Publications

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epidemiology of helicobacter pylori in southern china: identification of early childhood as the critical period for acquisition.a large cross-sectional study to investigate the prevalence and possible modes of transmission of helicobacter pylori was done in southern china. serum samples (1727) were collected from guangzhou city and three rural areas of guangdong province, and the prevalence of h. pylori infection was determined using an elisa. each subject completed a questionnaire. the overall prevalence of h. pylori infection was 44.2%; a significantly higher prevalence was found in guangzhou (52.4%) than in the rural ...19921607687
[association of single nucleotide polymorphism at interleukin-10 gene 1082 nt with the risk of gastric cancer in chinese population].to study the association of single nucleotide polymorphism at interleukin-10 gene 1082 locus with helicobacter pylori (hp) infection and the risk of gastric cancer in high prevalent region (shaanxi province)aand low prevalence region (guangdong province) in china.200818753053
decreasing seroprevalence of helicobacter pylori infection during 1993-2003 in guangzhou, southern china.prevalence of helicobacter pylori infection is inversely associated with socioeconomic conditions. the aim of the study was to evaluate changes in the seroprevalence of h. pylori infection during 1993-2003 in guangzhou, a representative city of southern china with quick improvement in socioeconomy.200717309754
[genotypic study on the helicobacter pylori vaca, caga and icea genes in the infected children in guangzhou area].to investigative vaca, caga and icea genes dominant genotypes of helicobacter pylori (hp) isolated from children suffering from gastric and duodenal diseases in guangzhou area.200718021567
core genome haplotype diversity and vaca allelic heterogeneity of chinese helicobacter pylori strains.the human gastric pathogen, helicobacter pylori, has co-evolved with its host and established itself in the human stomach possibly millions of years ago. therefore, the diversity of this bacterium is important in its clinical manifestations. our aim has been to evaluate the genetic diversity of 40 h. pylori clinical isolates from four different parts of china. the methods of multi-locus sequence typing and vaca allele genotyping were used to assess their genetic diversity. to discriminate mlst, ...200919452214
assessment of clarithromycin-resistant helicobacter pylori among patients in shanghai and guangzhou, china, by primer-mismatch pcr.of 96 helicobacter pylori isolates from patients in shanghai and guangzhou, china, 5 had the a2143g 23s rrna mutation as determined by primer-mismatch pcr and were resistant to clarithromycin by the e-test. the remaining isolates were primer-mismatch pcr negative and susceptible to clarithromycin. the conclusion is that the prevalence of clarithromycin-resistant h. pylori isolates among these chinese patients is 5%.200211773126
gastric atrophy and regional variation in upper gastrointestinal disease.to compare the upper gastrointestinal disease profiles of helicobacter pylori-infected patients drawn from two distinct regions of china, one with a low incidence of gastric cancer (guangzhou) and the other with a high incidence of gastric cancer (lanzhou). the age-standardized prevalence of h. pylori within the populations of these two cities was similar (approximately 56%). in these patient groups, the prevalence of different gastrointestinal disease states and the occurrence and severity of g ...19957611205
study on the relationship between helicobacter pylori in the dental plaque and the occurrence of dental caries or oral hygiene index.the aims of our study were to determine the presence of helicobacter pylori dna in the dental plaque of chinese children aged 3-6 years by nested polymerase chain reaction (pcr) and to investigate the relationship between this infection and the occurrence of dental caries or oral hygiene index.200818665933
association of interleukin 1b gene polymorphism and gastric cancers in high and low prevalence regions in china.our aim was to study the relationship between interleukin 1b (il-1b) polymorphism, helicobacter pylori infection, and gastric cancer in high prevalent (shanxi) and low prevalent (guangdong) regions in china.200314633943
il23r +2199a/c polymorphism is associated with decreased risk of certain subtypes of gastric cancer in chinese: a case-control study.today, the causal relationship between inflammation and gastric cancer is more widely accepted. genetic variations in inflammation-related genes especially cytokines and their receptors, were thought to partly determine the outcome of helicobacter pylori (h. pylori) infection and progression of gastric lesions. interleukin 23 receptor (il23r), as a key cytokine receptor gene in the important inflammatory il-17/il-23 axis, may contribute to gastric cancer predisposition. up till now, the associat ...201020863779
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