differential helicobacter pylori infection rates in two contrasting gastric cancer risk regions of south china. china gastric cancer study group.carriers of helicobacter pylori are believed to have a three- to six-fold increased risk of developing gastric cancer. we have recently conducted a simultaneous cross-sectional population study on the prevalence of h. pylori infection in a cohort of asymptomatic adult volunteers in two contrasting gastric cancer risk regions of south china, hong kong and changle of fujian. their mean annual gastric cancer mortality has been approximately 7.5 and 75/100 000 population, respectively, since the beg ...199910029291
helicobacter pylori in meckel's diverticulum with heterotopic gastric mucosa in a population with relatively high h. pylori prevalence rate.helicobacter pylori (h. pylori) colonize only foveolar gastric-type mucosa and are associated with active chronic gastritis and peptic ulcer. the aim of this study was to investigate whether h. pylori can also be found in meckel's diverticulum which contains heterotopic gastric mucosa.199910207778
update on clarithromycin resistance in helicobacter pylori in hong kong and its effect on clarithromycin-based triple determine the antibiotic susceptibility of helicobacter pylori and evaluate the efficacy of a clarithromycin-based triple therapy in relation to antibiotic resistance.200616788304
how effective are quadruple therapies as first-line h. pylori eradication therapies? 200516265179
trends in the prevalence of peptic ulcer disease and helicobacter pylori infection in family physician-referred uninvestigated dyspeptic patients in hong kong.peptic ulcer disease is mainly caused by helicobacter pylori infection and the use of non-steroidal anti-inflammatory drugs.200516091062
levofloxacin-resistant helicobacter pylori in hong kong.fluoroquinolone-resistant helicobacter pylori emerged in 1995 and the resistance was due to point mutation in the gyra gene. in this study we investigate the resistance mechanism and the antimicrobial susceptibilities of clarithromycin, metronidazole, amoxicillin, tetracycline and telithromycin against levofloxacin-resistant h. pylori in hong kong.200818073471
evaluation of anti-helicobacter pylori igg2 antibody for the diagnosis of helicobacter pylori infection in western and chinese populations.the performance of commercial helicobacter pylori diagnostic kits developed for particular geographic regions has often been found to be of poor diagnostic value when applied to other regions, possibly because of infections being caused by different h. pylori strains in different regions.200515644049
duodenal ulcers dominate acute upper gastrointestinal tract bleeding in childhood: a 10-year experience from hong kong.systematic reports on acute upper gastrointestinal bleeding in children/adolescents are scanty. the aim of this study is to analyze its presentation, pathology and outcome in hong kong.200818959590
the antimicrobial susceptibility of helicobacter pylori in hong kong (1997-2001). 200212390214
specialized intestinal metaplasia and carditis at the gastroesophageal junction in chinese patients undergoing endoscopy.specialized intestinal metaplasia (sim) is often found at a normal-looking gastroesophageal junction on routine biopsy. the prevalence of sim in asian populations has not been recorded. its significance is also unclear. the objective of the study was to document the prevalence of sim at the gastroesophageal junction in a chinese population undergoing endoscopy.200212190155
distribution of distinct vaca, caga and icea alleles in helicobacter pylori in hong kong.there is a substantial genetic heterogeneity among helicobacter pylori strains, and certain genotypes have been suggested to be associated with the virulence of this pathogen. the aim of this study was to investigate the distribution of h. pylori vaca, caga and icea genotypes and their association with duodenal ulcer disease in hong kong.200111843964
clinical and endoscopic characteristics of non-helicobacter pylori, non-nsaid duodenal ulcers: a long-term prospective study.the proportion of duodenal ulcers not associated with helicobacter pylori infection or the use of non-steroidal anti-inflammatory drugs (nsaids) is increasing.200111736717
helicobacter pylori infection in chinese subjects with type 2 diabetes.the relationship between diabetes and helicobacter pylori (hp) infection is controversial. in this study, we examined the possible relationship between hp infection and type 2 diabetes in chinese subjects. sixty-three chinese type 2 diabetic patients (mean age +/- sd: 49.9 +/- 12.0 years; range: 17-76 years) were recruited irrespective of the duration of diabetes or type of therapy. twenty-nine (46%) of them had upper gastrointestinal symptoms and the other 34 (54%) did not. another 55 age- and ...200111428708
economic analysis of four triple regimens for the treatment of helicobacter pylori-related peptic ulcer disease in in-patient and out-patient settings in hong triple regimens have been shown to be effective for the treatment of helicobacter pylori-related peptic ulcer disease.200111421876
high prevalence of mixed infections by helicobacter pylori in hong kong: metronidazole sensitivity and overall genotype.diversity in metronidazole susceptibility and genotypes of helicobacter pylori have been reported with varying results in different areas.200111284778
one-week ranitidine bismuth citrate-based triple therapy for the eradication of helicobacter pylori in hong kong with high prevalence of metronidazole compare 1-week ranitidine bismuth citrate-based (rbc) triple therapy vs. omeprazole-based (o) triple therapy for the eradication of helicobacter pylori infection in hong kong with high prevalence of metronidazole resistance.200111207516
high prevalence of helicobacter pylori infection with dual resistance to metronidazole and clarithromycin in hong kong.metronidazole resistance is a common problem in most asian countries, and clarithromycin has been widely used in hong kong.200010886046
prevalence and distribution of helicobacter pylori in gastroesophageal reflux disease: a study from the east.the relationship between helicobacter pylori infection and gastroesophageal reflux (h. pylori) disease (gerd) is controversial. in asian populations, the prevalence of h. pylori infection is high and gerd is relatively uncommon. the aim of this study was 1) to test the hypothesis that h. pylori protects the esophagus against gerd, and 2) to study the pattern of h. pylori colonization and gastritis in gerd.199910406236
antiulcer drug prescribing in hospital successfully influenced by "immediate concurrent feedback".to determine whether immediate concurrent feedback (icf) focused on inpatient omeprazole prescribing achieved more rational and cost-effective antiulcer drug prescribing and usage.19989834050
helicobacter pylori in an institution for disabled children in hong kong.anti-helicobacter pylori antibodies were determined in 157 institutionalised cantonese children, mean age 9.5 +/- 3.9 (sd) years, with profound neurodevelopmental disabilities. eighty-seven (55.4%) were h. pylori seropositive compared with four of 50 (8%, p > 0.0002) of an age-matched control group, mean age 7.2 +/- 4.3 (sd) years. eight of 15 seropositive children with a recent history of upper gastrointestinal bleeding underwent endoscopy and in all cases gastric infection with h.pylori was co ...19979352730
pathogenesis of gastric lymphoma: the enigma in hong kong.helicobacter pylori (h. pylori) infection has been postulated to be a pathogenetic factor in gastric lymphoma. however, the etiological factors for gastric lymphoma could vary in different populations.19979209639
prevalence of metronidazole resistant helicobacter pylori strains among chinese peptic ulcer disease patients and normal controls in hong kong.a study was conducted to evaluate the prevalence of metronidazole resistant helicobacter pylori strains among the chinese in hong kong. the efficacy of the triple therapy that contains metronidazole as one of the anti-microbial agents in eradication of the metronidazole susceptible and the metronidazole resistant strains was also assessed.19968707111
lansoprazole, levofloxacin and amoxicillin triple therapy vs. quadruple therapy as second-line treatment of resistant helicobacter pylori test the efficacy of levofloxacin-based second-line therapy for resistant helicobacter pylori infection.200616423001
seroprevalence of helicobacter pylori in chinese patients on continuous ambulatory peritoneal dialysis.there is relatively little data on the seroprevalence of helicobacter pylori in patients undergoing continuous ambulatory peritoneal dialysis (capd). this study aims at establishing the seroprevalence of and the factors associated with h. pylori infection in chinese capd patients.200515705177
long-term prospective follow-up of endoscopic oesophagitis in southern chinese--prevalence and spectrum of the study the prevalence, clinical characteristics and long-term outcome of oesophagitis in chinese patients.200212452935
triple therapy with clarithromycin, omeprazole, and amoxicillin for eradication of helicobacter pylori in duodenal ulcer patients in asia and africa.studies assessing the efficacy of triple therapy containing clarithromycin and amoxicillin for the eradication of helicobacter pylori infection and healing of duodenal ulcers in asian and african countries are limited.200011069326
seroprevalence of cytotoxin-associated gene a positive helicobacter pylori strains in changle, an area with very high prevalence of gastric cancer in south china.helicobacter pylori, especially the caga-positive strains, are closely associated with peptic ulcers and gastric cancers. we performed a large scale gastric cancer screening project and examined the prevalence of h. pylori and caga-positive strains in changle, china, an area with one of the world's highest gastric cancer mortality. we also compared the prevalence with that in hong kong which has one-tenth of the gastric cancer mortality of that in changle.199910540043
helicobacter pylori heat shock protein a: serologic responses and genetic diversity.helicobacter pylori synthesizes an unusual groes homolog, heat shock protein a (hspa). the present study was aimed at an assessment of the serological response to hspa in a group of chinese patients with defined gastroduodenal pathologies and determination of whether diversity is present in the nucleotide sequences encoding hspa in isolates from these patients. serum samples collected from 154 patients who had an upper gastrointestinal pathology and the presence of h. pylori defined by biopsy we ...199910225839
4th seah cheng siang memorial lecture. primary gastrointestinal lymphoma in hong kong.many primary gastrointestinal lymphomas (pgl) are treatable and carry a good prognosis, particularly of localized and of "low grade" malignancy. in general, the stomach is the most commonly involved site followed by the small and then large intestines. the incidence of gastric lymphoma may be on the rise, and the response of lymphoma arising from gastric mucosa associated lymphoid tissue (malt) to treatment of the co-existing helicobacter pylori infection has added a new dimension to the study o ...19947944264
non-invasive serological detection of helicobacter pylori antigens in adult hong kong chinese non-ulcer dyspepsia patients.the aim of our study was to evaluate the accuracy of the serology test kit (signify h. pylori test), an office-based serological test and to compare relative performances with endoscopy, including biopsy urease tests (clotest), histology, and culture when applied to dyspeptic adult patients in hong kong chinese.200717372779
noncardiac chest pain--an asia-pacific survey on the views of primary care physicians.noncardiac chest pain (nccp) is common and has a significant impact on health care. primary care physicians (pcps)' attitudes, clinical approach, preference of diagnostic tests, referral patterns, and comfort in managing patients with nccp in the asia-pacific region are not known. consequently, we performed this survey in the asia-pacific region. the self-completed questionnaire was sent to pcps in the asia-pacific region. a 28-item questionnaire contained questions on demographic information, c ...200717436083
a population-based study of helicobacter pylori infection in chinese children resident in hong kong: prevalence and potential risk of helicobacter pylori prevalence in children and its risk factors provide clues to the health authority to estimate burden of h. pylori-associated diseases usually encountered in adulthood and facilitate healthcare planning.200818466397
prevalence and time trend of intestinal metaplasia in hong kong.upper endoscopy records from 1998 to 2003 were reviewed. the demographic data, endoscopic diagnosis, results of rapid urease test and the absence or presence of intestinal metaplasia (im) in histology were reviewed, to evaluate the prevalence of im and helicobacter pylori (hp) infection over time in hong kong.200919646018
clarithromycin-amoxycillin-containing triple therapy: a valid empirical first-line treatment for helicobacter pylori eradication in hong kong?recent studies have suggested the eradication rate for helicobacter pylori infection with standard amoxycillin-clarithromycin-containing triple therapy as first-line treatment have fallen below 80%. levofloxacin-containing triple therapy was proposed as an alternative. the aim of this study is to compare the efficacy and tolerability of the standard 7-day clarithromycin-containing triple therapy against the 7-day levofloxacin-containing triple therapy, and to assess whether the classical triple ...200919889067
pharmacogenetics of esomeprazole or rabeprazole-based triple therapy in helicobacter pylori eradication in hong kong non-ulcer dyspepsia chinese subjects.our study aimed to assess the effectiveness of esomeprazole or rabeprazole in combination with amoxicillin and clarithromycin for the eradication of helicobacter pylori in hong kong non-ulcer dyspepsia (nud) patients.201020831535
sequencing analysis of the 3' region of the caga gene in helicobacter pylori isolated from hong kong chinese patients. 201020864739
nonbismuth concomitant quadruple therapy for helicobacter pylori eradication in chinese regions: a meta-analysis of randomized controlled evaluate the applicability of nonbismuth concomitant quadruple therapy for helicobacter pylori (h. pylori) eradication in chinese regions.201627340362
gastroduodenal involvement in asymptomatic crohn's disease patients in two areas of emerging disease: asia and eastern europe.the incidence of crohn's disease [cd] is increasing in asia and eastern europe. limited studies have reported on the frequency of upper gastrointestinal [gi] involvement in patients with cd in non-western countries. this prospective study compared the rate of macroscopic and microscopic upper gi manifestations and helicobacter pylori positivity in asymptomatic cd patients in asia and eastern europe.201627282400
association between acute neuropsychiatric events and helicobacter pylori therapy containing clarithromycin.there is a concern that helicobacter pylori therapy containing clarithromycin might be associated with acute neuropsychiatric events.201627136661
cardiovascular outcomes associated with use of clarithromycin: population based study.what is the association between clarithromycin use and cardiovascular outcomes?201626768836
managing peptic ulcer and gastroesophageal reflux disease in elderly chinese patients--focus on esomeprazole.peptic ulcer disease (pud) and gastroesophageal reflux disease (gerd) are not uncommon in elderly patients. clinical presentations of these acid-related disorders may be atypical in the geriatric population. older individuals are at increased risk for poor outcomes in complicated pud and for development of gerd complications. multiple risk factors (eg, helicobacter pylori [hp], use of nonsteroidal anti-inflammatory drugs [nsaids], aspirin) contribute to the development of pud. recent data has sh ...201324187492
treatment of functional dyspepsia with sertraline: a double-blind randomized placebo-controlled pilot evaluate sertraline, a selective serotonin reuptake inhibitor in the treatment of patients with functional dyspepsia.201223155342
low plasma adiponectin level, white blood cell count and helicobacter pylori titre independently predict abnormal pancreatic beta-cell function.adiponectin is an adipocytokine with insulin sensitizing effect while chronic inflammation damages pancreatic beta-cells leading to reduced insulin response. we aimed to prove the hypothesis that adiponectin levels and inflammatory markers (white blood cell counts [wcc], helicobacter pylori [hp] titers, high sensitivity c-reactive protein [hs-crp]) may interact to affect risk of diabetes. we studied 288 chinese men (age-median: 41.0 years, iqr: 35.3-46.0 years) being recruited from the community ...200919747747
cost-effectiveness of helicobacter pylori screening and treatment for gastric cancer in hong kong: a decision analytic approach. 201425647818
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