in vitro antibiotic susceptibilities were determined from dis ...200515888466
amplified fragment length polymorphism genotyping of metronidazole-resistant helicobacter pylori infecting dyspeptics in england.intra-specific diversity of helicobacter pylori infecting stomachs of different individuals was investigated by numerical analysis of amplified fragment length polymorphisms (aflp), to determine the existence of clones within the strain population and the effect that antibiotic treatment, particularly with metronidazole (mtz), had on the balance of types/subtypes present before and after treatment.200111422251
reducing dyspepsia costs in the community. 200212235096
phls primary care consultation--infectious disease and primary care research and service development 1999 for the first time the phls undertook a questionnaire survey of general practitioners' views of the burden of infectious disease and the priorities for research and development of infectious disease services within the phls. three hundred and seventy-one (38%) of 979 questionnaires mailed to chairs of primary care groups in england, and general practitioners in research networks, were returned. service areas: computer transfer of laboratory results was considered of greatest priority. gu ...200111467013
non-invasive diagnosis of helicobacter pylori infection in adult dyspeptic patients by stool antigen detection: does the rapid immunochromatography test provide a reliable alternative to conventional elisa kits?stool antigen-testing allows non-invasive detection of helicobacter pylori that is indicative of active infection. three commercial kits are currently marketed in the uk for stool antigen-testing. the aim of this study was to conduct a comparative evaluation of the performances of each of these tests, compared with culture and histological examination of gastric biopsies, for pre-treatment diagnosis of infection in an adult dyspeptic population in south-east england. examination of 112 stool sam ...200415184532
a simulation to evaluate screening for helicobacter pylori infection in the prevention of peptic ulcers and gastric cancers.a discrete event simulation model has evaluated a screening programme for helicobacter pylori infection (h. pylori) in which individuals under the age of 50 years would be screened once. eradication of h. pylori would reduce the peptic ulcer risk immediately and the gastric cancer risk after a fixed delay. the data were derived from published databases and peer reviewed papers. the simulation model, using variance reduction techniques, predicted that a screening programme would reduce morbidity ...200212437272
association between helicobacter pylori infection and adult height.a cross-sectional survey was performed to evaluate the association between h. pylori and adult height.200516080594
edkins and a century of acid 1905, john edkins (1863-1940) undertook the studies of gastrin that have subsequently formed the basis for a century of investigation into the physiological basis of acid secretion and led to the elucidation of a variety of acid-suppressive pharmacological agents that have revolutionized the management of acid peptic disease. although his name is known to few, his contributions to the physiology of gastric secretion and his study of spiral organisms in the stomach were prescient and to this d ...200516172550
inequity of upper gastrointestinal cancer distribution and survival with socioeconomic deprivation: a population-based is postulated that patients with upper gastrointestinal cancers from affluent classes have better survival outcomes than those from deprived backgrounds. we aimed to analyze the incidence, mortality, and survival trends of esophageal, gastric, and pancreatic cancers in west midlands, england, from 1986 to 2000 in terms of socioeconomic deprivation.200516291386
seroprevalence of helicobacter pylori in patients with colorectal polyps and colorectal carcinoma.the role of helicobacter pylori in the pathogenesis of colorectal polyps and colorectal carcinoma is unknown. h. pylori infection causes fasting and meal stimulated hypergastrinemia. gastrin increases colorectal mucosal proliferation and promotes tumor growth. we performed a prospective study to determine the seroprevalence of h. pylori in patients with colorectal polyps and colorectal carcinoma and in controls.200111197293
modifying dyspepsia management in primary care: a cluster randomised controlled trial of educational outreach compared with passive guideline dissemination.quality improvement initiatives in health services rely upon the effective introduction of clinical practice guidelines. however, even well constructed guidelines have little effect unless supported by dissemination and implementation strategies.200312817353
molecular epidemiology of helicobacter pylori in england: prevalence of cag pathogenicity island markers and is605 presence in relation to patient age and severity of gastric disease.the caga gene is a key marker for the helicobacter pylori cag pathogenicity island (pai), which may vary in composition in different strains with insertion sequence mediated interruptions and deletions of genes. while presence of caga has been associated with increased risk for peptic ulcer disease and gastric cancer, the precise link with virulence is controversial. we investigated h. pylori from dyspeptics in one location in england (mid-essex) with reference to the prevalence and distribution ...200111172993
relationship between body mass and gastro-oesophageal reflux symptoms: the bristol helicobacter examine the relationship between body mass and gastro-oesophageal reflux in a large population-representative sample from the uk.200312913045
tracing clonality of helicobacter pylori infecting family members from analysis of dna sequences of three housekeeping genes (urei, atpa and ahpc), deduced amino acid sequences, and pathogenicity-associated markers (caga and vaca).helicobacter pylori, a gram-negative bacterium, is a causal agent of peptic ulcers and is estimated to infect the gastric mucosa of at least half of the world's population. as primary infections are acquired mainly by household contact, studies on family clusters provide a model for investigating transmission and the natural history of initial infection. here, sequence typing exploiting genetic variation in core fragments of three key housekeeping loci (urei, atpa and ahpc) was used to determine ...200312748272
helicobacter pylori test & treat strategy for dyspepsia: a qualitative study exploring the barriers and how to overcome them.the national institute of clinical excellence (nice) has issued guidance that recommends that all dyspeptic patients without alarm symptoms, irrespective of age, that relapse after one month's proton pump inhibitor, should be offered test and treat for helicobacter pylori.200616428262
what bizzozero never could imagine - helicobacter pylori today and tomorrow.with the observation of spiral organism in the stomach about one hundred years ago a long history of a bacterium started ending up in a worldwide research programs, studies and consensuses. with this bacterium rediscovered by marshall and warren and later named helicobacter pylori, a milestone of research was laid nearly twenty years ago. helicobacter pylori is now recognized as the main cause of most cases of gastritis and ulcer disease in the stomach and the duodenum. in the course of the heli ...200312829876
cost-effectiveness of population screening for helicobacter pylori in preventing gastric cancer and peptic ulcer disease, using evaluate the cost-effectiveness of population screening for helicobacter pylori in preventing gastric cancer and peptic ulcer disease in england and wales.200314561268
serological evidence of helicobacter pylori infection in uk south asian and european populations: implications for gastric cancer and coronary heart describe the prevalence of serological evidence of infection with helicobacter pylori among people of south asian and european ethnic origins and to assess its association with prevalent coronary heart disease (chd).200414720493
pro: endoscopy is necessary before treating helicobacter pylori in patients with dyspepsia. 200717335439
managing dyspepsia without alarm signs in primary care: new national guidance for england and report new recommendations for the primary care management of dyspepsia without alarm signs in england and wales.200515854176
tooth loss and helicobacter pylori seropositivity: the newcastle thousand families cohort study at age 49-51 years.helicobacter pylori, one of the commonest chronic bacterial infections of humankind, is an important risk factor for gastric carcinoma. it has also been suggested to be present in dental plaque. this study investigated the potential link between the number of teeth lost and h. pylori seropositivity at age 50 years.200515691320
helicobacter pylori eradication in long-term proton pump inhibitor users in primary care: a randomized controlled trial.two-thirds of proton pump inhibitor prescribing in the uk is for long-term therapy.200717305759
who consults with dyspepsia? results from a longitudinal 10-yr follow-up study.dyspepsia is common, and the condition is often chronic, with a relapsing and remitting nature. factors influencing the decision to consult a physician with symptoms remain unclear.200717313501
[historical development and current concepts on b-cell lymphomas of the marginal extraganglionar site of lymphoid tissue associated with malt lymphoma. a tribute to dennis h wright and peter g isaacson].significant advances in the understanding of marginal zone lymphoma since the first description in 1983 by peter isaacson and dennis wright have been noted. malt lymphomas are a subgroup of low-grade b-cell lymphomas that arise from extranodal sites, comprising 7-8% of all b-cell lymphomas and displaying distinct clinicopathological characteristics. malt lymphomas remain localized in the primary site for long periods of time and seldom disseminate unto other organs. these type of lymphomas infre ...200717722452
comparative genomics of helicobacter pylori isolates recovered from ulcer disease patients in england.genomic diversity of h. pylori from many different human populations is largely unknown. we compared genomes of 65 h. pylori strains from nottingham, england. molecular analysis was carried out to identify rearrangements within and outside the cag-pathogenicity-island (cag pai) and dna sequence divergence in candidate genes. phylogenetic analysis was carried out based on various high-resolution genotyping techniques.200515916705
surveillance of primary antibiotic resistance of helicobacter pylori at centres in england and wales over a six-year period (2000-2005).antibiotic resistance is a key factor in the failure of helicobacter pylori eradication therapy, yet few sentinel schemes exist to monitor trends in resistance at local, national or international levels. this study aimed, over a six-year period, to monitor resistance levels of h. pylori in england and wales to the four antibiotics used in its treatment. a total of 1,310 isolates from gwynedd in north wales and from mid-essex in south-east england were collected from 2000 to 2005 and tested for s ...200717991408
gastro-oesophageal reflux is more prevalent in western dyspeptics: a prospective comparison of british and south-east asian patients with dyspepsia.there is a paucity of data directly comparing dyspepsia in western and eastern populations.200515948816
real-time pcr detection and frequency of 16s rdna mutations associated with resistance and reduced susceptibility to tetracycline in helicobacter pylori from england and investigate the occurrence of 16s rdna mutations associated with resistance or reduced susceptibility to tetracycline in helicobacter pylori isolated in england and wales, and to develop a real-time pcr assay to detect these dna polymorphisms from culture and gastric biopsies.200515958499
effect of sibling number in the household and birth order on prevalence of helicobacter pylori: a cross-sectional study.infection with helicobacter pylori (h. pylori) is acquired mainly in childhood, with studies demonstrating this is related to living conditions. effects of sibling number and birth order on prevalence of infection have not been extensively studied.200717905807
irritable bowel syndrome: a 10-yr natural history of symptoms and factors that influence consultation behavior.irritable bowel syndrome (ibs) is a chronic functional gastrointestinal disorder. the natural history of the condition has been studied extensively, but few studies have examined factors that predict its new onset or health care-seeking behavior.200818371141
causes underlying the birth-cohort phenomenon of peptic ulcer: analysis of mortality data 1911-2000, england and wales.since humans have been infected with helicobacter pylori for millennia, it has remained an enigma why the occurrence of gastric and duodenal ulcer rose suddenly during 19th century. the study aim is to present a mathematical model of h. pylori epidemiology that explains the peculiar long-term trends of ulcer disease.200616709617
fluctuation of gastrointestinal symptoms in the community: a 10-year longitudinal follow-up study.there are few studies examining the stability of gastrointestinal symptoms during prolonged periods of follow-up.200818657131
rising trends of gastric cancer and peptic ulcer in the 19th century.the risk of dying from gastric cancer appears to have increased among consecutive generations born during the 19th century. aim: to follow the time trends of hospitalization for gastric cancer and test whether they confirm such increase.201020659282
initial poor quality of life and new onset of dyspepsia: results from a longitudinal 10-year follow-up study.numerous studies examining the prevalence and natural history of dyspepsia in the general population have been conducted. however, few have reported the effect of quality of life on the development of dyspepsia. a 10-year longitudinal follow-up study examining the effect of quality of life on subsequent dyspepsia was performed.200716908511
colonization of caga-positive helicobacter pylori is significantly greater in infected human males than females. a possible factor in distal gastric cancer gender difference. 200616758062
helicobacter pylori eradication in long-term proton pump inhibitor users is highly cost-effective: economic analysis of the helpup trial.proton pump inhibitor (ppi) use is costly and about two-thirds of prescribing is long-term. although 20-50% of patients may be infected with helicobacter pylori, eradication is not normal clinical practice.200818793340
why does japan have a high incidence of gastric cancer? comparison of gastritis between uk and japanese patients.the incidence of gastric cancer in japan is four times higher than in the uk. it usually arises in a stomach with corpus predominant or pangastritis that has undergone extensive atrophy and intestinal metaplasia. we hypothesised that a japanese population would have a more severe gastritis with a corpus predominant or pangastritis pattern and a greater degree of atrophy and intestinal metaplasia than that found in the uk. to test this we designed a comparative trial.200616603635
symptoms in patients on long-term proton pump inhibitors: prevalence and predictors.symptom control in primary care patients on long-term proton pump inhibitor (ppi) treatment is poorly understood.200919035981
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